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Search Results to Dominique Missiakas

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overview Dr. Missiakas’s research program examines the Gram-positive pathogens Staphylococcus aureus and Bacillus anthracis. This program seeks to appreciate the biogenesis of the envelope of these microorganisms as well as the secretion of their virulence factors and host pathways targeted by these pathogens. Pathogenesis and vaccine studies in S. aureus: Many molecules in the envelope of these bacteria affect their interactions with the host. In staphylococci, cell wall anchored proteins contribute to pathogen survival in blood, dissemination to tissues, formation of abscesses and persistence in host tissues as well as subversion of immune functions. The systematic analysis of mutants lacking all or anyone of twenty cell wall anchored proteins has proven a very powerful approach in identifying protective antigens for vaccine design and elucidating virulence pathways. S. aureus is the only bacterial pathogen known to coagulate plasma and to agglutinate with fibrin cables in blood. A molecular examination of agglutination revealed that this process requires the secreted products of the coa (coagulase), vwb (von Willebrand binding protein), and clfA (Clumping factor A) genes. We are examining a model whereby S. aureus agglutination involves the formation of staphylothrombin (Coa, vWbp)-assembled fibrin cables, capped by clumping factor A (ClfA) on the staphylococcal surface and crosslinked by factor XIII. In this model, S. aureus agglutination provides for escape from phagocytic killing and bacterial traffic across the vasculature. In this manner, the Coa-vWbp-ClfA mediated agglutination pathway promotes the formation of abscess lesions, where S. aureus replicates as a fibrin encapsulated bacterial community, protected from immune cells. This key virulence strategy can be perturbed with monoclonal antibodies and small molecule inhibitors to either prevent or treat S. aureus sepsis Cell envelope assembly: Bacteria assemble polymers in their envelope that are important for their viability as well as their interaction with hosts. Our research program combines bacterial genetics, physiology and biochemistry as well as small molecule chemical tools approaches to characterize the complex biochemical pathways that enable envelope assembly in Gram-positive microbes. Potential innovations derived from this work are the identification of key enzymes for the biosynthesis of lipoteichoic acid (LTA), wall teichoic acid (WTA), secondary cell wall polysaccharide (SCWP) and capsular polymer (CPS, PDGA). In Bacilli, the SCWP is also involved in the retention of proteins that bear the S-layer homology domain (SLH proteins). SLH proteins play important function for cell separation, sporulation as well as virulence. Protein secretion: One aspect of this program examines a Sec-independent secretion system named ESAT-6 like Secretion System (ESS). Biochemical and genetic approaches are used to isolate and characterize the ESS translocon, identify secreted substrates and elucidate their function during infection of hosts.

One or more keywords matched the following items that are connected to Missiakas, Dominique

Item TypeName
Concept Respiratory Tract Infections
Concept Staphylococcal Skin Infections
Concept Surgical Wound Infection
Concept Staphylococcal Infections
Concept Gram-Positive Bacterial Infections
Concept Soft Tissue Infections
Concept Rickettsia Infections
Concept Catheter-Related Infections
Academic Article EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections.
Academic Article Staphylococcus aureus virulence genes identified by bursa aurealis mutagenesis and nematode killing.
Academic Article Host defenses against Staphylococcus aureus infection require recognition of bacterial lipoproteins.
Academic Article EsaC substrate for the ESAT-6 secretion pathway and its role in persistent infections of Staphylococcus aureus.
Academic Article Nontoxigenic protein A vaccine for methicillin-resistant Staphylococcus aureus infections in mice.
Academic Article EsaD, a secretion factor for the Ess pathway in Staphylococcus aureus.
Academic Article Identifying protective antigens of Staphylococcus aureus, a pathogen that suppresses host immune responses.
Academic Article Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues.
Academic Article Staphylococcus aureus secretes coagulase and von Willebrand factor binding protein to modify the coagulation cascade and establish host infections.
Academic Article Preventing Staphylococcus aureus sepsis through the inhibition of its agglutination in blood.
Academic Article Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus.
Academic Article A play in four acts: Staphylococcus aureus abscess formation.
Academic Article Protein A-specific monoclonal antibodies and prevention of Staphylococcus aureus disease in mice.
Academic Article Exploring Staphylococcus aureus pathways to disease for vaccine development.
Academic Article Coagulases as determinants of protective immune responses against Staphylococcus aureus.
Academic Article Contribution of coagulases towards Staphylococcus aureus disease and protective immunity.
Academic Article Abscess formation and alpha-hemolysin induced toxicity in a mouse model of Staphylococcus aureus peritoneal infection.
Academic Article Staphylococcus aureus synthesizes adenosine to escape host immune responses.
Academic Article IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge.
Academic Article Recurrent infections and immune evasion strategies of Staphylococcus aureus.
Academic Article Vaccine protection against Bacillus cereus-mediated respiratory anthrax-like disease in mice.
Academic Article Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria.
Academic Article The role of staphylothrombin-mediated fibrin deposition in catheter-related Staphylococcus aureus infections.
Academic Article Vaccine protection of leukopenic mice against Staphylococcus aureus bloodstream infection.
Academic Article Multiple ligands of von Willebrand factor-binding protein (vWbp) promote Staphylococcus aureus clot formation in human plasma.
Academic Article Protein A-neutralizing monoclonal antibody protects neonatal mice against Staphylococcus aureus.
Academic Article Role of protein A in the evasion of host adaptive immune responses by Staphylococcus aureus.
Academic Article Protein A suppresses immune responses during Staphylococcus aureus bloodstream infection in guinea pigs.
Academic Article Secretion of atypical protein substrates by the ESAT-6 secretion system of Staphylococcus aureus.
Academic Article Staphylococcus aureus degrades neutrophil extracellular traps to promote immune cell death.
Academic Article N-acetylglucosaminylation of serine-aspartate repeat proteins promotes Staphylococcus aureus bloodstream infection.
Academic Article Mouse models for infectious diseases caused by Staphylococcus aureus.
Academic Article The giant protein Ebh is a determinant of Staphylococcus aureus cell size and complement resistance.
Academic Article Genetic manipulation of Staphylococcus aureus.
Academic Article Adhesion of Staphylococcus aureus to the vessel wall under flow is mediated by von Willebrand factor-binding protein.
Academic Article Staphylococcal manipulation of host immune responses.
Academic Article Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing.
Academic Article Pathogenesis of Staphylococcus aureus Bloodstream Infections.
Academic Article Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion during Staphylococcus aureus infection.
Academic Article Contribution of Staphylococcus aureus Coagulases and Clumping Factor A to Abscess Formation in a Rabbit Model of Skin and Soft Tissue Infection.
Academic Article Staphylococcus aureus vaccines: Deviating from the carol.
Academic Article EssE Promotes Staphylococcus aureus ESS-Dependent Protein Secretion To Modify Host Immune Responses during Infection.
Academic Article EssD, a Nuclease Effector of the Staphylococcus aureus ESS Pathway.
Academic Article Staphylococcus aureus targets the purine salvage pathway to kill phagocytes.
Academic Article The transmembrane domain of the Staphylococcus aureus ESAT-6 component EssB mediates interaction with the integral membrane protein EsaA, facilitating partially regulated secretion in a heterologous host.
Academic Article Marginal role of von Willebrand factor-binding protein and coagulase in the initiation of endocarditis in rats with catheter-induced aortic vegetations.
Academic Article Staphylococcal Protein A Contributes to Persistent Colonization of Mice with Staphylococcus aureus.
Academic Article Staphylococcus aureus Decolonization of Mice With Monoclonal Antibody Neutralizing Protein A.
Academic Article Sortases, Surface Proteins, and Their Roles in Staphylococcus aureus Disease and Vaccine Development.
Academic Article Staphylococcus aureus TarP: A Brick in the Wall or Rosetta Stone?
Academic Article Extraction and Purification of Wall-Bound Polymers of Gram-Positive Bacteria.
Academic Article Staphylococcus aureus alpha-hemolysin impairs corneal epithelial wound healing and promotes intracellular bacterial invasion.
Academic Article Staphylococcus aureus endocarditis: distinct mechanisms of bacterial adhesion to damaged and inflamed heart valves.
Academic Article Staphylococcal Protein Secretion and Envelope Assembly.
Academic Article Rickettsia conorii O antigen is the target of bactericidal Weil-Felix antibodies.
Academic Article Staphylococcus aureus Exploits the Host Apoptotic Pathway To Persist during Infection.
Academic Article Rapid pathogen identification and antimicrobial susceptibility testing in in vitro endophthalmitis with matrix assisted laser desorption-ionization Time-of-Flight Mass Spectrometry and VITEK 2 without prior culture.
Academic Article Glycosylation-dependent opsonophagocytic activity of staphylococcal protein A antibodies.
Academic Article The Expression of von Willebrand Factor-Binding Protein Determines Joint-Invading Capacity of Staphylococcus aureus, a Core Mechanism of Septic Arthritis.
Academic Article Selective Host Cell Death by Staphylococcus aureus: A Strategy for Bacterial Persistence.
Academic Article A protein A based Staphylococcus aureus vaccine with improved safety.

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