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One or more keywords matched the following properties of Lengyel, Ernst Robert
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overview I trained both as a scientist and as a physician and, throughout my career, I have focused on the treatment and biology of ovarian cancer (OvCa). My Ph.D. thesis was on the role of proteases in ovarian cancer and my clinical fellowship involved a special emphasis on the treatment of patients with this disease. As a surgeon and clinician, I am familiar with the presentation of ovarian cancer in patients, and experience the incredible obstacles we face in its treatment. In the laboratory, I have built the research infrastructure necessary for effective ovarian cancer research. The Lengyel lab has elucidated, at least in part, the first critical steps of ovarian cancer metastasis by paying close attention to the host microenvironment. We have collected the 25 most commonly used ovarian cancer cell lines from all over the world, including those which are chemotherapy resistant. We have established several mouse models for OvCa, and using a genetic mouse model (K-rasG12D/+/Pten-/- -- established by Dr. Tyler Jacks), a syngeneic orthotopic mouse model using mouse OvCa cells (ID8 -- established by K. Roby), and several xenograft ip models using primary and cultured human OvCa cells. I have also established a prospective OvCa tissue bank and, together with 2 gynecologic pathologists, we have assembled 13 tissue arrays including normal tissue, borderline tumor and primary tumor, & corresponding metastasis. As a surgeon, the main focus of my practice is patients with OvCa; therefore, I will be able to enroll a substantial number of patients on the proposed clinical trial and have the infrastructure in place to collect the tissue required for the translational studies. My clinical experience treating ovarian cancer, together with my laboratory, which focuses on OvCa biology, gives me a unique opportunity and obligation to find new treatments that can benefit patients with ovarian cancer.
One or more keywords matched the following items that are connected to Lengyel, Ernst Robert
Item TypeName
Concept Breast Neoplasms
Concept Bone Neoplasms
Concept Urinary Bladder Neoplasms
Concept Fallopian Tube Neoplasms
Concept Colonic Neoplasms
Concept Uterine Cervical Neoplasms
Concept Gastrointestinal Neoplasms
Concept Genital Neoplasms, Female
Concept Colorectal Neoplasms, Hereditary Nonpolyposis
Concept Liver Neoplasms
Concept Ovarian Neoplasms
Concept Lung Neoplasms
Concept Uterine Neoplasms
Concept Testicular Neoplasms
Concept Drug Resistance, Neoplasm
Concept Brain Stem Neoplasms
Concept Endometrial Neoplasms
Concept Neoplasms, Experimental
Concept Peritoneal Neoplasms
Concept Colorectal Neoplasms
Concept Thyroid Neoplasms
Concept Neoplasms, Bone Tissue
Concept Neoplasms
Concept Neoplasms, Glandular and Epithelial
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Academic Article An orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasis.
Academic Article MMP-2 functions as an early response protein in ovarian cancer metastasis.
Academic Article Combination analysis of activator protein-1 family members, Sp1 and an activator protein-2alpha-related factor binding to different regions of the urokinase receptor gene in resected colorectal cancers.
Academic Article Effects of oral contraceptives or a gonadotropin-releasing hormone agonist on ovarian carcinogenesis in genetically engineered mice.
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Academic Article c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion.
Academic Article A phase II, single-arm study of the anti-a5ß1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer.
Academic Article Let-7 expression defines two differentiation stages of cancer.
Academic Article Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1.
Academic Article Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target.
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Academic Article Foretinib (GSK1363089), an orally available multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis.
Academic Article FOXL2 and SOX9 distinguish the lineage of the sex cord-stromal cells in gonadoblastomas.
Academic Article A special key for unlocking the door to targeted therapies of breast cancer.
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Academic Article Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Academic Article {beta}3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer.
Academic Article Targeting the urokinase plasminogen activator receptor inhibits ovarian cancer metastasis.
Academic Article Rethinking ovarian cancer: recommendations for improving outcomes.
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Academic Article Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra-cellular matrices on adhesion and invasion of ovarian cancer cells to the omentum.
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Academic Article The molecular signature of endometriosis-associated endometrioid ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer.
Academic Article Ovarian cancer development and metastasis.
Academic Article The expression of hepatocyte growth factor (HGF) and c-Met in uterine serous carcinoma.
Academic Article HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts.
Academic Article Differential expression of c-Met, its ligand HGF/SF and HER2/neu in DCIS and adjacent normal breast tissue.
Academic Article A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings.
Academic Article Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation.
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Academic Article Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity.
Academic Article Angiography-proven liver metastases explain low efficacy of lymph node dissections in medullary thyroid cancer patients.
Academic Article miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin a5 expression.
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Academic Article MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer.
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Academic Article Expression of the homeobox gene HOXA9 in ovarian cancer induces peritoneal macrophages to acquire an M2 tumor-promoting phenotype.
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Academic Article Utility of routine surveillance methods in detecting recurrence in high grade endometrial cancer patients.
Academic Article Three-dimensional modeling of ovarian cancer.
Academic Article Urokinase plasminogen activator system-targeted delivery of nanobins as a novel ovarian cancer therapy.
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Academic Article WNT7A/ß-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer.
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Academic Article Summary of the 2013 American Association for Cancer Research (AACR) Annual Meeting.
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Academic Article [Juvenile aneuploid papillary cancer of the thyroid with pulmonary metastasis].
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Academic Article Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.
Academic Article Exosomes Promote Ovarian Cancer Cell Invasion through Transfer of CD44 to Peritoneal Mesothelial Cells.
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Academic Article Genomics of Ovarian Cancer Progression Reveals Diverse Metastatic Trajectories Including Intraepithelial Metastasis to the Fallopian Tube.
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Academic Article Unsaturated Fatty Acids Maintain Cancer Cell Stemness.
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Academic Article Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.
Academic Article New Roles for Glycogen in Tumor Progression.
Academic Article Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis.
Academic Article Ultrasensitive, multiplexed chemoproteomic profiling with soluble activity-dependent proximity ligation.
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Academic Article Mesothelial Cell HIF1a Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk.
Academic Article Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake.
Academic Article Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance.
Academic Article A streamlined mass spectrometry-based proteomics workflow for large-scale FFPE tissue analysis.
Academic Article Are We Ready for Hyperthermic Intraperitoneal Chemotherapy in the Upfront Treatment of Ovarian Cancer?
Academic Article Complete Response in a Patient With Chemorefractory EGFR-Amplified, PD-L1-Positive Metastatic Gastric Cancer Treated By Dual Anti-EGFR and Anti-PD-1 Monoclonal Antibody Therapy.
Academic Article Updates and New Options in Advanced Epithelial Ovarian Cancer Treatment.
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Academic Article The Effects of Chemotherapeutics on the Ovarian Cancer Microenvironment.
Academic Article The Natural Product ß-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis.
Academic Article Germline mutations in Black patients with ovarian, fallopian tube and primary peritoneal carcinomas.
Academic Article Neoadjuvant Chemotherapy Induces Genomic and Transcriptomic Changes in Ovarian Cancer.
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Concept Cancer-Associated Fibroblasts
Concept Cancer Survivors
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Academic Article Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis.
Academic Article 5-Hydroxymethylcytosine signals in serum are a predictor of chemoresistance in high-grade serous ovarian cancer.
Academic Article Tumor microenvironment-induced FOXM1 regulates ovarian cancer stemness.
Academic Article Molecular changes driving low-grade serous ovarian cancer and implications for treatment.
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