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Piccirilli, Joseph A.
One or more keywords matched the following items that are connected to Piccirilli, Joseph A.
Item TypeName
Concept Introns
Academic Article RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization.
Academic Article Metal ion catalysis in the Tetrahymena ribozyme reaction.
Academic Article Metal ion coordination by the AGC triad in domain 5 contributes to group II intron catalysis.
Academic Article Leaving group stabilization by metal ion coordination and hydrogen bond donation is an evolutionarily conserved feature of group I introns.
Academic Article Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome.
Academic Article Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: extending the parallels between the spliceosome and group II introns.
Academic Article A second divalent metal ion in the group II intron reaction center.
Academic Article Synthesis and biochemical application of 2'-O-methyl-3'-thioguanosine as a probe to explore group I intron catalysis.
Academic Article Structure and function converge to identify a hydrogen bond in a group I ribozyme active site.
Academic Article Biochemistry. Toward understanding self-splicing.
Academic Article Functional identification of ligands for a catalytic metal ion in group I introns.
Academic Article Metal-ion rescue revisited: biochemical detection of site-bound metal ions important for RNA folding.
Academic Article Modulation of individual steps in group I intron catalysis by a peripheral metal ion.
Academic Article Kinetic characterization of the second step of group II intron splicing: role of metal ions and the cleavage site 2'-OH in catalysis.
Academic Article New strategies for exploring RNA's 2'-OH expose the importance of solvent during group II intron catalysis.
Academic Article The 2'-hydroxyl group of the guanosine nucleophile donates a functionally important hydrogen bond in the tetrahymena ribozyme reaction.
Academic Article RNA catalyses nuclear pre-mRNA splicing.
Academic Article Evidence for a group II intron-like catalytic triplex in the spliceosome.
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  • Intron