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Search Results to Richard Kraig

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keywords migraine, enrichment, green exercise, exosomes, IGF-1, multiple sclerosis, trauma
overview Dr. Richard Kraig is an expert in migraine patient care, migraine research and cerebrovascular disease research. His clinical interests focus on the diagnosis and treatment of migraine headaches. He oversees the Cerebrovascular Disease and Aging Laboratories, which focus on migraine, stroke, epilepsy and cognitive decline from aging. An active researcher, Dr. Kraig leads investigations to determine how physical, mental and social activities can lessen the impact of neurological disease. Examination of such mechanisms by which the brain naturally protects itself may lead to more selective cellular and molecular targets, as well as new therapeutic strategies against brain disease. Dr. Kraig's research helps him to develop individualized treatment plans for patients in the Migraine Headache Clinic. He is also involved in teaching medical students, graduate students and residents.

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Item TypeName
Concept Actins
Concept Action Potentials
Concept Adrenergic alpha-Agonists
Concept Amygdala
Concept Acetazolamide
Concept Cyclic AMP
Concept Acid-Base Equilibrium
Concept Acidosis
Concept Aging
Concept Adenosine Triphosphate
Concept Administration, Intranasal
Concept Antigens, Differentiation
Concept Cats
Concept Cell Membrane Permeability
Concept Cerebral Cortex
Concept Anesthetics, Local
Concept Chlorides
Concept Analysis of Variance
Concept Antibody Specificity
Concept B-Lymphocytes
Concept Cell Count
Concept Cell Movement
Concept Cerebral Infarction
Concept Cerebrovascular Circulation
Concept Dimethadione
Concept Brain Injuries
Concept Autoradiography
Concept Chemistry Techniques, Analytical
Concept Carbonic Acid
Concept Biophysics
Concept Barium
Concept Bicarbonates
Concept Brain
Concept Brain Chemistry
Concept Capillary Permeability
Concept Cell Division
Concept Carbonates
Concept Central Nervous System
Concept Cerebellum
Concept Capillaries
Concept Blood-Brain Barrier
Concept Cold Temperature
Concept Caffeine
Concept Cholesterol
Concept Electric Fish
Concept Electrophysiology
Concept Cholelithiasis
Concept Depression
Concept Fishes
Concept Motor Cortex
Concept Frontal Lobe
Concept Hippocampus
Concept Hydrogen Peroxide
Concept Insulin-Like Growth Factor I
Concept Enzyme-Linked Immunosorbent Assay
Concept Endotoxins
Concept Housing, Animal
Concept Flow Cytometry
Concept Leukocytes
Concept Phenylephrine
Concept Mammals
Concept Potassium Chloride
Concept Protein Denaturation
Concept Immunohistochemistry
Concept Necrosis
Concept Mice, Inbred C57BL
Concept Migraine Disorders
Concept Rats, Inbred SHR
Concept Synaptic Transmission
Concept Lipopolysaccharides
Concept Meninges
Concept Parietal Lobe
Concept Phosphorylation
Concept Nitroprusside
Concept Oxygen
Concept Trigeminal Nuclei
Concept Immunoglobulin G
Concept Rats, Inbred F344
Concept Regional Blood Flow
Concept Rats, Inbred WKY
Concept Humans
Concept Fura-2
Concept Styrenes
Concept Synapses
Concept Intracellular Membranes
Concept United States
Concept Vasoconstriction
Concept Tumor Necrosis Factor-alpha
Concept Trigeminal Caudal Nucleus
Concept Calcium Channels
Concept Dinoprostone
Concept Receptors, Prostaglandin E
Concept Up-Regulation
Concept Ion Channel Gating
Concept Mitochondria
Concept Multiple Sclerosis
Concept Second Messenger Systems
Concept Interleukin-10
Concept Proto-Oncogene Proteins c-fos
Concept Eicosanoids
Concept Rats, Sprague-Dawley
Concept Rats, Wistar
Concept Pyramidal Cells
Concept Myelin Sheath
Concept National Institutes of Health (U.S.)
Concept Cyclooxygenase Inhibitors
Concept Apoptosis
Concept Entorhinal Cortex
Concept Cyclooxygenase 2 Inhibitors
Concept Calcium Channels, P-Type
Concept Calcium Signaling
Concept Excitatory Amino Acid Agonists
Concept rab GTP-Binding Proteins
Concept 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
Concept Serum
Concept Receptors, Tumor Necrosis Factor, Type I
Concept Green Fluorescent Proteins
Concept Chloride Channels
Concept Paracrine Communication
Concept Ectodysplasins
Concept Interleukin-1beta
Concept Migraine with Aura
Concept Portacaval Shunt, Surgical
Concept Mice
Concept Endosomes
Concept Rats, Inbred Strains
Concept Sodium Chloride
Concept Translational Medical Research
Concept Rats
Concept Temperature
Concept Blotting, Western
Concept Lysosomal-Associated Membrane Protein 1
Concept Blotting, Northern
Concept Interleukin-11
Concept N-Methylaspartate
Concept Dentate Gyrus
Concept Calcium Channels, Q-Type
Concept CA1 Region, Hippocampal
Concept Neocortex
Concept Cell Size
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Concept Exosomes
Concept Antibodies
Concept Axons
Concept Benzylidene Compounds
Concept Brain Neoplasms
Concept Calcium
Concept Calcium Channel Blockers
Concept Cerebellar Nuclei
Concept Cerebral Arteries
Concept Brain Ischemia
Concept Hypothalamus
Concept Kinetics
Concept Lysine
Concept Membrane Potentials
Concept Seizures
Concept Somatosensory Cortex
Concept T-Lymphocytes
Concept Vasodilation
Concept Signal Transduction
Concept Gelsolin
Concept Potassium Channels, Voltage-Gated
Concept MicroRNAs
Concept Biophysical Phenomena
Concept CA3 Region, Hippocampal
Academic Article Long-term elevation of cyclooxygenase-2, but not lipoxygenase, in regions synaptically distant from spreading depression.
Academic Article Neocortical spreading depression provokes the expression of c-fos protein-like immunoreactivity within trigeminal nucleus caudalis via trigeminovascular mechanisms.
Academic Article Whole-cell chloride currents in rat astrocytes accompany changes in cell morphology.
Academic Article Eicosanoids and nitric oxide influence induction of reactive gliosis from spreading depression in microglia but not astrocytes.
Academic Article Cytoskeletal actin gates a Cl- channel in neocortical astrocytes.
Academic Article Comment on Ingvardsen et al., PAIN, 72 (1997) 407-415.
Academic Article Reactive astrocytosis from excitotoxic injury in hippocampal organ culture parallels that seen in vivo.
Academic Article Astroglial acid-base dynamics in hyperglycemic and normoglycemic global ischemia.
Academic Article Prostaglandin E receptor subtypes in cultured rat microglia and their role in reducing lipopolysaccharide-induced interleukin-1beta production.
Academic Article Neuronal nitric oxide synthase expression is induced in neocortical astrocytes after spreading depression.
Academic Article Calcium waves precede electrophysiological changes of spreading depression in hippocampal organ cultures.
Academic Article Astrocytic clasmatodendrosis in hippocampal organ culture.
Academic Article Prostaglandin E2 and 4-aminopyridine prevent the lipopolysaccharide-induced outwardly rectifying potassium current and interleukin-1beta production in cultured rat microglia.
Academic Article Carbonic acid buffer species measured in real time with an intracellular microelectrode array.
Academic Article Hippocampal spreading depression bilaterally activates the caudal trigeminal nucleus in rodents.
Academic Article Intracellular pH rises and astrocytes swell after portacaval anastomosis in rats.
Academic Article Spreading depression increases immunohistochemical staining of glial fibrillary acidic protein.
Academic Article Homeostatic plasticity in hippocampal slice cultures involves changes in voltage-gated Na+ channel expression.
Academic Article P/Q Ca2+ channel blockade stops spreading depression and related pyramidal neuronal Ca2+ rise in hippocampal organ culture.
Academic Article Optimization of multiplexed bead-based cytokine immunoassays for rat serum and brain tissue.
Academic Article Optical current source density analysis in hippocampal organotypic culture shows that spreading depression occurs with uniquely reversing currents.
Academic Article Ionic concomitants of astroglial transformation to reactive species.
Academic Article Astrocytic acidosis in hyperglycemic and complete ischemia.
Academic Article Multiplexed cytokine protein expression profiles from spreading depression in hippocampal organotypic cultures.
Academic Article Cold pre-conditioning neuroprotection depends on TNF-a and is enhanced by blockade of interleukin-11.
Academic Article Modeling neural immune signaling of episodic and chronic migraine using spreading depression in vitro.
Academic Article Spreading depression sends microglia on Lévy flights.
Academic Article Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma.
Academic Article Differential effects of low-dose endotoxin on the cerebral circulation during pregnancy.
Academic Article Compartmentation of acid-base balance in brain during complete ischemia.
Academic Article Sodium liquid ion exchanger microelectrode used to measure large extracellular sodium transients.
Academic Article Carbonic acid buffer changes during complete brain ischemia.
Academic Article TNF-a and Microglial Hormetic Involvement in Neurological Health & Migraine.
Academic Article Astroglial H+ and Ca2+ changes--signals for cell activation?
Academic Article Insulin-like growth factor-1 lowers spreading depression susceptibility and reduces oxidative stress.
Academic Article Hydrogen ion buffering during complete brain ischemia.
Academic Article Acid-induced injury in elasmobranch brain.
Academic Article Astrocyte precursor response to embryonic brain injury.
Academic Article Bicarbonate and ammonia changes in brain during spreading depression.
Academic Article Acid-induced changes of brain protein buffering.
Academic Article Hydrogen ions kill brain at concentrations reached in ischemia.
Academic Article The effects of extracellular acidosis on neurons and glia in vitro.
Academic Article Isotopic dilution analysis. Cholesterol in gallstones and caffein in tea, cola, and NoDoz.
Academic Article Characterization of inducible cyclooxygenase in rat brain.
Academic Article Potassium, calcium, chloride and sodium changes in extracellular space during spreading depression in cerebellum [proceedings].
Academic Article Heterogeneous distribution of hydrogen and bicarbonate ions during complete brain ischemia.
Academic Article Chloride and potassium changes measured during spreading depression in catfish cerebellum.
Academic Article Monomeric IgG is neuroprotective via enhancing microglial recycling endocytosis and TNF-alpha.
Academic Article Alkaline and acid transients in cerebellar microenvironment.
Academic Article Light and electron microscopic evaluation of hydrogen ion-induced brain necrosis.
Academic Article Intracellular pH of astrocytes increases rapidly with cortical stimulation.
Academic Article In vivo measurement of regional brain and tumor pH using [14C]dimethyloxazolidinedione and quantitative autoradiography. II: Characterization of the extracellular fluid compartment using pH-sensitive microelectrodes and [14C]sucrose.
Academic Article Extracellular ionic variations during spreading depression.
Academic Article Focal elevations in neocortical interstitial K+ produced by stimulation of the fastigial nucleus in rat.
Academic Article Dynamics of interstitial and intracellular pH in evolving brain infarct.
Academic Article Intracellular pH transients of mammalian astrocytes.
Academic Article Determination of extracellular bicarbonate and carbon dioxide concentrations in brain slices using carbonate and pH-selective microelectrodes.
Academic Article Insulin-like growth factor-1 abrogates microglial oxidative stress and TNF-a responses to spreading depression.
Academic Article IFN?-stimulated dendritic cell exosomes as a potential therapeutic for remyelination.
Academic Article Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination.
Academic Article What are exosomes and how can they be used in multiple sclerosis therapy?
Academic Article Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment.
Academic Article Phasic Treatment with Interferon Gamma Stimulates Release of Exosomes that Protect Against Spreading Depression.
Academic Article Environmental Enrichment Stimulates Immune Cell Secretion of Exosomes that Promote CNS Myelination and May Regulate Inflammation.
Academic Article Seizures in Women with Preeclampsia: Mechanisms and Management.
Academic Article NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface.
Academic Article Intranasally administered IGF-1 inhibits spreading depression in vivo.
Academic Article IFN?-Stimulated Dendritic Cell Exosomes for Treatment of Migraine Modeled Using Spreading Depression.
Academic Article Insulin-like growth factor-1 inhibits spreading depression-induced trigeminal calcitonin gene related peptide, oxidative stress & neuronal activation in rat.

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