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overview Dr. Dulin’s laboratory investigates the signaling mechanisms of TGF-beta-induced myofibroblast differentiation as related to pathogenesis of pulmonary fibrosis, using cell culture and animal models of the disease. His studies have described the critical role for serum response factor (SRF) in myofibroblast differentiation and pulmonary fibrosis, as well as the control of this pathway by actin and microtubule dynamics. The other direction of Dr. Dulin research relates to the basic studies on the biological function of the regulators of G protein signaling (RGS) proteins, focusing on RGS3 member of the family. His group has shown that RGS3 regulates the signaling mediated by heterotrimeric Gi and Gq proteins, as well as non-canonically of TGF-beta signaling. Together with Dr. Anne Sperling, they established the role of RGS3 in control of T cell migration and T cell – mediated inflammation, using knock-down and knockout approaches. His current studies focus on the function of endogenous RGS3 as related to cancer cell growth, migration and EMT. Dr. Dulin's NIH Commons ID is NDULIN
One or more keywords matched the following items that are connected to Dulin, Nickolai
Item TypeName
Concept Idiopathic Pulmonary Fibrosis
Concept Pulmonary Fibrosis
Academic Article Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-ß.
Academic Article Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin.
Academic Article Antifibrotic effects of noscapine through activation of prostaglandin E2 receptors and protein kinase A.
Academic Article Megakaryoblastic leukemia-1 is required for the development of bleomycin-induced pulmonary fibrosis.
Academic Article Regulation of myofibroblast differentiation by cardiac glycosides.
Academic Article SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.
Academic Article Transforming Growth Factor (TGF)-ß Promotes de Novo Serine Synthesis for Collagen Production.
Academic Article Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.
Academic Article P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-ß1, -ß2, and -ß3 Translation.
Academic Article Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation.
Academic Article Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling.
Grant Fibroblast Biology and Pulmonary Fibrosis
Grant Control of myofibroblast activation and pulmonary fibrosis by Na/K-ATPase
Academic Article Anoctamin-1 is induced by TGF-ß and contributes to lung myofibroblast differentiation.
Search Criteria
  • Pulmonary Fibrosis