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Search Results to Ernst Robert Lengyel

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overview I trained both as a scientist and as a physician and, throughout my career, I have focused on the treatment and biology of ovarian cancer (OvCa). My Ph.D. thesis was on the role of proteases in ovarian cancer and my clinical fellowship involved a special emphasis on the treatment of patients with this disease. As a surgeon and clinician, I am familiar with the presentation of ovarian cancer in patients, and experience the incredible obstacles we face in its treatment. In the laboratory, I have built the research infrastructure necessary for effective ovarian cancer research. The Lengyel lab has elucidated, at least in part, the first critical steps of ovarian cancer metastasis by paying close attention to the host microenvironment. We have collected the 25 most commonly used ovarian cancer cell lines from all over the world, including those which are chemotherapy resistant. We have established several mouse models for OvCa, and using a genetic mouse model (K-rasG12D/+/Pten-/- -- established by Dr. Tyler Jacks), a syngeneic orthotopic mouse model using mouse OvCa cells (ID8 -- established by K. Roby), and several xenograft ip models using primary and cultured human OvCa cells. I have also established a prospective OvCa tissue bank and, together with 2 gynecologic pathologists, we have assembled 13 tissue arrays including normal tissue, borderline tumor and primary tumor, & corresponding metastasis. As a surgeon, the main focus of my practice is patients with OvCa; therefore, I will be able to enroll a substantial number of patients on the proposed clinical trial and have the infrastructure in place to collect the tissue required for the translational studies. My clinical experience treating ovarian cancer, together with my laboratory, which focuses on OvCa biology, gives me a unique opportunity and obligation to find new treatments that can benefit patients with ovarian cancer.

One or more keywords matched the following items that are connected to Lengyel, Ernst Robert

Item TypeName
Concept Ovarian Neoplasms
Academic Article Integrin alpha(v)beta(3)/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells.
Academic Article Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer.
Academic Article Expression of latent matrix metalloproteinase 9 (MMP-9) predicts survival in advanced ovarian cancer.
Academic Article Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2.
Academic Article Does equal treatment yield equal outcomes? The impact of race on survival in epithelial ovarian cancer.
Academic Article The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin.
Academic Article An orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasis.
Academic Article MMP-2 functions as an early response protein in ovarian cancer metastasis.
Academic Article Effects of oral contraceptives or a gonadotropin-releasing hormone agonist on ovarian carcinogenesis in genetically engineered mice.
Academic Article CD95 promotes tumour growth.
Academic Article c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion.
Academic Article A phase II, single-arm study of the anti-a5ß1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer.
Academic Article Let-7 expression defines two differentiation stages of cancer.
Academic Article Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1.
Academic Article Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target.
Academic Article Ligand-independent activation of c-Met by fibronectin and a(5)ß(1)-integrin regulates ovarian cancer invasion and metastasis.
Academic Article Foretinib (GSK1363089), an orally available multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis.
Academic Article The effects of 17ß-estradiol and a selective estrogen receptor modulator, bazedoxifene, on ovarian carcinogenesis.
Academic Article Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Academic Article {beta}3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer.
Academic Article Targeting the urokinase plasminogen activator receptor inhibits ovarian cancer metastasis.
Academic Article Rethinking ovarian cancer: recommendations for improving outcomes.
Academic Article Involvement of a mitogen-activated protein kinase signaling pathway in the regulation of urokinase promoter activity by c-Ha-ras.
Academic Article The first line of intra-abdominal metastatic attack: breaching the mesothelial cell layer.
Academic Article Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra-cellular matrices on adhesion and invasion of ovarian cancer cells to the omentum.
Academic Article The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2.
Academic Article The molecular signature of endometriosis-associated endometrioid ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer.
Academic Article Ovarian cancer development and metastasis.
Academic Article HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts.
Academic Article A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings.
Academic Article Organotypic models of metastasis: A three-dimensional culture mimicking the human peritoneum and omentum for the study of the early steps of ovarian cancer metastasis.
Academic Article Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity.
Academic Article miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin a5 expression.
Academic Article Serial sectioning of the fallopian tube allows for improved identification of primary fallopian tube carcinoma.
Academic Article MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer.
Academic Article Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion.
Academic Article Expression of the homeobox gene HOXA9 in ovarian cancer induces peritoneal macrophages to acquire an M2 tumor-promoting phenotype.
Academic Article Three-dimensional modeling of ovarian cancer.
Academic Article Urokinase plasminogen activator system-targeted delivery of nanobins as a novel ovarian cancer therapy.
Academic Article Epithelial ovarian cancer experimental models.
Academic Article WNT7A/ß-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer.
Academic Article Statin therapy is associated with improved survival in patients with non-serous-papillary epithelial ovarian cancer: a retrospective cohort analysis.
Academic Article Summary of the 2013 American Association for Cancer Research (AACR) Annual Meeting.
Academic Article Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models.
Academic Article Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.
Academic Article Whole-genome characterization of chemoresistant ovarian cancer.
Academic Article The hypoxia-related microRNA miR-199a-3p displays tumor suppressor functions in ovarian carcinoma.
Academic Article Glucocorticoid receptor activation inhibits chemotherapy-induced cell death in high-grade serous ovarian carcinoma.
Academic Article Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer.
Academic Article Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer.
Academic Article Microenvironment-induced downregulation of miR-193b drives ovarian cancer metastasis.
Academic Article Corrigendum: Whole-genome characterization of chemoresistant ovarian cancer.
Academic Article Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity.
Academic Article Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.
Academic Article Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.
Academic Article Exosomes Promote Ovarian Cancer Cell Invasion through Transfer of CD44 to Peritoneal Mesothelial Cells.
Academic Article Reversal of Chemoresistance in Ovarian Cancer by Co-Delivery of a P-Glycoprotein Inhibitor and Paclitaxel in a Liposomal Platform.
Academic Article Genomics of Ovarian Cancer Progression Reveals Diverse Metastatic Trajectories Including Intraepithelial Metastasis to the Fallopian Tube.
Academic Article Ovarian cancer treatment in black and white women: A comparison of clinico-pathologic factors and outcome.
Academic Article Prolactin Receptor-Mediated Internalization of Imaging Agents Detects Epithelial Ovarian Cancer with Enhanced Sensitivity and Specificity.
Academic Article Loss of BRCA1 in the Cells of Origin of Ovarian Cancer Induces Glycolysis: A Window of Opportunity for Ovarian Cancer Chemoprevention.
Academic Article A High-Throughput Screening Model of the Tumor Microenvironment for Ovarian Cancer Cell Growth.
Academic Article High glucocorticoid receptor expression predicts short progression-free survival in ovarian cancer.
Academic Article Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer.
Academic Article Induction of Neoantigen-Specific Cytotoxic T Cells and Construction of T-cell Receptor-Engineered T Cells for Ovarian Cancer.
Academic Article A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns.
Academic Article Who are the long-term survivors of high grade serous ovarian cancer?
Academic Article Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis.
Academic Article The road to long-term survival: Surgical approach and longitudinal treatments of long-term survivors of advanced-stage serous ovarian cancer.
Academic Article Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.
Academic Article The Tumor Microenvironment Takes Center Stage in Ovarian Cancer Metastasis.
Academic Article Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum.
Academic Article SPHK1 Is a Novel Target of Metformin in Ovarian Cancer.
Academic Article Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference.
Academic Article Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis.
Academic Article Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.
Academic Article Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis.
Academic Article Mesothelial Cell HIF1a Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk.
Academic Article Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance.
Academic Article Are We Ready for Hyperthermic Intraperitoneal Chemotherapy in the Upfront Treatment of Ovarian Cancer?
Academic Article Updates and New Options in Advanced Epithelial Ovarian Cancer Treatment.
Academic Article The Ratio of Toxic-to-Nontoxic miRNAs Predicts Platinum Sensitivity in Ovarian Cancer.
Academic Article The Effects of Chemotherapeutics on the Ovarian Cancer Microenvironment.
Academic Article The Natural Product ß-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis.
Academic Article Neoadjuvant chemotherapy induces genomic and transcriptomic changes in ovarian cancer.

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  • Ovarian Cancer