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Search Results to Lev Becker

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One or more keywords matched the following properties of Becker, Lev

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keywords Macrophages
overview Macrophage dysregulation is a hallmark of chronic sterile inflammatory diseases including cancer, atherosclerosis, and obesity/type 2 diabetes. Because macrophages are highly influenced by their environment, we need to understand how disease-specific changes to their environment dysregulate specific pathways to drive pathogenesis. Moreover, the relationship between these macrophage pathways to those required for pathogen clearance is largely unknown, which is important because attempts to therapeutically target macrophages must preserve this important function. Comparing and contrasting macrophages across a spectrum of diseases is therefore required to elucidate disease-specific mechanisms, and to develop therapeutics that are both efficacious and safe. To enable this, my lab combines proteomic, bioinformatic, immunologic, and functional approaches to study macrophages in an unbiased manner across a spectrum of diseases. Our long-term goal is to develop a robust research program that uses a multi-disease approach to develop a comprehensive understanding of macrophage biology, and then translates this mechanistic understanding to develop therapeutics across a spectrum of human disease. To this end, my lab is developing 2 new therapies for the treatment of many cancers and anti-inflammatory therapies that do not interfere with pathogen clearance for treating atherosclerosis and type 2 diabetes.

One or more keywords matched the following items that are connected to Becker, Lev

Item TypeName
Academic Article Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages.
Academic Article Gender bias in autoimmunity is influenced by microbiota.
Academic Article Intermittent hypoxia-induced changes in tumor-associated macrophages and tumor malignancy in a mouse model of sleep apnea.
Academic Article Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages.
Academic Article Obesity and Insulin Resistance Promote Atherosclerosis through an IFN?-Regulated Macrophage Protein Network.
Academic Article Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections.
Academic Article Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity.
Academic Article Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer.
Grant 'Metabolically Activated' Macrophages in Obesity and Insulin Resistance
Grant A Macrophage Protein Network Links Obesity and type 2 Diabetes to Atherosclerosis
Academic Article Metabolic regulation of gene expression by histone lactylation.
Academic Article Hematopoietic Cell-Expressed Endothelial Nitric Oxide Protects the Liver From Insulin Resistance.
Academic Article SMRT Regulates Metabolic Homeostasis and Adipose Tissue Macrophage Phenotypes in Tandem.

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  • Macrophage