The University of Chicago Header Logo

Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following properties of Nagler, Cathryn R.
keywords Microbiome, Food Allergy, Tolerance
overview The Nagler Lab studies the mechanisms governing tolerance to dietary antigens. They were one of the first to identify a link between resident intestinal bacteria and the regulation of mucosal immunity. During the last fifteen years, their work has focused on examining how commensal bacteria regulate susceptibility to allergic responses to food. They have proposed that the striking generational increase in food allergies can be explained, in part, by alterations in the composition and function of the commensal microbiome. In support of this hypothesis, Nagler Lab described a role for a particular population of mucosa-associated commensal bacteria in protection from allergic sensitization in mice. Initial translational studies showed that the composition of the fecal microbiota is altered in infants with cow’s milk allergy. To understand how the microbiota regulates allergic disease in humans they have colonized germ free mice with human bacteria from the feces of healthy or cow’s milk allergic (CMA) infants. The group discovered that mice colonized with CMA infants’ microbiota exhibited an anaphylactic response to the cow’s milk allergen b-lactoglobulin, while mice colonized with healthy infants’ microbiota were protected against an allergic response. They defined a microbiota signature that distinguishes the CMA and healthy populations in both the human donors and the colonized mice. Analysis of gene expression in ileal intestinal epithelial cells of colonized mice identified a significant correlation between the genes associated with allergy protection and taxa from the Lachnospiraceae family, supporting a causal role for specific bacterial species in protection against food allergy. These robust, pre-clinical, gnotobiotic models are an ideal system to identify key host-microbial interactions that contribute to allergic sensitization to food. With support from the Polsky Center for Entrepreneurship and Innovation, Nagler Lab has created a start-up company, ClostraBio, to develop novel microbiome-modulating therapeutics to prevent or treat food allergy.
One or more keywords matched the following items that are connected to Nagler, Cathryn R.
Item TypeName
Academic Article Regional mucosa-associated microbiota determine physiological expression of TLR2 and TLR4 in murine colon.
Academic Article Commensal bacteria protect against food allergen sensitization.
Academic Article Health: The weighty costs of non-caloric sweeteners.
Academic Article Cellular and molecular pathways through which commensal bacteria modulate sensitization to dietary antigens.
Academic Article Our interface with the built environment: immunity and the indoor microbiota.
Academic Article Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis.
Academic Article The role of the commensal microbiota in the regulation of tolerance to dietary allergens.
Academic Article Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants.
Academic Article The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease.
Academic Article What's LPS Got to Do with It? A Role for Gut LPS Variants in Driving Autoimmune and Allergic Disease.
Academic Article The composition of the microbiota modulates allograft rejection.
Academic Article Rapid and Efficient Generation of Regulatory T Cells to Commensal Antigens in the Periphery.
Academic Article Cutting Edge: Lymphotoxin Signaling Is Essential for Clearance of Salmonella from the Gut Lumen and Generation of Anti-Salmonella Protective Immunity.
Academic Article The Influence of the Microbiome on Allergic Sensitization to Food.
Academic Article Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens.
Academic Article Healthy infants harbor intestinal bacteria that protect against food allergy.
Academic Article Influences on allergic mechanisms through gut, lung, and skin microbiome exposures.
Academic Article The Microbiome and Food Allergy.
Academic Article B cell superantigens in the human intestinal microbiota.
Academic Article Drugging the microbiome.
Academic Article B cells and the microbiota: a missing connection in food allergy.
Academic Article Fecal microbiome and metabolome differ in healthy and food-allergic twins.
Academic Article Engineered yeast tune down gut inflammation.
Academic Article Fe, fi, fo, fum, I smell the diet of a healthy human.
Academic Article Modern World Influences on the Microbiome and Their Consequences for Immune-Mediated Disease.
Academic Article Host-Microbiota Interactions in the Esophagus During Homeostasis and Allergic Inflammation.
Concept Gastrointestinal Microbiome
Concept Fecal Microbiota Transplantation
Concept Microbiota
Academic Article A Lipopolysaccharide-Enriched Cow's Milk Allergy Microbiome Promotes a TLR4-Dependent Proinflammatory Intestinal Immune Response.
Search Criteria
  • Microbiome