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Rebay, Ilaria
One or more keywords matched the following properties of Rebay, Ilaria
PropertyValue
keywords Retinal Development
overview The long-term goal of research in the Rebay Lab is to understand how signaling networks, cytoskeletal dynamics and tissue geometry work together to direct specific developmental decisions and programs. We use the developing Drosophila eye and heart as tractable model systems in which to explore how cell fates are specified and organized into functional tissues and organs. Our experimental approach is multidisciplinary, and incorporates molecular genetics, genomics, quantitative imaging, biochemistry and mathematical modeling. Current projects are focused on transcriptional networks and cellular mechanisms that regulate and stabilize the transition from uncommitted progenitor to specified fate and on signaling mechanisms and tissue-level biomechanical properties that together drive terminal differentiation and morphogenesis.
One or more keywords matched the following items that are connected to Rebay, Ilaria
Item TypeName
Concept Gene Expression Regulation, Developmental
Concept Embryonic Development
Concept Developmental Biology
Academic Article Signal transduction downstream from Ras in Drosophila.
Academic Article split ends, a new component of the Drosophila EGF receptor pathway, regulates development of midline glial cells.
Academic Article Eyes absent mediates cross-talk between retinal determination genes and the receptor tyrosine kinase signaling pathway.
Academic Article CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE.
Academic Article Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network.
Academic Article The novel plant homeodomain protein rhinoceros antagonizes Ras signaling in the Drosophila eye.
Academic Article Splits ends is a tissue/promoter specific regulator of Wingless signaling.
Academic Article MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN.
Academic Article Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function.
Academic Article Signaling circuitries in development: insights from the retinal determination gene network.
Academic Article Intersection of signal transduction pathways and development.
Academic Article Targeting Drosophila eye development.
Academic Article Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm.
Academic Article Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk.
Academic Article Sterile alpha motif domain-mediated self-association plays an essential role in modulating the activity of the Drosophila ETS family transcriptional repressor Yan.
Academic Article Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives.
Academic Article Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development.
Academic Article Characterization of the split ends-like gene spenito reveals functional antagonism between SPOC family members during Drosophila eye development.
Academic Article Ras signal transduction pathway in Drosophila eye development.
Academic Article The eyes absent family of phosphotyrosine phosphatases: properties and roles in developmental regulation of transcription.
Academic Article The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway.
Academic Article Analysis of phenotypic abnormalities and cell fate changes caused by dominant activated and dominant negative forms of the Notch receptor in Drosophila development.
Academic Article Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway.
Academic Article Signal integration during development: insights from the Drosophila eye.
Academic Article Function of the ETS transcription factor Yan in border cell migration.
Academic Article The Abelson tyrosine kinase regulates Notch endocytosis and signaling to maintain neuronal cell fate in Drosophila photoreceptors.
Academic Article Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers.
Academic Article 3D chromatin interactions organize Yan chromatin occupancy and repression at the even-skipped locus.
Academic Article Long-range integration of repressive and patterning inputs.
Academic Article Multiple Functions of the Eya Phosphotyrosine Phosphatase.
Academic Article Retinal Axon Guidance Requires Integration of Eya and the Jak/Stat Pathway into Phosphotyrosine-Based Signaling Circuitries in Drosophila.
Academic Article Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks.
Academic Article Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in the Drosophila retina.
Award or Honor Receipt J. and J. Neubauer Faculty Development Fellowship
Academic Article Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification.
Academic Article Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila.
Academic Article A context-dependent bifurcation in the Pointed transcriptional effector network contributes specificity and robustness to retinal cell fate acquisition.
Grant Specificity and dynamics of transcriptional repression in retinal development
Grant A systems-level study of signaling networks and differentiation
Grant Cell-Cell Signaling In Embryonic and Retinal Development
Academic Article Ratiometric sensing of Pnt and Yan transcription factor levels confers ultrasensitivity to photoreceptor fate transitions in Drosophila.
Academic Article Inter-plane feedback coordinates cell morphogenesis and maintains 3D tissue organization in the Drosophila pupal retina.
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  • Development