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One or more keywords matched the following properties of Wei, Wei
keywords neural circuit, neural computation, synaptic physiology, retina, motion detection, visual processing
overview How are neural circuits assembled to perform specific computations? An excellent model system to address this question is the retina, where a diverse set of neural circuits are wired with remarkable precision and intricacy to extract salient features such as color, contrast and motion from the visual scene. Each retinal circuit utilizes distinct neuronal types and conveys the processed visual information to higher brain by a specific type of retinal ganglion cells. My lab is interested in the synaptic basis of neural computation in the retina. Our current research is focused on understanding the developmental and adult patterns of synaptic connections underlying the retinal circuits, and determining how the specific wiring patterns impact visual processing. We leverage the increasing repertoire of genetic tools that label specific retinal neuron types to target the synapses of interest, and characterize the maturation and function of these synapses using a combination of techniques including multiphoton microscopy, visual stimulation, electrophysiology and molecular biology. These studies will provide insight into the neural mechanisms of visual processing in the retina, and also have broader implications in the fundamental questions of synapse development and organization in the central nervous system.
One or more keywords matched the following items that are connected to Wei, Wei
Item TypeName
Concept Action Potentials
Concept Exocytosis
Concept Evoked Potentials, Visual
Concept Neural Inhibition
Concept Motion Perception
Concept Natural Language Processing
Concept Motion
Concept Neuronal Plasticity
Concept Synaptic Transmission
Concept Female
Concept Visual Perception
Concept Retina
Concept Visual Fields
Concept Vision, Ocular
Concept Male
Concept Excitatory Postsynaptic Potentials
Concept Visual Cortex
Concept Neural Pathways
Concept Calcium Signaling
Concept Visual Pathways
Concept Transfection
Concept Long-Term Potentiation
Concept Inhibitory Postsynaptic Potentials
Concept Orientation
Concept Phenotype
Concept Signal Transduction
Academic Article Organization and development of direction-selective circuits in the retina.
Academic Article Conditional Knock-Out of Vesicular GABA Transporter Gene from Starburst Amacrine Cells Reveals the Contributions of Multiple Synaptic Mechanisms Underlying Direction Selectivity in the Retina.
Academic Article Transgenic mice reveal unexpected diversity of on-off direction-selective retinal ganglion cell subtypes and brain structures involved in motion processing.
Academic Article Development of asymmetric inhibition underlying direction selectivity in the retina.
Academic Article Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in image-forming circuits.
Academic Article Two-photon targeted recording of GFP-expressing neurons for light responses and live-cell imaging in the mouse retina.
Academic Article Genetic identification of an On-Off direction-selective retinal ganglion cell subtype reveals a layer-specific subcortical map of posterior motion.
Academic Article Stimulus-dependent recruitment of lateral inhibition underlies retinal direction selectivity.
Academic Article Retinal origin of direction selectivity in the superior colliculus.
Academic Article Neural Mechanisms of Motion Processing in the Mammalian Retina.
Academic Article Stimulus-dependent engagement of neural mechanisms for reliable motion detection in the mouse retina.
Academic Article Compartmentalized dendritic signaling in a multitasking retinal interneuron.
Academic Article Cross-compartmental Modulation of Dendritic Signals for Retinal Direction Selectivity.
Academic Article Neural mechanisms of contextual modulation in the retinal direction selective circuit.
Academic Article An atlas of nano-enabled neural interfaces.
Academic Article Decreasing Influence of Retinal Inputs on the Developing Visual Cortex.
Academic Article Dampening light sensitivity.
Academic Article Preserving inhibition with a disinhibitory microcircuit in the retina.
Academic Article Spatially displaced excitation contributes to the encoding of interrupted motion by a retinal direction-selective circuit.
Grant Circuit mechanisms for encoding naturalistic motion in the mammalian retina
Grant Synaptic basis of motion detection in the retina
Academic Article Visual stimulation induces distinct forms of sensitization of On-Off direction-selective ganglion cell responses in the dorsal and ventral retina
Academic Article Functional convergence of on-off direction-selective ganglion cells in the visual thalamus.
Academic Article Dendritic mGluR2 and perisomatic Kv3 signaling regulate dendritic computation of mouse starburst amacrine cells.
Academic Article Natural language processing to identify lupus nephritis phenotype in electronic health records.
Grant Dynamic interactions between synaptic and intrinsic properties of starburst amacrine cells for robust motion detection
Search Criteria
  • neural
  • circuit
  • neural
  • computation
  • synaptic
  • physiology
  • retina
  • motion
  • detection
  • visual
  • processing