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Search Results to Edwin L. Ferguson

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One or more keywords matched the following properties of Ferguson, Edwin

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keywords Drosophila
overview The lab approaches questions of pattern formation and cell fate specification in the fruit fly Drosophila melanogaster. Our current interests are the mechanisms underlying the patterning of the embryonic dorsal-ventral (D/V) axis and the asymmetric self-renewal divisions of adult stem cells. The main focus of lab has been on the role of the Bone Morphogenetic Protein (BMP) family member Decapentaplegic (Dpp) in patterning the D/V axis. Over the years, my laboratory discovered the conservation of dorsal-ventral patterning mechanisms between arthropods and chordates, identified the function of the Spemann organizer in Xenopus, showed that a non-linear feedback circuit resulted in a bistable pattern of BMP signaling during Drosophila D/V patterning, identified a genetic network that confers robustness to the D/V patterning system in Drosophila, and was involved in a collaboration to demonstrate that spatial-temporal changes in the BMP gradient drove morphological changes during Dipteran evolution. We have also investigated the processes responsible for the maintenance of the germ line stem cells (GSCs) in the adult ovary. The GSCs are present in a niche composed of non-dividing somatic cells, and these cells secrete BMP ligands necessary for GSC maintenance. The GSC has high levels of BMP signaling, while its sister cell, the Cystoblast, has low levels of BMP signaling and begins the process of differentiation. We have identified multiple redundant mechanisms that aid in creating this dichotomy in BMP signaling between sister cells. In particular, we have shown that interactions between the GSC and the surrounding niche cells create an intrinsic polarity in the GSC that both controls the plane of GSC division and elevates responsiveness to Dpp within the GSC. Recently, we have shown that GSCs can be maintained in the niche with very low levels of BMP signaling, which has implications for stem cell maintenance during aging.

One or more keywords matched the following items that are connected to Ferguson, Edwin

Item TypeName
Concept Drosophila melanogaster
Concept Drosophila Proteins
Academic Article The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor.
Academic Article Conservation of dorsal-ventral patterning in arthropods and chordates.
Academic Article Morphogen gradients: new insights from DPP.
Academic Article Spatially restricted activation of the SAX receptor by SCW modulates DPP/TKV signaling in Drosophila dorsal-ventral patterning.
Academic Article The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4.
Academic Article The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis.
Academic Article Germline stem cell number in the Drosophila ovary is regulated by redundant mechanisms that control Dpp signaling.
Academic Article Spatial bistability of Dpp-receptor interactions during Drosophila dorsal-ventral patterning.
Academic Article SMAD signaling drives heart and muscle dysfunction in a Drosophila model of muscular dystrophy.
Academic Article Niche-associated activation of rac promotes the asymmetric division of Drosophila female germline stem cells.
Academic Article Fish are like flies are like frogs: conservation of dorsal-ventral patterning mechanisms.
Academic Article A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin.
Academic Article A positive role for Short gastrulation in modulating BMP signaling during dorsoventral patterning in the Drosophila embryo.
Academic Article zen and the art of phenotypic maintenance: canalization of embryonic dorsal-ventral patterning in Drosophila.
Academic Article A genetic network conferring canalization to a bistable patterning system in Drosophila.
Academic Article Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm.
Academic Article Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo.
Academic Article Localized enhancement and repression of the activity of the TGF-beta family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo.
Academic Article Extracellular morphogens in Drosophila embryonic dorsal-ventral patterning.
Academic Article The Drosophila dorsal-ventral patterning gene tolloid is related to human bone morphogenetic protein 1.
Academic Article Dorsal-ventral pattern formation in the Drosophila embryo: the role of zygotically active genes.

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