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One or more keywords matched the following properties of Bissonnette, Bruce
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overview Brief Summary of Clinical activities: General gastroenterology. Diagnosis, management, and where appropriate, triage of patients with gastrointestinal disorders, including abdominal pain, GI bleeding, iron deficiency anemia, diarrhea, constipation, malabsorption, weight loss, GERD (esophageal reflux), swallowing difficulties, esophageal strictures, peptic ulcer disease, Barrett’s esophagus, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colon polyps and colon cancer, diverticulitis, gastritis, H pylori infections, angioectasias (AVMs), radiation proctitis, pancreatitis and liver abnormalities. Brief Summary of Research activities: 1. Colon cancer pathogenesis and chemoprevention – Our laboratory is focused on the role of diet and signaling pathways that promote or inhibit colon cancer development. These include tumor-promoting Western diets, and inhibitory fish oil diets, growth factor signals and cytokine signals, focusing on ADAM17-EGFR and CXCL12-CXCR4. For these studies, we use animal models, primary human tissue and colonic organoids, and in vitro cell culture models. We are currently carrying out a broad screen of natural products for compounds that inhibit CXCL12-CXCR4 interaction as potential chemopreventive agents for colon cancer. 2. Development of a liquid biopsy (blood test) for colon cancer screening. In collaboration with Dr. Chuan He at the University of Chicago and Dr. Wei Zhang at Northwestern University, we are developing biomarker assays in the blood using 5-hydroxymethylcytosine to diagnose patients with advanced adenomas and early CRC. Similar assays will be used to prognosticate the likelihood of tumor recurrence and assess responses to anti-tumor therapies. 3. Elucidation of the role of Ythdf1 in colon cancer development. Ythdf1 binds N6-methyadenosine (m6A) in mRNA to increase mRNA translation We showed that deletion of Ythdf1 in dendritic cells activated the antigen-specific CD8+ T cell anti-tumor response allowing recognition and killing of colon cancer cells. We are currently studying conditional (LoxP) compound mutant mice with LoxP Ythdf1 and LoxP Apc genes to uncover the role of this m6A mRNA reader in early colonic carcinogenesis. 4. Dissection of the role of the pro-renin receptor (Atp6ap2) in colon cancer. In prior studies we showed that inhibition of the renin-angiotensin system (RAS) is essential for the chemopreventive efficacy of vitamin D to suppress colon tumor development. Vitamin D suppresses renin transcription to reduce RAS signals. AT1 receptor blockade by losartan also suppresses tumor development. The (pro)renin receptor binds renin and catalyzes renin protease activity and induces Wnt signaling. In collaboration with Dr. Yan Chun Li, we are investigating colonic tumorigenesis in mice with conditional deletion of (pro)renin receptor. This deletion (and wild type controls) will be combined with mice expressing a transgene driving renin over-expression.
One or more keywords matched the following items that are connected to Bissonnette, Bruce
Item TypeName
Concept Surveys and Questionnaires
Concept Retrospective Studies
Concept Signal Transduction
Academic Article Characterization of phosphoinositide-specific phospholipase C in rat colonocyte membranes.
Academic Article Modulation of P-glycoprotein-mediated drug transport by alterations in lipid fluidity of rat liver canalicular membrane vesicles.
Academic Article Ursodeoxycholic acid and F(6)-D(3) inhibit aberrant crypt proliferation in the rat azoxymethane model of colon cancer: roles of cyclin D1 and E-cadherin.
Academic Article Polyethylene glycol inhibits intestinal neoplasia and induces epithelial apoptosis in Apc(min) mice.
Academic Article Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer.
Academic Article Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier.
Academic Article Clinical use of p53 in Barrett's esophagus.
Academic Article Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis.
Academic Article Polyethylene glycol-mediated colorectal cancer chemoprevention: roles of epidermal growth factor receptor and Snail.
Academic Article Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis.
Academic Article Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer.
Academic Article Epidermal growth factor receptor is required for colonic tumor promotion by dietary fat in the azoxymethane/dextran sulfate sodium model: roles of transforming growth factor-{alpha} and PTGS2.
Academic Article Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci.
Academic Article The microbe-derived short chain fatty acid butyrate targets miRNA-dependent p21 gene expression in human colon cancer.
Academic Article Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer.
Academic Article Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts.
Academic Article Ultra-performance liquid chromatography and time-of-flight mass spectrometry analysis of ginsenoside metabolites in human plasma.
Academic Article Inactivation of the vitamin D receptor in APC(min/+) mice reveals a critical role for the vitamin D receptor in intestinal tumor growth.
Academic Article Ursodeoxycholic acid suppresses Cox-2 expression in colon cancer: roles of Ras, p38, and CCAAT/enhancer-binding protein.
Academic Article miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes.
Academic Article 1,25-Dihydroxyvitamin D3 stimulates the phosphorylation of two acidic membrane proteins of 42,000 and 48,000 daltons in rat colonocytes: an effect modulated by vitamin D status.
Academic Article American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR.
Academic Article EGFR signals downregulate tumor suppressors miR-143 and miR-145 in Western diet-promoted murine colon cancer: role of G1 regulators.
Academic Article AMP-18 facilitates assembly and stabilization of tight junctions to protect the colonic mucosal barrier.
Academic Article Chitinase 3-like-1 expression in colonic epithelial cells as a potentially novel marker for colitis-associated neoplasia.
Academic Article Estrogen receptor-ß protects against colitis-associated neoplasia in mice.
Academic Article 1,25(OH)2 vitamin D3 activates PKC-alpha in Caco-2 cells: a mechanism to limit secosteroid-induced rise in [Ca2+]i.
Academic Article Cholesterol modulates alkaline phosphatase activity of rat intestinal microvillus membranes.
Academic Article A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model.
Academic Article Epidermal growth factor receptor controls flat dysplastic aberrant crypt foci development and colon cancer progression in the rat azoxymethane model.
Academic Article Selective preservation of protein kinase C-zeta in the chemoprevention of azoxymethane-induced colonic tumors by piroxicam.
Academic Article Vitamin D status modulates rat colonic M3 muscarinic receptor characteristics and coupling to guanylate cyclase.
Academic Article Upregulation of glycogen synthase kinase 3ß in human colorectal adenocarcinomas correlates with accumulation of CTNNB1.
Academic Article 1,25 dihydroxyvitamin D3 stimulates phospholipase C-gamma in rat colonocytes: role of c-Src in PLC-gamma activation.
Academic Article 1,25-Dihydroxyvitamin D3 and 12-O-tetradecanoyl phorbol 13-acetate cause differential activation of Ca(2+)-dependent and Ca(2+)-independent isoforms of protein kinase C in rat colonocytes.
Academic Article Chemoprevention of colon carcinogenesis by polyethylene glycol: suppression of epithelial proliferation via modulation of SNAIL/beta-catenin signaling.
Academic Article Sorafenib inhibits MAPK-mediated proliferation in a Barrett's esophageal adenocarcinoma cell line.
Academic Article Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions.
Academic Article Evaluation of microvascular density in Barrett's associated neoplasia.
Academic Article Gene signature distinguishes patients with chronic ulcerative colitis harboring remote neoplastic lesions.
Academic Article The renin-angiotensin system mediates EGF receptor-vitamin d receptor cross-talk in colitis-associated colon cancer.
Academic Article Sorafenib triggers antiproliferative and pro-apoptotic signals in human esophageal adenocarcinoma cells.
Academic Article Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators.
Academic Article Transforming growth factor-beta 1 signaling contributes to Caco-2 cell growth inhibition induced by 1,25(OH)(2)D(3).
Academic Article Rapid effects of 1,25(OH)2 vitamin D3 on signal transduction systems in colonic cells.
Academic Article 1,25-Dihydroxyvitamin D3 targets PKC-betaII but not PKC-alpha to the basolateral plasma membranes of rat colonocytes.
Academic Article Protein kinase C and mitogen-activated protein kinase are required for 1,25-dihydroxyvitamin D3-stimulated Egr induction.
Academic Article Protein kinase C mediates the calcium-induced activation of rat colonic particulate guanylate cyclase.
Academic Article Titanium dioxide in the service of the biomedical revolution.
Academic Article Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis.
Academic Article Lithocholic acid down-regulation of NF-kappaB activity through vitamin D receptor in colonic cancer cells.
Academic Article Protein Kinase-zeta inhibits collagen I-dependent and anchorage-independent growth and enhances apoptosis of human Caco-2 cells.
Academic Article Adolescents' perspectives and food choice behaviors in terms of the environmental impacts of food production practices: application of a psychosocial model.
Academic Article A vitamin D3 analog induces a G1-phase arrest in CaCo-2 cells by inhibiting cdk2 and cdk6: roles of cyclin E, p21Waf1, and p27Kip1.
Academic Article 1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent Caco-2 cell differentiation.
Academic Article TPA causes divergent responses of Ca(2+)-dependent and Ca(2+)-independent isoforms of PKC in the nuclei of Caco-2 cells.
Academic Article Arterial anatomy of the thumb.
Academic Article Renal permeability alteration precedes hypertension and involves bradykinin in the spontaneously hypertensive rat.
Academic Article A new dynamic splint for postoperative treatment of flexor tendon injury.
Academic Article Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway.
Academic Article TU-100 (Daikenchuto) and ginger ameliorate anti-CD3 antibody induced T cell-mediated murine enteritis: microbe-independent effects involving Akt and NF-?B suppression.
Academic Article Is RXRa crucially involved in intestinal inflammation?
Academic Article Sprouty-2 controls c-Met expression and metastatic potential of colon cancer cells: sprouty/c-Met upregulation in human colonic adenocarcinomas.
Academic Article Functional analysis of the transmembrane domain in paramyxovirus F protein-mediated membrane fusion.
Academic Article Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1.
Academic Article Guanylin activates rat colonic particulate guanylate cyclase.
Academic Article Analysis of the pH requirement for membrane fusion of different isolates of the paramyxovirus parainfluenza virus 5.
Academic Article 1,25-dihydroxyvitamin D3 but not TPA activates PLD in Caco-2 cells via pp60(c-src) and RhoA.
Academic Article Expression of G protein alpha subunits in normal rat colon and in azoxymethane-induced colonic neoplasms.
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