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One or more keywords matched the following properties of Ruthenburg, Alexander J.
PropertyValue
keywords Chromatin Associated RNA
keywords Chromatin
keywords Chromatin Immunoprecipitation
overview The unifying theme of my lab is the elucidation of molecular mechanisms underlying management chromatin, the physiological form of the genome. In particular, we are interested in how post translational modifications to histones, newly appreciated DNA modifications and noncoding RNA can control chromatin structure. Our research spans several traditional disciplines, ranging from discovery biochemistry and genome-scale measurements to mechanistic characterization with biophysical methods coupled with X-Ray structure to address fundamental questions in chromatin biology. We have pioneered new technologies to make quantitative local measurements of chromatin components. Projects ideally will transition from discovery biology to detailed molecular and structural investigation.
One or more keywords matched the following items that are connected to Ruthenburg, Alexander J.
Item TypeName
Concept Chromatin Assembly and Disassembly
Academic Article How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers.
Academic Article Multivalent engagement of chromatin modifications by linked binding modules.
Academic Article Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions.
Academic Article Validation of histone-binding partners by peptide pull-downs and isothermal titration calorimetry.
Academic Article Calibrating ChIP-Seq with Nucleosomal Internal Standards to Measure Histone Modification Density Genome Wide.
Academic Article Nuclear Fractionation Reveals Thousands of Chromatin-Tethered Noncoding RNAs Adjacent to Active Genes.
Academic Article Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription.
Grant Quantitatively probing intra-nucleosomal chromatin variation and function
Grant Internally calibrated chromatin immunoprecipitation using barcoded nucleosomes
Grant Calibrated ChIP-seq: determining local histone modification density genome-wide
Academic Article Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies.
Academic Article Native internally calibrated chromatin immunoprecipitation for quantitative studies of histone post-translational modifications.
Academic Article Chromatin-enriched RNAs mark active and repressive cis-regulation: An analysis of nuclear RNA-seq.
Academic Article Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription.
Academic Article Sequence deeper without sequencing more: Bayesian resolution of ambiguously mapped reads.
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  • Chromatin