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Search Results to Marsha Rosner

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overview Cancer is the second leading cause of death but, unlike heart disease, it has been a difficult disease to effectively understand or treat. The reason relates to the complexity and heterogeneity of the disease. Most tumors have complicated origins and are driven by rare mutations. Furthermore, different tissues have distinct cancers, individual tissues have multiple cancer subtypes, and tumors are composed of cells that are both genetically and phenotypically diverse. Thus, every tumor is unique and dynamic. The cause of lethality in most solid tumors such as breast cancer is the metastatic dissemination of tumor cells throughout the body. Metastasis is characterized by many distinct properties that are driven by changing stresses in the tumor microenvironment. Underlying all of these events are subcellular signaling pathways within tumor and environmental cells that are ultimately responsible for driving cells to a tumorigenic state. The current focus of my laboratory is to understand fundamental signaling mechanisms leading to the generation of tumor cells and their progression to metastatic disease, particularly in triple-negative breast cancer that lacks targeted therapies. We use systems level approaches including activity-based proteomics, RNAseq, ChIPseq, and mass spectrometry as well as computational, molecular, biophysical, cellular and mouse model-based methodologies to identify and characterize key regulators of tumor growth and metastasis. As an additional tool, we have utilized a specific physiological suppressor of metastasis, Raf Kinase Inhibitory Protein (RKIP or PEBP1), and a downstream target of RKIP in cells, BACH1, to identify both molecular and cellular mediators of metastasis. Our recent studies have shown that regulators of metastasis control multiple processes within the tumor cell microenvironment including metabolism, redox state, extracellular matrix, and recruitment and programming of tumor-associated macrophages. These factors also direct extracellular vesicles (exosomes) secreted by tumor cells to reprogram other cells in the body toward a pro-metastatic phenotype. Correlating omic-generated data from these studies with clinical data from cancer patients led to the identification of novel signaling modules that we used to build gene signatures that predict the metastatic potential of a tumor. More recently, our studies have led us to potential therapeutic treatments based on the concept of targeting key regulators of tumorigenesis, mimicking the action of metastasis suppressors such as RKIP or reprogramming signaling networks in cells to sensitize tumors to therapeutic agents.

One or more keywords matched the following items that are connected to Rosner, Marsha

Item TypeName
Concept Androgen-Binding Protein
Concept Bacterial Proteins
Concept DNA-Binding Proteins
Concept Microtubule-Associated Proteins
Concept Glial Fibrillary Acidic Protein
Concept Membrane Proteins
Concept Microfilament Proteins
Concept Nerve Tissue Proteins
Concept Muscle Proteins
Concept Protein Precursors
Concept Protein-Tyrosine Kinases
Concept Protein Binding
Concept Protein Conformation
Concept Protein Processing, Post-Translational
Concept Proto-Oncogene Proteins
Concept Protein Synthesis Inhibitors
Concept Proteins
Concept Repressor Proteins
Concept Protein Kinases
Concept Intermediate Filament Proteins
Concept Protein Biosynthesis
Concept Proto-Oncogene Proteins pp60(c-src)
Concept Oncogene Proteins
Concept Insect Proteins
Concept Mitogen-Activated Protein Kinases
Concept HMGA2 Protein
Concept Protein-Lysine 6-Oxidase
Concept Cysteine Proteinase Inhibitors
Concept Proto-Oncogene Proteins c-fos
Concept Cyclic AMP Response Element-Binding Protein
Concept Protein Structure, Tertiary
Concept RNA-Binding Proteins
Concept Immediate-Early Proteins
Concept Adenovirus E3 Proteins
Concept Phosphatidylethanolamine Binding Protein
Concept ras Proteins
Concept ets-Domain Protein Elk-1
Concept Apoptosis Regulatory Proteins
Concept Wnt1 Protein
Concept BRCA1 Protein
Concept Fas Ligand Protein
Concept Receptor Protein-Tyrosine Kinases
Concept Protein Transport
Concept Drosophila Proteins
Concept Protein Tyrosine Phosphatases
Concept Protein Structure, Secondary
Concept Intercellular Signaling Peptides and Proteins
Concept Receptors, G-Protein-Coupled
Concept F-Box Proteins
Concept Proto-Oncogene Proteins c-ets
Concept bcl-2-Associated X Protein
Concept Protein Kinase C-delta
Concept Mitogen-Activated Protein Kinase 3
Concept Mitogen-Activated Protein Kinase 7
Concept Proto-Oncogene Proteins c-bcl-2
Concept Proto-Oncogene Proteins c-raf
Concept Proto-Oncogene Proteins B-raf
Concept Cell Cycle Proteins
Concept rac GTP-Binding Proteins
Concept rap1 GTP-Binding Proteins
Concept Mitogen-Activated Protein Kinase Kinases
Concept I-kappa B Proteins
Concept BRCA2 Protein
Concept bcl-X Protein
Concept Oncogene Protein v-akt
Concept WT1 Proteins
Concept Saccharomyces cerevisiae Proteins
Concept Early Growth Response Protein 1
Concept Protein Kinase C
Concept Recombinant Proteins
Concept Protein Phosphatase 1
Concept Ubiquitin-Protein Ligases
Concept Shc Signaling Adaptor Proteins
Concept Phospholipid Transfer Proteins
Concept Adaptor Proteins, Signal Transducing
Concept Inhibitor of Differentiation Protein 1
Concept Viral Proteins
Concept Protein-Serine-Threonine Kinases
Concept Retroviridae Proteins, Oncogenic
Concept GTP-Binding Proteins
Concept Mitogen-Activated Protein Kinase 1
Concept Calcium-Calmodulin-Dependent Protein Kinases
Concept Homeodomain Proteins
Concept JNK Mitogen-Activated Protein Kinases
Concept Tumor Suppressor Proteins
Concept CASP8 and FADD-Like Apoptosis Regulating Protein
Concept Insulin Receptor Substrate Proteins
Concept Ribosomal Protein S6
Concept Ribosomal Protein S6 Kinases, 70-kDa
Concept Protein Interaction Maps
Concept Intracellular Signaling Peptides and Proteins
Concept 14-3-3 Proteins
Concept bcl-Associated Death Protein
Concept Protein Kinase C-alpha
Concept Methyl-CpG-Binding Protein 2
Concept Fanconi Anemia Complementation Group Proteins
Concept Protein Phosphatase 2
Concept Carrier Proteins
Concept Neoplasm Proteins
Concept Nuclear Proteins
Concept Recombinant Fusion Proteins
Concept Oncogene Protein pp60(v-src)
Concept Tumor Suppressor Protein p53
Concept Cyclic AMP-Dependent Protein Kinases
Concept Protein Isoforms
Concept Oncogene Proteins v-raf
Concept Vesicular Transport Proteins
Concept Adaptor Proteins, Vesicular Transport
Concept Telomere-Binding Proteins
Concept Protein Kinase Inhibitors
Concept Proto-Oncogene Proteins c-akt
Concept G-Protein-Coupled Receptor Kinase 2
Academic Article Mutations in a zinc-binding domain of human insulin-degrading enzyme eliminate catalytic activity but not insulin binding.
Academic Article Differentiation of central nervous system neuronal cells by fibroblast-derived growth factor requires at least two signaling pathways: roles for Ras and Src.
Academic Article Raf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells.
Academic Article Src tyrosine kinase mediates stimulation of Raf-1 and mitogen-activated protein kinase by the tumor promoter thapsigargin.
Academic Article Cloning and characterization of MST4, a novel Ste20-like kinase.
Academic Article Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel.
Academic Article Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth.
Academic Article A novel mitogen-activated protein kinase is responsive to Raf and mediates growth factor specificity.
Academic Article ERK7 is an autoactivated member of the MAPK family.
Academic Article ERK8, a new member of the mitogen-activated protein kinase family.
Academic Article Regulation of insulin degradation: expression of an evolutionarily conserved insulin-degrading enzyme increases degradation via an intracellular pathway.
Academic Article ERK7 expression and kinase activity is regulated by the ubiquitin-proteosome pathway.
Academic Article Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1.
Academic Article The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition.
Academic Article Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase.
Academic Article NMR assignment of rat Raf kinase inhibitor protein.
Academic Article A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle.
Academic Article Raf kinase inhibitory protein function is regulated via a flexible pocket and novel phosphorylation-dependent mechanism.
Academic Article Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Academic Article A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
Academic Article Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands.
Academic Article Raf kinase inhibitory protein (RKIP): a physiological regulator and future therapeutic target.
Academic Article Identification of novel metastasis suppressor signaling pathways for breast cancer.
Academic Article Anthrax edema factor potency depends on mode of cell entry.
Academic Article Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme.
Academic Article Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context.
Academic Article Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer.
Academic Article Histamine antagonizes serotonin and growth factor-induced mitogen-activated protein kinase activation in bovine tracheal smooth muscle cells.
Academic Article Hydrogen peroxide stimulates mitogen-activated protein kinase in bovine tracheal myocytes: implications for human airway disease.
Academic Article Conditional immortalization of neuronal cells from postmitotic cultures and adult CNS.
Academic Article Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration.
Academic Article Anti-tumor effects of an engineered "killer" transfer RNA.
Academic Article Apoptosis induced by differentiation or serum deprivation in an immortalized central nervous system neuronal cell line.
Academic Article The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis.
Academic Article Effect of complementary pathway blockade on efficacy of combination enzastaurin and rapamycin.
Academic Article A novel interplay between Rap1 and PKA regulates induction of angiogenesis in prostate cancer.
Academic Article Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis.
Academic Article Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor.
Academic Article Immortal rat hippocampal cell lines exhibit neuronal and glial lineages and neurotrophin gene expression.
Academic Article Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity.
Academic Article Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor.
Academic Article Drosophila insulin degrading enzyme and rat skeletal muscle insulin protease cleave insulin at similar sites.
Academic Article An insulin epidermal growth factor-binding protein from Drosophila has insulin-degrading activity.
Academic Article Phosphorylation at threonine-654 is not required for negative regulation of the epidermal growth factor receptor by non-phorbol tumor promoters.
Academic Article Characterization of murine-specific leukemia virus receptor from L cells.
Academic Article Basic and acidic fibroblast growth factors modulate the epidermal growth factor receptor by a protein kinase C-independent pathway.
Academic Article Identification of a novel receptor in Drosophila for both epidermal growth factor and insulin.
Academic Article Growth factors modify the epidermal growth factor receptor through multiple pathways.
Academic Article Characterization of rodent epidermal growth factor receptor transcripts using a mouse genomic probe.
Academic Article Heterologous regulation of the epidermal growth factor receptor by palytoxin, a non-12-O-tetradecanoylphorbol-13-acetate-type tumor promoter.
Academic Article Characterization of a Drosophila protein that binds both epidermal growth factor and insulin-related growth factors.
Academic Article Characterization of protein kinase C from normal and transformed cultured murine fibroblasts.
Academic Article Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor.
Academic Article Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated "MAP" kinase.
Academic Article Two independent growth factor-generated signals regulate c-fos and c-myc mRNA levels in Swiss 3T3 cells.
Academic Article Relationship of GIX antigen expression to the glycosylation of murine leukemia virus glycoprotein.
Academic Article WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis.
Academic Article Activation of mitogen-activated protein kinase by epidermal growth factor in hippocampal neurons and neuronal cell lines.
Academic Article Growth state-dependent regulation of protein kinase C in normal and transformed murine cells.
Academic Article Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium.
Academic Article Adenovirus and protein kinase C have distinct molecular requirements for regulating epidermal growth factor receptor trafficking.
Academic Article Selective cleavage by endo-beta-N-acetylglucosaminidase H at individual glycosylation sites of Sindbis virion envelope glycoproteins.
Academic Article Host-dependent variation of asparagine-linked oligosaccharides at individual glycosylation sites of Sindbis virus glycoproteins.
Academic Article Protein kinase Cdelta mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells.
Academic Article Mitogen-activated protein kinase regulates the epidermal growth factor receptor through activation of a tyrosine phosphatase.
Academic Article Insulin-like growth factor I receptor signaling in differentiation of neuronal H19-7 cells.
Academic Article Induction of epidermal growth factor receptor gene transcription by transforming growth factor beta 1: association with loss of protein binding to a negative regulatory element.
Academic Article Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.
Academic Article Functional human insulin-degrading enzyme can be expressed in bacteria.
Academic Article Different protein kinase C isoforms determine growth factor specificity in neuronal cells.
Academic Article Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein.
Academic Article Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.
Academic Article Identification of an epidermal growth factor receptor transcriptional repressor.
Academic Article Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons.
Academic Article Role of threonine residues in regulation of the epidermal growth factor receptor by protein kinase C and mitogen-activated protein kinase.
Academic Article Role of mitogen-activated protein kinase kinase in regulation of the epidermal growth factor receptor by protein kinase C.
Academic Article Proteins interacting with the tuberous sclerosis gene products.
Academic Article Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line.
Academic Article Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation.
Academic Article CDKL5/Stk9 kinase inactivation is associated with neuronal developmental disorders.
Academic Article A proline- and glutamine-rich protein promotes apoptosis in neuronal cells.
Academic Article Differential effect of cycloheximide on neuronal and glioma cells treated with chemotherapy and radiation.
Academic Article Cytoplasmic/nuclear localization of tuberin in different cell lines.
Academic Article Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations.
Academic Article Tuberous sclerosis gene products in proliferation control.
Academic Article Identification of the cleavage sites of transforming growth factor alpha by insulin-degrading enzymes.
Academic Article Role of cyclins in neuronal differentiation of immortalized hippocampal cells.
Academic Article mTOR phosphorylated at S2448 binds to raptor and rictor.
Academic Article Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme.
Academic Article Evidence for cell cycle-dependent, rapamycin-resistant phosphorylation of ribosomal protein S6 at S240/244.
Academic Article FGF induces a switch in death receptor pathways in neuronal cells.
Academic Article Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expression.
Academic Article Characterization of a Rac1 signaling pathway to cyclin D(1) expression in airway smooth muscle cells.
Academic Article Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-delta.
Academic Article Tuberin negatively affects BCL-2's cell survival function.
Academic Article Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR.
Academic Article Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas.
Academic Article Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor.
Academic Article Nuclear/cytoplasmic localization of Akt activity in the cell cycle.
Academic Article Tuberin, p27 and mTOR in different cells.
Academic Article The TSC1 gene product, hamartin, negatively regulates cell proliferation.
Academic Article Characterization of a cysteine proteinase inhibitor induced during neuronal cell differentiation.
Academic Article Ras mediates cell survival by regulating tuberin.
Academic Article MAP kinase meets mitosis: a role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation.
Academic Article Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein.
Academic Article p70 S6K1 nuclear localization depends on its mTOR-mediated phosphorylation at T389, but not on its kinase activity towards S6.
Academic Article Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7.
Academic Article 14-3-3 proteins are involved in the regulation of mammalian cell proliferation.
Academic Article NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta.
Academic Article Akt regulates nuclear/cytoplasmic localization of tuberin.
Academic Article HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.
Academic Article Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint.
Academic Article Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues.
Academic Article CDKs as therapeutic targets for the human genetic disease tuberous sclerosis?
Academic Article Embryoid body formation of human amniotic fluid stem cells depends on mTOR.
Academic Article MAP kinase regulation of the mitotic spindle checkpoint.
Academic Article RKIP regulates MAP kinase signaling in cells with defective B-Raf activity.
Academic Article Overexpression of initiator methionine tRNA leads to global reprogramming of tRNA expression and increased proliferation in human epithelial cells.
Academic Article RKIP inhibition in cervical cancer is associated with higher tumor aggressive behavior and resistance to cisplatin therapy.
Academic Article An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin.
Academic Article Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor.
Academic Article Multiple components of the T cell antigen receptor complex become tyrosine-phosphorylated upon activation.
Academic Article Cyclin D1 is required for S phase traversal in bovine tracheal myocytes.
Academic Article Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways.
Academic Article Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization.
Academic Article Tuberin activates the proapoptotic molecule BAD.
Academic Article Different cytoplasmic/nuclear distribution of S6 protein phosphorylated at S240/244 and S235/236.
Academic Article An integrated view of cyclin E function and regulation.
Academic Article A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients.
Academic Article RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2.
Academic Article Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions.
Academic Article RKIP structure drives its function: a three-state model for regulation of RKIP.
Academic Article Raf kinase inhibitory protein (RKIP) as a metastasis suppressor: regulation of signaling networks in cancer.
Academic Article Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages.
Academic Article Gene expression in local stroma reflects breast tumor states and predicts patient outcome.
Academic Article Raf kinase inhibitor protein: lessons of a better way for ß-adrenergic receptor activation in the heart.
Academic Article Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome.
Academic Article Targeting Raf Kinase Inhibitory Protein Regulation and Function.

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