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Search Results to Michael A. Glotzer

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One or more keywords matched the following properties of Glotzer, Michael A.

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keywords Cell Polarity
overview The Glotzer lab focuses on questions related to cell organization. How do cells coordinate the position of the contractile ring with the position of the spindle? By what mechanisms are cortical domains that mediate cell polarization assembled and maintained? How do cells regulate cortical contractility during developmental morphogenesis? To answer these questions, we use the nematode C. elegans, cultured human cells, budding yeast, and Drosophila as model systems and we combine forward and reverse genetics, biochemistry, and live cell imaging. Through these approaches we have discovered and extensively characterized the centralspindlin complex, a multifunctional protein complex that regulates essentially every step of cytokinesis. We have pioneered the use of optogenetics to dissect spatiotemporally regulated processes. Using these approaches, we have demonstrated that RhoA activation is sufficient to induce cleavage furrows irrespective of the position of the spindle or the stage of the cell cycle. Likewise, we obtained direct evidence that positive feedback is active during yeast cell polarization. By combining optogenetics with "conventional" genetics and live cell imaging we can directly test models for how cells endow well defined cortical regions with distinct properties that are required for complex cellular events, like cell division, cell polarization, and tissue scale morphogenetic events, such as gastrulation.

One or more keywords matched the following items that are connected to Glotzer, Michael A.

Item TypeName
Concept Cell Membrane
Concept Cell Division
Concept Cells
Concept Eukaryotic Cells
Concept Cell Cycle
Concept Epithelial Cells
Concept Cell Biology
Concept HeLa Cells
Concept NIH 3T3 Cells
Concept COS Cells
Concept Cell Cycle Proteins
Concept HEK293 Cells
Concept Time-Lapse Imaging
Concept Molecular Imaging
Concept Proliferating Cell Nuclear Antigen
Concept Imaging, Three-Dimensional
Concept Cell Line, Tumor
Concept Cell Size
Concept Cell Line
Concept Cell Physiological Phenomena
Concept Cells, Cultured
Concept Plant Cells
Academic Article Cytokinesis: regulated by destruction.
Academic Article Centrosome separation and central spindle assembly act in redundant pathways that regulate microtubule density and trigger cleavage furrow formation.
Academic Article Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners.
Academic Article Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity.
Academic Article A ubiquitin C-terminal hydrolase is required to maintain osmotic balance and execute actin-dependent processes in the early C. elegans embryo.
Academic Article Mammalian septins nomenclature.
Academic Article Cleavage furrow positioning.
Academic Article Comparative analysis of cytokinesis in budding yeast, fission yeast and animal cells.
Academic Article Cytokinesis: progress on all fronts.
Academic Article Cytokinesis: a logical GAP.
Academic Article Structural analysis of the ZEN-4/CeMKLP1 motor domain and its interaction with microtubules.
Academic Article Cell cycle regulation of central spindle assembly.
Academic Article Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle.
Academic Article Developmental regulation of central spindle assembly and cytokinesis during vertebrate embryogenesis.
Academic Article Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis.
Academic Article An ECT2-centralspindlin complex regulates the localization and function of RhoA.
Academic Article Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos.
Academic Article Clustering of centralspindlin is essential for its accumulation to the central spindle and the midbody.
Academic Article Controlling cytokinesis through promiscuous phosphorylation outside BARs.
Academic Article Cytokinesis: integrating signaling, the cytoskeleton, and membranes to create new daughter cells.
Academic Article Anillin promotes astral microtubule-directed cortical myosin polarization.
Academic Article Single cells (put a ring on it).
Academic Article RhoA activation during polarization and cytokinesis of the early Caenorhabditis elegans embryo is differentially dependent on NOP-1 and CYK-4.
Academic Article TULIPs: tunable, light-controlled interacting protein tags for cell biology.
Academic Article The molecular requirements for cytokinesis.
Academic Article Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis.
Academic Article Cytokinesis: welcome to the Rho zone.
Academic Article Cooperative assembly of CYK-4/MgcRacGAP and ZEN-4/MKLP1 to form the centralspindlin complex.
Academic Article Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.
Academic Article The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo.
Academic Article CSC-1: a subunit of the Aurora B kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1.
Academic Article Anillin is a scaffold protein that links RhoA, actin, and myosin during cytokinesis.
Academic Article The 3Ms of central spindle assembly: microtubules, motors and MAPs.
Academic Article Cytokinesis: centralspindlin moonlights as a membrane anchor.
Academic Article Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane.
Academic Article Local RhoA activation induces cytokinetic furrows independent of spindle position and cell cycle stage.
Academic Article Optical Control of Peroxisomal Trafficking.
Academic Article Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos.
Academic Article Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres.
Academic Article Cell cycle entry triggers a switch between two modes of Cdc42 activation during yeast polarization.
Academic Article Spatiotemporal Regulation of RhoA during Cytokinesis.
Grant Spatial and temporal control of cell behavior with a genetically-encoded photoswi
Grant Spatial and temporal control of Rho family GTPases
Grant Positioning the Plane of Cell Division During Cytokinesis
Grant Molecular Dissection of Cytokinesis
Academic Article Animal cell cytokinesis.
Academic Article Cytokinesis.
Academic Article Depletion of syntaxins in the early Caenorhabditis elegans embryo reveals a role for membrane fusion events in cytokinesis.
Academic Article Chromosome segregation: Samurai separation of Siamese sisters.
Academic Article CDK1 inactivation regulates anaphase spindle dynamics and cytokinesis in vivo.
Academic Article Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates.
Academic Article Cyclin is a component of maturation-promoting factor from Xenopus.
Academic Article Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans.
Academic Article The mechanism and control of cytokinesis.
Academic Article Cell polarity. The importance of being polar.
Academic Article Cell cycle. The only way out of mitosis.
Academic Article Cyclin activation of p34cdc2.
Academic Article Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis.
Academic Article CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis.
Academic Article A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos.
Academic Article Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor.
Academic Article PLK1 plays dual roles in centralspindlin regulation during cytokinesis.
Academic Article Rho1 activation recapitulates early gastrulation events in the ventral, but not dorsal, epithelium of Drosophila embryos.
Academic Article Cortical recruitment of centralspindlin and RhoA effectors during meiosis I of Caenorhabditiselegans primary spermatocytes.

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