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One or more keywords matched the following properties of Solway, Julian
overview Walter L. Palmer Distinguished Service Professor of Medicine and Pediatrics Dean for Translational Medicine Director, Institute for Translational Medicine I am Dean for Translational Medicine and founding Director of the Institute for Translational Medicine, home of the University of Chicago-Rush University NIH/NCATS CTSA award. I have served the CTSA Consortium as a co-Chair, Steering Committee member, and co-Chair of the Strategic Goal 3 and Collaboration/Engagement Domain Task Force. My research programs primarily address asthma. I have extensive experience studying airway smooth muscle (ASM) function and dysfunction in asthma, having studied smooth muscle specific gene transcription, protein accumulation, and hypertrophy, and signaling mechanisms that regulate these; ASM contraction and its reversal, and the mechanisms that regulate these; and ASM mediated-airway narrowing, airway constrictor responsiveness, and lung function in both animal models and humans. Additional studies address asthma genetics and therapeutics in mechanistic and therapeutic clinical studies and preclinical development of novel asthma treatments. Recently, I have focused on the inhibition of pulmonary fibrosis and on the inhibition of breast cancer metastasis using novel small molecules discovered in our asthma studies. I directed the University of Chicago's NHLBI-sponsored T32 Research Training Program in Respiratory Biology for 25 years, led or co-led two NHLBI Multidisciplinary K12 Training Programs, co-led an NIH Broadening Experiences in Scientific Training (BEST) award, and currently lead a Burroughs Wellcome Fund Physician Scientist Institutional Award. My ORCID is 0000-0002-0898-8530. My Scopus ID is 7006796752. My NIH COMMONS name is jsolway. BS 1974 Massachusetts Institute of Technology (Electrical Engineering) MD cum laude 1978 Harvard University (Medicine) Residency 1981 Brigham and Women's Hospital (Internal Medicine) Fellowship 1983 Harvard Medical School (Pulmonary Medicine)
One or more keywords matched the following items that are connected to Solway, Julian
Item TypeName
Concept Asthma, Exercise-Induced
Concept Asthma
Academic Article Perhaps airway smooth muscle dysfunction contributes to asthmatic bronchial hyperresponsiveness after all.
Academic Article Bronchoalveolar lavage fluid from asthmatic subjects is mitogenic for human airway smooth muscle.
Academic Article Transcriptional regulation of smooth muscle contractile apparatus expression.
Academic Article Mutagenesis analysis of human SM22: characterization of actin binding.
Academic Article What makes the airways contract abnormally? Is it inflammation?
Academic Article Ethnic differences in asthma and associated phenotypes: collaborative study on the genetics of asthma.
Academic Article Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons.
Academic Article Genome-wide linkage analyses of total serum IgE using variance components analysis in asthmatic families.
Academic Article Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations.
Academic Article The nasal passage of subjects with asthma has a decreased ability to warm and humidify inspired air.
Academic Article beta(2)-adrenergic receptor Arg16/Arg16 genotype is associated with reduced lung function, but not with asthma, in the Hutterites.
Academic Article Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations: collaborative study on the genetics of asthma.
Academic Article Clinical practice. Mild asthma.
Academic Article Actin dynamics: a potential integrator of smooth muscle (Dys-)function and contractile apparatus gene expression in asthma. Parker B. Francis lecture.
Academic Article Sequence variation in the promoter region of the cholinergic receptor muscarinic 3 gene and asthma and atopy.
Academic Article Serum response factor function and dysfunction in smooth muscle.
Academic Article Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma?
Academic Article A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma.
Academic Article Treatment of nasal inflammation decreases the ability of subjects with asthma to condition inspired air.
Academic Article Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma.
Academic Article Methodologic advancements in the study of airway smooth muscle.
Academic Article What evidence implicates airway smooth muscle in the cause of BHR?
Academic Article Breathing pattern affects respiratory heat loss but not bronchoconstrictor response in asthma.
Academic Article Airway smooth muscle as a target for asthma therapy.
Academic Article Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma.
Academic Article Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation.
Academic Article Airway smooth muscle in asthma.
Academic Article Myosin, transgelin, and myosin light chain kinase: expression and function in asthma.
Academic Article Disrupting actin-myosin-actin connectivity in airway smooth muscle as a treatment for asthma?
Academic Article p70 Ribosomal S6 kinase is required for airway smooth muscle cell size enlargement but not increased contractile protein expression.
Academic Article Fas-positive T cells regulate the resolution of airway inflammation in a murine model of asthma.
Academic Article Differential induction of CD38 expression by TNF-{alpha} in asthmatic airway smooth muscle cells.
Academic Article Allele-specific targeting of microRNAs to HLA-G and risk of asthma.
Academic Article Force fluctuation-induced relengthening of acetylcholine-contracted airway smooth muscle.
Academic Article Dilatation of the constricted human airway by tidal expansion of lung parenchyma.
Academic Article miR-140-3p regulation of TNF-a-induced CD38 expression in human airway smooth muscle cells.
Academic Article Dissociation of temperature-gradient and evaporative heat loss during cold gas hyperventilation in cold-induced asthma.
Academic Article Steroids augment relengthening of contracted airway smooth muscle: potential additional mechanism of benefit in asthma.
Academic Article Finite difference analysis of respiratory heat transfer.
Academic Article Calcium channel blocking agents in bronchial hyperreactivity.
Academic Article Bronchoconstriction elicited by isocapnic hyperpnea in guinea pigs.
Academic Article Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscle.
Academic Article Persistent airway hyperresponsiveness and histologic alterations after chronic antigen challenge in cats.
Academic Article Bronchoconstrictor effects of leukotriene E4 in normal and asthmatic subjects.
Academic Article Air conditioning and exercise-induced asthma.
Academic Article Phophatidylinositol-3 kinase/mammalian target of rapamycin/p70S6K regulates contractile protein accumulation in airway myocyte differentiation.
Academic Article Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.
Academic Article Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.
Academic Article Emerging targets for novel therapy of asthma.
Academic Article Airway smooth muscle in the pathophysiology and treatment of asthma.
Academic Article Maternal asthma and microRNA regulation of soluble HLA-G in the airway.
Academic Article Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial.
Academic Article Gata5 deficiency causes airway constrictor hyperresponsiveness in mice.
Academic Article Airway smooth muscle: a potential target for asthma therapy.
Academic Article E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation.
Academic Article A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes.
Academic Article Genome-wide interrogation of longitudinal FEV1 in children with asthma.
Academic Article MicroRNA-146a and microRNA-146b expression and anti-inflammatory function in human airway smooth muscle.
Academic Article Cyclooxygenase-2 and microRNA-155 expression are elevated in asthmatic airway smooth muscle cells.
Academic Article High-throughput screening for modulators of cellular contractile force.
Academic Article Future Research Directions in Asthma. An NHLBI Working Group Report.
Academic Article Genome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways.
Academic Article Corticosteroid therapy and airflow obstruction influence the bronchial microbiome, which is distinct from that of bronchoalveolar lavage in asthmatic airways.
Academic Article An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma.
Academic Article DNA methylation in lung cells is associated with asthma endotypes and genetic risk.
Academic Article Elevated levels of soluble humanleukocyte antigen-G in the airways are a marker for a low-inflammatory endotype of asthma.
Grant Mendelian Disease - Asthma Comorbidity to Find Subgroup-Specific Asthma Genes
Academic Article Associations between environmental quality and adult asthma prevalence in medical claims data.
Grant Preclinical development of myosolvins, a new class of medicine for asthma
Grant Dissecting the Genetic Architecture of Airway Hyperresponsiveness
Grant Chicago Metropolitan Asthma Consortium for severe / exacerbation-prone asthma
Academic Article Loss of bronchoprotection with ICS plus LABA treatment, ß-receptor dynamics, and the effect of alendronate.
Academic Article Evidence for an IL-6-high asthma phenotype in asthmatic patients of African ancestry.
Academic Article Associations between fungal and bacterial microbiota of airways and asthma endotypes.
Academic Article Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.
Academic Article Role of Isocitrate Dehydrogenase 2 on DNA Hydroxymethylation in Human Airway Smooth Muscle Cells.
Academic Article Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma.
Academic Article Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma.
Academic Article Discerning asthma endotypes through comorbidity mapping.
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  • severe
  • asthma