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One or more keywords matched the following properties of Lebeau, Michelle M.
keywords Molecular analysis of genetic pathways leading to myeloid leukemias
keywords Development of mouse models for human leukemias
overview Dr. Le Beau’s research focuses on the molecular analysis of the recurring chromosomal abnormalities in human leukemias and lymphomas, correlating specific abnormalities with morphological and clinical features and the development of risk-adapted therapy. Ongoing projects include the molecular cloning of haploinsufficient myeloid leukemia-related genes involved in the del(5q) characteristic of therapy-related acute myeloid leukemia; development and characterization of murine models recapitulating the genetic mutations in acute myeloid leukemia and identification of secondary, cooperating mutations and genetic pathways to leukemogenesis; and the application of murine models for pre-clinical drug testing.
One or more keywords matched the following items that are connected to Lebeau, Michelle M.
Item TypeName
Concept Leukemia
Concept Leukemia, Megakaryoblastic, Acute
Concept Leukemia, Radiation-Induced
Concept Leukemia, Lymphocytic, Chronic, B-Cell
Concept Leukemia, Myeloid
Concept Leukemia, Myeloid, Acute
Concept Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Concept Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Concept Leukemia, Promyelocytic, Acute
Concept Leukemia-Lymphoma, Adult T-Cell
Concept Leukemia, Myeloid, Chronic-Phase
Concept Precursor Cell Lymphoblastic Leukemia-Lymphoma
Concept Myeloid-Lymphoid Leukemia Protein
Concept Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Academic Article Detection of DNA rearrangements in the AML1 and ETO loci and of an AML1/ETO fusion mRNA in patients with t(8;21) acute myeloid leukemia.
Academic Article Analysis of the t(6;11)(q27;q23) in leukemia shows a consistent breakpoint in AF6 in three patients and in the ML-2 cell line.
Academic Article International scoring system for evaluating prognosis in myelodysplastic syndromes.
Academic Article Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis.
Academic Article Myeloid leukemia after hematotoxins.
Academic Article Nineteen cases of the t(1;22)(p13;q13) acute megakaryblastic leukaemia of infants/children and a review of 39 cases: report from a t(1;22) study group.
Academic Article Molecular cloning of the breakpoints of a complex Philadelphia chromosome translocation: identification of a repeated region on chromosome 17.
Academic Article Gene expression profiles in acute myeloid leukemia with common translocations using SAGE.
Academic Article Establishment of cell lines from B-cell precursor acute lymphoblastic leukemia.
Academic Article Molecular analysis of a t(11;14)(q23;q11) from a patient with null-cell acute lymphoblastic leukemia.
Academic Article Acute myeloid leukaemia in a patient with Seckel syndrome.
Academic Article Prolonged subcutaneous administration of recombinant alpha 2b interferon in patients with previously untreated Philadelphia chromosome-positive chronic-phase chronic myelogenous leukemia: effect on remission duration and survival: Cancer and Leukemia Group B study 8583.
Academic Article Molecular characterization of 16p deletions associated with inversion 16 defines the critical fusion for leukemogenesis.
Academic Article Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells.
Academic Article Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.
Academic Article Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice identify cooperating events and genetic pathways to acute promyelocytic leukemia.
Academic Article Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice parallel human acute promyelocytic leukemia.
Academic Article Der(16)T(1-16) is a nonrandom secondary chromosome aberration in many types of human neoplasia, including myxoid liposarcoma, rhabdomyosarcoma and Philadelphia-chromosome-positive acute lymphoblastic-leukemia.
Academic Article The spectrum of somatic mutations in high-risk acute myeloid leukaemia with -7/del(7q).
Academic Article Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.
Academic Article Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice.
Academic Article MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.
Academic Article Overexpression and knockout of miR-126 both promote leukemogenesis.
Academic Article Haploinsufficient loss of multiple 5q genes may fine-tune Wnt signaling in del(5q) therapy-related myeloid neoplasms.
Academic Article Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia.
Academic Article miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia.
Academic Article The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.
Academic Article Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.
Academic Article Eradication of Acute Myeloid Leukemia with FLT3 Ligand-Targeted miR-150 Nanoparticles.
Academic Article Diagnostic evaluation of RNA sequencing for the detection of genetic abnormalities associated with Ph-like acute lymphoblastic leukemia (ALL).
Academic Article Therapy-related myeloid neoplasms: when genetics and environment collide.
Academic Article DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.
Academic Article KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.
Academic Article Dissecting the role of aberrant DNA methylation in human leukaemia.
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  • Leukemia