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overview The research goals of my laboratory are to identify genetic variants that influence gene expression and epigenetic marks in tissues relevant to complex phenotypes and common diseases, in particular those related to asthma, allergy and preterm birth. To this end we are using both freshly isolated cells and tissues and cell culture models of gene-environment interactions to dissect the genetic architecture of common diseases. Our studies are conducted in founder populations, the Hutterites of South Dakota and the Amish of northern Indiana, in U.S. and European birth cohorts, and in patient populations from Chicago.
One or more keywords matched the following items that are connected to Ober, Carole
Item TypeName
Concept Asthma
Concept Severity of Illness Index
Academic Article A second-generation genomewide screen for asthma-susceptibility alleles in a founder population.
Academic Article Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus.
Academic Article Sequence variation in the promoter region of the cholinergic receptor muscarinic 3 gene and asthma and atopy.
Academic Article Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy.
Academic Article Sex-specific genetic architecture of human disease.
Academic Article Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility.
Academic Article Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci.
Academic Article Gene-environment interactions in human disease: nuisance or opportunity?
Academic Article Allele-specific targeting of microRNAs to HLA-G and risk of asthma.
Academic Article Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life.
Academic Article The genetics of asthma and allergic disease: a 21st century perspective.
Academic Article IFNG genotype and sex interact to influence the risk of childhood asthma.
Academic Article Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
Academic Article Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects.
Academic Article Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases.
Academic Article The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.
Academic Article Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy.
Academic Article Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population.
Academic Article Rising prevalence of asthma is sex-specific in a US farming population.
Academic Article Resequencing candidate genes implicates rare variants in asthma susceptibility.
Academic Article Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
Academic Article Association studies for asthma and atopic diseases: a comprehensive review of the literature.
Academic Article Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.
Academic Article Gene-environment interaction effects on the development of immune responses in the 1st year of life.
Academic Article Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.
Academic Article Rethinking genetic models of asthma: the role of environmental modifiers.
Academic Article Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans.
Academic Article Maternal microchimerism protects against the development of asthma.
Academic Article Rhinovirus wheezing illness and genetic risk of childhood-onset asthma.
Academic Article The maternal HLA-G 1597?C null mutation is associated with increased risk of pre-eclampsia and reduced HLA-G expression during pregnancy in African-American women.
Academic Article A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
Academic Article Maternal asthma and microRNA regulation of soluble HLA-G in the airway.
Academic Article Genome-wide interaction studies reveal sex-specific asthma risk alleles.
Academic Article Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma.
Academic Article Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma.
Academic Article Genome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways.
Academic Article Leveraging gene-environment interactions and endotypes for asthma gene discovery.
Academic Article Asthma Genetics in the Post-GWAS Era.
Academic Article Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.
Academic Article DNA methylation in lung cells is associated with asthma endotypes and genetic risk.
Award or Honor Receipt John E. Salvaggio Memorial Lectureship
Award or Honor Receipt Charles Reed Lectureship
Grant Prenatal Origins of Asthma
Grant Mendelian Disease - Asthma Comorbidity to Find Subgroup-Specific Asthma Genes
Grant Rhinovirus Infections and Asthma in Children and Adolescents
Academic Article A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle.
Academic Article Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Academic Article Immune development and environment: lessons from Amish and Hutterite children.
Academic Article Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
Academic Article Associations between fungal and bacterial microbiota of airways and asthma endotypes.
Academic Article Author Correction: Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.
Academic Article Advances in asthma and allergic disease genetics: Is bigger always better?
Academic Article Association of HLA-DRB1*09:01 with tIgE levels among African-ancestry individuals with asthma.
Academic Article Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation.
Academic Article Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2.
Academic Article Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study.
Academic Article Epigenome-wide association study of DNA methylation and adult asthma in the Agricultural Lung Health Study.
Academic Article Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma.
Academic Article Altered transcriptional and chromatin responses to rhinovirus in bronchial epithelial cells from adults with asthma.
Academic Article FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses.
Academic Article A-to-I editing of miR-200b-3p in airway cells is associated with moderate-to-severe asthma.
Academic Article Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood.
Academic Article Genome-wide association study identifies TNFSF15 associated with childhood asthma.
Academic Article Multiethnic genome-wide and HLA association study of total serum IgE level.
Academic Article Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus.
Academic Article Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region.
Academic Article Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children.
Academic Article Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB.
Academic Article New Insights Relating Gasdermin B to the Onset of Childhood Asthma.
Academic Article Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region.
Academic Article DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma.
Academic Article African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans.
Academic Article Discerning asthma endotypes through comorbidity mapping.
Academic Article A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome.
Grant Airway inflammation and HLA-G in asthma
Grant Positional Cloning of a 6p-linked Asthma Gene
Grant Integrated genetic, omic, and immunologic studies to identify endotypes and novel drug targets for asthma and allergic diseases
Grant Training of Junior Faculty for Careers in Omics of Lung Diseases
Grant The EVE Asthma Genetics Consortium: Building Upon GWAS
Grant Genomic Studies of Sex-Specific Architecture of Asthma-Associated Traits
Academic Article Asthma-protective agents in dust from traditional farm environments.
Academic Article Revealing polygenic pleiotropy using genetic risk scores for asthma.
Academic Article Analytical challenges in omics research on asthma and allergy: A National Institute of Allergy and Infectious Diseases workshop.
Academic Article Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.
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  • severe
  • asthma