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Search Results to S. Murray Sherman

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One or more keywords matched the following properties of Sherman, S.

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overview The research in the laboratory is directed at issues of thalamic functional organization and thalamocortical relationships, mainly using the visual and somatosensory pathways in the mouse as experimental models. We use a broad interdisciplinary approach, attempting to answer the same or closely related questions with several different techniques. More specifically, we use neuroanatomical techniques to explore various circuits; we use in vitro recordings from brain slices to study cell and synaptic properties; and we record from in vivo preparations to evaluate these circuits in whole animals using an awake, behaving preparation to determine the relationship between behavioral and cognitive parameters and thalamocortical functioning. Stimulation techniques in slices include electrical activation and laser photostimulation involving both uncaging of glutamate (or GABA) and optogenetics; recording involves mainly patching of single neurons and imaging via flavoprotein autofluorescence. For in vivo recording, we use conventional single cell electrophysiology, current source density analysis, and have recently imported the technique of 2-photon calcium imaging, which enables us to follow responses of hundreds of cortical cells simultaneously. To activate or inhibit specific pathways we use optogenetics and DREAD (Designer Receptors Exclusively Activated by Designer Drugs) techniques often involving specific mouse genetic lines (e.g., involving Cre expression in transgenic mouse lines)

One or more keywords matched the following items that are connected to Sherman, S.

Item TypeName
Concept Glutamic Acid
Concept Receptors, Metabotropic Glutamate
Concept Receptors, Ionotropic Glutamate
Academic Article Mapping of the functional interconnections between thalamic reticular neurons using photostimulation.
Academic Article Synaptic properties of thalamic input to the subgranular layers of primary somatosensory and auditory cortices in the mouse.
Academic Article Synaptic properties of corticocortical connections between the primary and secondary visual cortical areas in the mouse.
Academic Article Synaptic properties of connections between the primary and secondary auditory cortices in mice.
Academic Article In vitro imaging using laser photostimulation with flavoprotein autofluorescence.
Academic Article Functional significance of synaptic terminal size in glutamatergic sensory pathways in thalamus and cortex.
Academic Article Glutamatergic inhibition in sensory neocortex.
Academic Article Activation requirements for metabotropic glutamate receptors.
Academic Article Modulatory effects of metabotropic glutamate receptors on local cortical circuits.
Academic Article Thalamocortical interactions.
Academic Article Activation of both Group I and Group II metabotropic glutamatergic receptors suppress retinogeniculate transmission.
Academic Article A modulatory effect of the feedback from higher visual areas to V1 in the mouse.
Academic Article The function of metabotropic glutamate receptors in thalamus and cortex.
Academic Article Modulatory effects of activation of metabotropic glutamate receptors on GABAergic circuits in the mouse cortex.
Academic Article Modulatory effects of activation of metabotropic glutamate receptors on GABAergic circuits in the mouse thalamus.
Academic Article Thalamus plays a central role in ongoing cortical functioning.
Grant Effects of Visual Deprivation on the Visual System
Grant FUNCTIONAL ULTRASTRUCTURE OF CENTRAL VISUAL PATHWAYS
Academic Article Intrinsic modulators of auditory thalamocortical transmission.
Academic Article Glutamate inhibits thalamic reticular neurons.
Academic Article Glutamate locally activates dendritic outputs of thalamic interneurons.
Academic Article Dendritic depolarization efficiently attenuates low-threshold calcium spikes in thalamic relay cells.
Academic Article Ultrastructural localization suggests that retinal and cortical inputs access different metabotropic glutamate receptors in the lateral geniculate nucleus.
Academic Article Metabotropic glutamate receptors switch visual response mode of lateral geniculate nucleus cells from burst to tonic.
Academic Article Control of dendritic outputs of inhibitory interneurons in the lateral geniculate nucleus.

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  • Glutamate