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Search Results to David Grdina

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One or more keywords matched the following properties of Grdina, David

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keywords Adaptive Responses, Genomic Instability, Radioprotectors, Amifostine, Radiation Biology
overview My research has focused on the development of radio-protective drugs for use in the prevention of radiation-induced genomic instability and subsequent processes leading to cancer development. Specifically, studies are directed at very low dose radiation and select phosphorothioate drug exposures to induce adaptive responses affecting genomic instability development.

One or more keywords matched the following items that are connected to Grdina, David

Item TypeName
Concept Amifostine
Concept Radiobiology
Concept Genomic Instability
Academic Article Antimutagenic effects of amifostine: clinical implications.
Academic Article Chemopreventive doses of amifostine confer no cytoprotection to tumor nodules growing in the lungs of mice treated with cyclophosphamide.
Academic Article WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase II alpha leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells.
Academic Article Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine.
Academic Article Misoprostol, a PGE1 analog, protects mice from fission-neutron injury.
Academic Article Protection against late effects of radiation by S-2-(3-aminopropylamino)-ethylphosphorothioic acid.
Academic Article Cytoprotection by WR-1065, the active form of amifostine, is independent of p53 status in human malignant glioma cell lines.
Academic Article Amifostine: mechanisms of action underlying cytoprotection and chemoprevention.
Academic Article Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine.
Academic Article Delayed cytoprotection after enhancement of Sod2 (MnSOD) gene expression in SA-NH mouse sarcoma cells exposed to WR-1065, the active metabolite of amifostine.
Academic Article Differential activation of nuclear transcription factor kappaB, gene expression, and proteins by amifostine's free thiol in human microvascular endothelial and glioma cells.
Academic Article Inhibition of spontaneous metastases formation by amifostine.
Academic Article Antimetastatic effectiveness of amifostine therapy following surgical removal of Sa-NH tumors in mice.
Academic Article Radioprotectants: current status and new directions.
Academic Article Relationships between cytoprotection and mutation prevention by WR-1065.
Academic Article Oral administration is as effective as intraperitoneal administration of amifostine in decreasing nitroxide EPR signal decay in vivo.
Academic Article Interaction of amifostine and ionizing radiation on transcriptional patterns of apoptotic genes expressed in human microvascular endothelial cells (HMEC).
Academic Article Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor alpha.
Academic Article Incidence of tissue toxicities in gamma ray and fission neutron-exposed mice treated with Amifostine.
Academic Article Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs.
Academic Article WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability.
Academic Article Amifostine reduces lung vascular permeability via suppression of inflammatory signalling.
Academic Article Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine.
Academic Article Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells.
Academic Article Relationship between phosphorylated histone H2AX formation and cell survival in human microvascular endothelial cells (HMEC) as a function of ionizing radiation exposure in the presence or absence of thiol-containing drugs.
Academic Article Protective effect of S-2-(3-aminopropylamino)ethylphosphorothioic acid against induction of altered hepatocyte foci in rats treated once with gamma-radiation within one day after birth.
Academic Article SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine.
Academic Article Radioprotectors: current status and new directions.
Academic Article Radioprotectors in treatment therapy to reduce risk in secondary tumor induction.
Academic Article Radiation-induced DNA single-strand breaks in the intestinal mucosal cells of mice treated with the radioprotectors WR-2721 or 16-16 dimethyl prostaglandin E2.
Academic Article Manganese superoxide dismutase interacts with a large scale of cellular and mitochondrial proteins in low-dose radiation-induced adaptive radioprotection.
Academic Article Effects of radioprotectors on DNA damage and repair, proteins, and cell-cycle progression.
Academic Article The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation.
Academic Article In vivo protection by the aminothiol WR-2721 against neutron-induced carcinogenesis.
Academic Article Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action.
Academic Article Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response.
Academic Article A comparison of radioprotection from three neutron sources and 60Co by WR-2721 and WR-151327.
Academic Article Protection by WR-2721 and WR-151327 against late effects of gamma rays and neutrons.
Academic Article Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury.
Academic Article Antimutagenic effects of radioprotector WR-2721 against fission-spectrum neurons and 60Co gamma-rays in mice.
Academic Article CyclinB1/Cdk1 phosphorylates mitochondrial antioxidant MnSOD in cell adaptive response to radiation stress.
Academic Article A manganese superoxide dismutase (SOD2)-mediated adaptive response.
Academic Article A survivin-associated adaptive response in radiation therapy.
Academic Article NF?B and Survivin-Mediated Radio-Adaptive Response.
Academic Article Protection from radiation-induced apoptosis by the radioprotector amifostine (WR-2721) is radiation dose dependent.
Academic Article Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs.
Academic Article The Increase in Animal Mortality Risk following Exposure to Sparsely Ionizing Radiation Is Not Linear Quadratic with Dose.
Academic Article ROS modifiers and NOX4 affect the expression of the survivin-associated radio-adaptive response.
Academic Article TP53 Mutational Status and ROS Effect the Expression of the Survivin-Associated Radio-Adaptive Response.

Search Criteria
  • Adaptive
  • Responses
  • Genomic Instability
  • Radioprotectors
  • Amifostine
  • Radiation Biology