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Search Results to Nanduri R. Prabhakar

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overview Nanduri R. Prabhakar, Ph.D., D.Sc. Harold Hines Jr. Professor of Medicine Director, Center for Systems Biology Director, Oxygen Sensing Department of Medicine The revolutionary advances in cell and molecular biology as well as in genetic engineering in the past half-a-century have provided spectacular insights into our understanding of structure and function of biological systems at the molecular, cellular and sub-cellular levels. Shifting the research emphasis from organ (or from the whole body levels) to cellular and molecular physiology has resulted in a rapid decline in research on physiology at the systems level. While the reductionist approaches are powerful, they have brought into focus a major gap that has developed between our understanding of the molecular/cellular alterations and their impact at the organ and/or whole animal level. Integrative physiology, on the other hand, embraces the concepts of cell/molecular physiology, biochemistry and applies these concepts and experimental approaches to understand the function at the level of whole animal or organ. Realizing its importance, the University of Chicago established the Institute for Integrative Physiology (IIP) at the Biological Sciences Division as of October 2010. The main missions of IIP are to provide intellectual home for faculty members interested in various areas of Physiology to foster interactive research programs and oversee physiology education to medical, graduate and undergraduate students. These missions are supported by exceptional faculty in the IIP. We believe that IIP reaches far beyond the BSD to enhance the national and international visibility of Physiological research at the University of Chicago and provide training to the next generation of leaders in Physiology.

One or more keywords matched the following items that are connected to Prabhakar, Nanduri

Item TypeName
Concept Neural Conduction
Concept Neural Tube Defects
Concept Mixed Function Oxygenases
Concept Respiratory Function Tests
Concept Neural Pathways
Academic Article Carotid body I1-imidazoline receptors: binding, visualization and modulatory function.
Academic Article Neural drives and breathing stability.
Academic Article Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha.
Academic Article The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation.
Academic Article Ventilatory changes during intermittent hypoxia: importance of pattern and duration.
Academic Article Functional role of substance P for respiratory control during development.
Academic Article Altered carotid body function by intermittent hypoxia in neonates and adults: relevance to recurrent apneas.
Academic Article Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia.
Academic Article Intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing.
Academic Article NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia.
Academic Article Long-term regulation of carotid body function: acclimatization and adaptation--invited article.
Academic Article Enhanced neuropeptide Y synthesis during intermittent hypoxia in the rat adrenal medulla: role of reactive oxygen species-dependent alterations in precursor peptide processing.
Academic Article Nitric oxide in the sensory function of the carotid body.
Academic Article Neonatal intermittent hypoxia impairs neuronal nicotinic receptor expression and function in adrenal chromaffin cells.
Academic Article Spinal termination of nociceptive afferent fibres from deep tissues in the cat.
Academic Article Peripheral chemoreceptors: function and plasticity of the carotid body.
Academic Article Regulation of hypoxia-inducible factor-a isoforms and redox state by carotid body neural activity in rats.
Academic Article TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.
Academic Article Impairment of pancreatic ß-cell function by chronic intermittent hypoxia.
Academic Article Role of oxidative stress-induced endothelin-converting enzyme activity in the alteration of carotid body function by chronic intermittent hypoxia.
Academic Article Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea.
Academic Article Chronic Intermittent Hypoxia Alters Local Respiratory Circuit Function at the Level of the preBötzinger Complex.
Academic Article DNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity.
Academic Article Neural Activation of Molecular Circuitry in Intermittent Hypoxia.

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