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One or more keywords matched the following properties of Schreiber, Hans
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overview The main focus of this laboratory is to study the fundamental mechanisms that govern the interaction of cancer cells with the immune system. In particular, our laboratory is trying to exploit the fact that cancer cells usually carry cancer-specific mutations and antigens, and that under certain conditions, the immune system can destroy cancer cells even after they have disseminated in the body. We are trying to understand the mechanisms that often allow immunogenic cancer cells to escape immune destruction, and we want to develop new strategies and principles on which to base novel therapeutic approaches. We are also studying the signals needed for the immune system to be alerted be cancer cells, and then to destroy these cells. Finally, we combine immunology with genetics and biochemistry, which provides us with a powerful tool to search for cancer-specific changes in malignant cells in order to identify critical mechanisms and immunological targets that can be used to destroy the cancer.
One or more keywords matched the following items that are connected to Schreiber, Hans
Item TypeName
Concept Alleles
Concept Amino Acid Sequence
Concept Base Sequence
Concept Oncogenes
Concept Genes, MHC Class I
Concept Models, Molecular
Concept Molecular Sequence Data
Concept Major Histocompatibility Complex
Concept Transplantation Immunology
Concept Sequence Homology, Amino Acid
Concept Genes, Suppressor
Concept Genes, Reporter
Concept Molecular Chaperones
Concept Genes, p53
Concept Directed Molecular Evolution
Academic Article A tumor escape variant that has lost one major histocompatibility complex class I restriction element induces specific CD8+ T cells to an antigen that no longer serves as a target.
Academic Article Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice.
Academic Article DNA sequence analysis of T-cell receptor genes reveals an oligoclonal T-cell response to a tumor with multiple target antigens.
Academic Article Footprinting of individual tumors and their variants by constitutive cytokine expression patterns.
Academic Article The immunodominant antigen of an ultraviolet-induced regressor tumor is generated by a somatic point mutation in the DEAD box helicase p68.
Academic Article Tracking the common ancestry of antigenically distinct cancer variants.
Academic Article Point mutation in essential genes with loss or mutation of the second allele: relevance to the retention of tumor-specific antigens.
Academic Article Ribosomal versus non-ribosomal cellular antigens: factors determining efficiency of indirect presentation to CD4+ T cells.
Academic Article A mutant chaperone converts a wild-type protein into a tumor-specific antigen.
Academic Article Antibody recognition of a unique tumor-specific glycopeptide antigen.
Academic Article A unique tumor antigen produced by a single amino acid substitution.
Academic Article Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction.
Academic Article Versatile cyclic templates for assembly of axially oriented ligands.
Academic Article CD4(+) T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma.
Academic Article Major histocompatibility complex class I and unique antigen expression by murine tumors that escaped from CD8+ T-cell-dependent surveillance.
Academic Article Editorial overview: tumour immunology.
Academic Article Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides.
Grant Manipulation of Tumor Specific Immunity
Grant Interdisciplinary Training Program in Immunology
Grant IMMUNITY AND CANCER
Grant MANIPULATION OF TUMOR-SPECIFIC IMMUNITY
Grant Immunology of Unique Tumor Specific Antigens
Search Criteria
  • Molecular
  • Immunology