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Search Results to Sara Szuchet

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One or more keywords matched the following properties of Szuchet, Sara

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keywords Demyelinating Diseases
keywords neuro degenerative diseases
overview The long-term goal of my laboratory is to decipher the etiology and pathogenesis of multiple sclerosis (MS) – a CNS demyelinating and neurodegenerative disease that cripples the young and bright. With the firm belief that in order to decrypt the breakdown of myelin in MS, we have to understand how it is formed, our current efforts are centered on two major projects. One, defining the molecular mechanism of myelin sheath formation by following the synthesis of myelin membranes (MyMs), their packaging into myelinophore organelles (MFOs) and transportation along an oligodendrocyte process using live imaging of embryonic avian optic nerve at different stages of development; purifying and characterizing the contents of MFOs. Two, testing the hypothesis that ectosomes are the conveyors of signals that coordinate and orchestrate the modular structure of the myelinated axon. We are developing technologies to obtain pure cell-specific ectosomes by molecularly color-code them. We are also customizing a microfluidic platform suitable to integrate multiple processes in a single lab-on-a-chip format. We plan to establish unique EM grid compatible bi-chamber for OLG-neuron cultures and capture the formation of cell-specific ectosomes using correlative light and electron microscopy and phase contrast cryo-electron tomography. We will assemble tomograms of the initial OLG-neuron encounter so that we can structurally model the interface in a 3D space.

One or more keywords matched the following items that are connected to Szuchet, Sara

Item TypeName
Concept Brain Diseases
Concept Autoimmune Diseases
Concept Mice, Neurologic Mutants
Concept Neurons
Concept Cell Adhesion Molecules, Neuronal
Concept Neuroglia
Concept Neuromuscular Depolarizing Agents
Academic Article Myelination by mature ovine oligodendrocytes in vivo and in vitro: evidence that different steps in the myelination process are independently controlled.
Academic Article Oligodendrocyte proteoglycans: modulation by cell-substratum adhesion.
Academic Article Differential expression of the heavy-chain ferritin gene in non-adhered and adhered oligodendrocytes.
Academic Article Differentiation/regeneration of oligodendrocytes entails the assembly of a cell-associated matrix.
Academic Article Reactive astrocytes upregulate one or more gene products that are recognized by monoclonal antibody H.
Academic Article NOVOcan: a molecular link among selected glial cells.
Academic Article Intracellular messengers. Influence of oligodendrocyte substratum adhesion.
Academic Article Mature oligodendrocytes cultured in the absence of neurons recapitulate the ontogenic development of myelin membranes.
Academic Article Expression and modulation of K+ currents in oligodendrocytes: possible role in myelinogenesis.
Academic Article The genetic signature of perineuronal oligodendrocytes reveals their unique phenotype.
Academic Article Voltage-gated potassium currents in cultured ovine oligodendrocytes.
Academic Article Forskolin and phorbol esters decrease the same K+ conductance in cultured oligodendrocytes.
Academic Article Lipid and glycolipid metabolism of cultured astrocytes: a time course study.
Academic Article Cultured oligodendrocytes. A role for cell-substratum interaction in phenotypic expression.
Academic Article Maintenance of isolated oligodendrocytes in long-term culture.
Academic Article Cell-cell interactions of isolated and cultured oligodendrocytes: formation of linear occluding junctions and expression of peculiar intramembrane particles.
Academic Article Oligodendrocyte adhesion activates protein kinase C-mediated phosphorylation of myelin basic protein.
Academic Article Separation of ovine oligodendrocytes into two distinct bands on a linear sucrose gradient.
Academic Article Plasma membrane of cultured oligodendrocytes: III. Relatedness to myelin.
Academic Article Signal transduction pathways in oligodendrocytes: role of tumor necrosis factor-alpha.
Academic Article Detection of visna virus antigens and RNA in glial cells in foci of demyelination.
Academic Article Myelin palingenesis. 2. Immunocytochemical localization of myelin/oligodendrocyte glycolipids in multilamellar structures.
Academic Article Lipid metabolism of isolated oligodendrocytes maintained in long-term culture mimics events associated with myelinogenesis.
Academic Article An in-vitro approach to the study of oligodendrocytes and their involvement in multiple sclerosis.
Academic Article A monoclonal antibody against human T suppressor lymphocytes binds specifically to the surface of cultured oligodendrocytes.
Academic Article Characterization of a subset of oligodendrocytes separated on the basis of selective adherence properties.
Academic Article Synthesis of myelin glycosphingolipids by isolated oligodendrocytes in tissue culture.
Academic Article Oligodendrocyte-substratum adhesion activates the synthesis of specific lipid species involved in cell signaling.
Academic Article Synthesis of gangliosides by cultured oligodendrocytes.
Academic Article Ultrastructural changes accompanying the growth of isolated oligodendrocytes.
Academic Article Depolarizing agents and tumor necrosis factor-alpha modulate protein phosphorylation in oligodendrocytes.
Academic Article Oligodendrocyte substratum adhesion modulates expression of adenylate cyclase-linked receptors.
Academic Article Plasma membrane of cultured oligodendrocytes: I. Isolation, purification, and initial characterization.
Academic Article Plasma membrane of cultured oligodendrocytes: II. Possible structural and functional domains.
Academic Article A monoclonal antibody that binds to both astrocytes and myelin sheaths.
Academic Article GRASP: a novel heparin-binding serum glycoprotein that mediates oligodendrocyte-substratum adhesion.
Academic Article Myelin palingenesis. 1. Electron microscopical localization of myelin/oligodendrocyte proteins in multilamellar structures by the immunogold method.
Academic Article A peanut agglutinin binding glycoprotein in CNS myelin and oligodendrocytes.

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  • degenerative
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