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Search Results to S. Murray Sherman

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overview The research in the laboratory is directed at issues of thalamic functional organization and thalamocortical relationships, mainly using the visual and somatosensory pathways in the mouse as experimental models. We use a broad interdisciplinary approach, attempting to answer the same or closely related questions with several different techniques. More specifically, we use neuroanatomical techniques to explore various circuits; we use in vitro recordings from brain slices to study cell and synaptic properties; and we record from in vivo preparations to evaluate these circuits in whole animals using an awake, behaving preparation to determine the relationship between behavioral and cognitive parameters and thalamocortical functioning. Stimulation techniques in slices include electrical activation and laser photostimulation involving both uncaging of glutamate (or GABA) and optogenetics; recording involves mainly patching of single neurons and imaging via flavoprotein autofluorescence. For in vivo recording, we use conventional single cell electrophysiology, current source density analysis, and have recently imported the technique of 2-photon calcium imaging, which enables us to follow responses of hundreds of cortical cells simultaneously. To activate or inhibit specific pathways we use optogenetics and DREAD (Designer Receptors Exclusively Activated by Designer Drugs) techniques often involving specific mouse genetic lines (e.g., involving Cre expression in transgenic mouse lines)

One or more keywords matched the following items that are connected to Sherman, S. Murray

Item TypeName
Concept Electrophysiology
Academic Article Mapping of the functional interconnections between thalamic reticular neurons using photostimulation.
Academic Article Differences in response to serotonergic activation between first and higher order thalamic nuclei.
Academic Article Differences in response to muscarinic activation between first and higher order thalamic relays.
Grant Control of the Visual relay Through LGN
Academic Article Latency variability of responses to visual stimuli in cells of the cat's lateral geniculate nucleus.
Academic Article The effects of saccadic eye movements on the activity of geniculate relay neurons in the monkey.
Academic Article Behavioral, electrophysiological and morphological studies of binocular competition in the development of the geniculo-cortical pathways of cats.
Academic Article Effects of early monocular deprivation on visual input to cat superior colliculus.
Academic Article The brain-stem parabrachial region controls mode of response to visual stimulation of neurons in the cat's lateral geniculate nucleus.
Academic Article Behavioral studies of binocular competition in cats.
Academic Article Response latencies of cells in the cat's lateral geniculate nucleus are less variable during burst than tonic firing.
Academic Article Effects of early monocular lid suture upon neurons in the cat's medial interlaminar nucleus.
Academic Article An effect of early monocular lid suture upon the development of X-cells in the cat's lateral geniculate nucleus.
Academic Article Glutamate inhibits thalamic reticular neurons.
Academic Article Effects of membrane voltage on receptive field properties of lateral geniculate neurons in the cat: contributions of the low-threshold Ca2+ conductance.
Academic Article Cellular mechanisms underlying activity patterns in the monkey thalamus during visual behavior.
Academic Article Morphology and physiology of single neurons in the medial interlaminar nucleus of the cat's lateral geniculate nucleus.
Academic Article In vivo recording of postsynaptic potentials and low threshold spikes in W cells of the cat's lateral geniculate nucleus.
Academic Article Dendritic depolarization efficiently attenuates low-threshold calcium spikes in thalamic relay cells.
Academic Article Synaptic circuitry of physiologically identified W-cells in the cat's dorsal lateral geniculate nucleus.
Academic Article Effects of early binocular deprivation on visual input to cat superior colliculus.
Academic Article Metabotropic glutamate receptors switch visual response mode of lateral geniculate nucleus cells from burst to tonic.
Academic Article Behavioral and morphological evidence for binocular competition in the postnatal development of the dog's visual system.
Academic Article Studies of the cat's medial interlaminar nucleus: a subdivision of the dorsal lateral geniculate nucleus.
Academic Article Morphology of functionally identified neurons in lateral geniculate nucleus of the cat.
Academic Article Fine structural morphology of identified X- and Y-cells in the cat's lateral geniculate nucleus.
Academic Article Effects of visual cortex lesions upon the visual fields of monocularly deprived cats.
Academic Article Encoding of visual information by LGN bursts.
Academic Article Morphology and axonal projection patterns of individual neurons in the cat perigeniculate nucleus.

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  • Behavioral
  • Electrophysiology