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Thornton, Joseph

One or more keywords matched the following properties of Thornton, Joseph

Property	Value
keywords	Molecular Evolution
keywords	Evolution, Genetic

One or more keywords matched the following items that are connected to Thornton, Joseph

Item Type	Name
Concept	Evolution, Molecular
Concept	Directed Molecular Evolution
Academic Article	Evolution of increased complexity in a molecular machine.
Academic Article	Evolution of the androgen receptor: structure-function implications.
Academic Article	Evolution of a new function by degenerative mutation in cephalochordate steroid receptors.
Academic Article	An evolvable oestrogen receptor activity sensor: development of a modular system for integrating multiple genes into the yeast genome.
Academic Article	Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
Academic Article	Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
Academic Article	Evolution of steroid receptors from an estrogen-sensitive ancestral receptor.
Academic Article	The interface of protein structure, protein biophysics, and molecular evolution.
Academic Article	Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor.
Academic Article	Crystal structure of an ancient protein: evolution by conformational epistasis.
Academic Article	Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors.
Academic Article	No magic pill for phylogenetic error.
Academic Article	Thermodynamic system drift in protein evolution.
Academic Article	Mechanistic approaches to the study of evolution: the functional synthesis.
Academic Article	An epistatic ratchet constrains the direction of glucocorticoid receptor evolution.
Academic Article	Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor.
Academic Article	A mixed branch length model of heterotachy improves phylogenetic accuracy.
Academic Article	Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions.
Academic Article	Historical contingency and its biophysical basis in glucocorticoid receptor evolution.
Academic Article	Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor.
Academic Article	Evolution of hormone-receptor complexity by molecular exploitation.
Academic Article	Is there a star tree paradox?
Academic Article	Analyzing protein structure and function using ancestral gene reconstruction.
Academic Article	Evolution of minimal specificity and promiscuity in steroid hormone receptors.
Academic Article	The Octopus vulgaris estrogen receptor is a constitutive transcriptional activator: evolutionary and functional implications.
Academic Article	Resurrecting the ancestral steroid receptor: ancient origin of estrogen signaling.
Academic Article	Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites.
Academic Article	Evolution of an ancient protein function involved in organized multicellularity in animals.
Academic Article	Epistasis in protein evolution.
Academic Article	Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty.
Academic Article	Reconstructing Ancient Proteins to Understand the Causes of Structure and Function.
Academic Article	Alternative evolutionary histories in the sequence space of an ancient protein.
Academic Article	Evolution of protein specificity: insights from ancestral protein reconstruction.
Academic Article	Multinucleotide mutations cause false inferences of lineage-specific positive selection.
Academic Article	Pervasive contingency and entrenchment in a billion years of Hsp90 evolution.
Academic Article	A second estrogen receptor from Japanese lamprey (Lethenteron japonicum) does not have activities for estrogen binding and transcription.
Academic Article	Ancient mechanisms for the evolution of the bicoid homeodomain's function in fly development.
Academic Article	Origin of complexity in haemoglobin evolution.
Academic Article	A hydrophobic ratchet entrenches molecular complexes.
Academic Article	Contingency and chance erase necessity in the experimental evolution of ancestral proteins.
Academic Article	Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors.
Academic Article	Epistatic drift causes gradual decay of predictability in protein evolution.
Academic Article	Simple mechanisms for the evolution of protein complexity.
Grant	Deep characterization of the sequence space and evolutionary trajectories of reconstructed ancestral proteins - Resubmission 01
Grant	Experimental evolution of ligand-receptor relationships
Academic Article	Evolutionary Shortcuts via Multinucleotide Substitutions and Their Impact on Natural Selection Analyses.

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Molecular Evolution