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Search Results to Carole Ober

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overview The research goals of my laboratory are to identify genetic variants that influence gene expression and epigenetic marks in tissues relevant to complex phenotypes and common diseases, in particular those related to asthma, allergy and preterm birth. To this end we are using both freshly isolated cells and tissues and cell culture models of gene-environment interactions to dissect the genetic architecture of common diseases. Our studies are conducted in founder populations, the Hutterites of South Dakota and the Amish of northern Indiana, in U.S. and European birth cohorts, and in patient populations from Chicago.

One or more keywords matched the following items that are connected to Ober, Carole

Item TypeName
Concept Asthma
Academic Article A second-generation genomewide screen for asthma-susceptibility alleles in a founder population.
Academic Article Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus.
Academic Article Sequence variation in the promoter region of the cholinergic receptor muscarinic 3 gene and asthma and atopy.
Academic Article Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy.
Academic Article Sex-specific genetic architecture of human disease.
Academic Article Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility.
Academic Article Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci.
Academic Article Gene-environment interactions in human disease: nuisance or opportunity?
Academic Article Allele-specific targeting of microRNAs to HLA-G and risk of asthma.
Academic Article Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life.
Academic Article The genetics of asthma and allergic disease: a 21st century perspective.
Academic Article IFNG genotype and sex interact to influence the risk of childhood asthma.
Academic Article Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
Academic Article Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects.
Academic Article Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases.
Academic Article The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.
Academic Article Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy.
Academic Article Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population.
Academic Article Rising prevalence of asthma is sex-specific in a US farming population.
Academic Article Resequencing candidate genes implicates rare variants in asthma susceptibility.
Academic Article Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
Academic Article Association studies for asthma and atopic diseases: a comprehensive review of the literature.
Academic Article Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.
Academic Article Gene-environment interaction effects on the development of immune responses in the 1st year of life.
Academic Article Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.
Academic Article Rethinking genetic models of asthma: the role of environmental modifiers.
Academic Article Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans.
Academic Article Maternal microchimerism protects against the development of asthma.
Academic Article Rhinovirus wheezing illness and genetic risk of childhood-onset asthma.
Academic Article A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
Academic Article Maternal asthma and microRNA regulation of soluble HLA-G in the airway.
Academic Article Genome-wide interaction studies reveal sex-specific asthma risk alleles.
Academic Article Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma.
Academic Article Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma.
Academic Article Genome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways.
Academic Article Leveraging gene-environment interactions and endotypes for asthma gene discovery.
Academic Article Asthma Genetics in the Post-GWAS Era.
Academic Article Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.
Academic Article DNA methylation in lung cells is associated with asthma endotypes and genetic risk.
Award or Honor Receipt John E. Salvaggio Memorial Lectureship
Award or Honor Receipt Charles Reed Lectureship
Grant Prenatal Origins of Asthma
Grant Mendelian Disease - Asthma Comorbidity to Find Subgroup-Specific Asthma Genes
Grant Rhinovirus Infections and Asthma in Children and Adolescents
Academic Article A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle.
Academic Article Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Academic Article Immune development and environment: lessons from Amish and Hutterite children.
Academic Article Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
Academic Article Associations between fungal and bacterial microbiota of airways and asthma endotypes.
Academic Article Advances in asthma and allergic disease genetics: Is bigger always better?

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