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One or more keywords matched the following properties of Dolan, Mary Eileen
keywords Antineoplastic Agents
One or more keywords matched the following items that are connected to Dolan, Mary Eileen
Item TypeName
Concept Antineoplastic Agents, Alkylating
Concept Antineoplastic Agents, Phytogenic
Academic Article Pharmacokinetics of O6-benzylguanine in rats and its metabolism by rat liver microsomes.
Academic Article Effects of polyamine analogues on prostatic adenocarcinoma cells in vitro and in vivo.
Academic Article Effects of 1,2-naphthoquinones on human tumor cell growth and lack of cross-resistance with other anticancer agents.
Academic Article Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2.
Academic Article Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.
Academic Article O6-benzylguanine in humans: metabolic, pharmacokinetic, and pharmacodynamic findings.
Academic Article Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
Academic Article O6-benzylguanine and its role in chemotherapy.
Academic Article In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo.
Academic Article Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation.
Academic Article Plasma and cerebrospinal fluid pharmacokinetics of O6-benzylguanine and analogues in nonhuman primates.
Academic Article Determination of the optimal modulatory dose of O6-benzylguanine in patients with surgically resectable tumors.
Academic Article Silence is golden: gene hypermethylation and survival in large-cell lymphoma.
Academic Article A phase II trial of oral temozolomide in patients with metastatic renal cell cancer.
Academic Article Effect of O6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells.
Academic Article Temozolomide: realizing the promise and potential.
Academic Article Effect of cell cycle inhibition on Cisplatin-induced cytotoxicity.
Academic Article Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O6-benzylguanine.
Academic Article Selective enhancement of ifosfamide-induced toxicity in Chinese hamster ovary cells.
Academic Article Molecular mechanisms of resistance and toxicity associated with platinating agents.
Academic Article Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities.
Academic Article Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity.
Academic Article Effect of population and gender on chemotherapeutic agent-induced cytotoxicity.
Academic Article Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy.
Academic Article Identifying genetic variants that contribute to chemotherapy-induced cytotoxicity.
Academic Article Role of copper transporters in resistance to platinating agents.
Academic Article Whole-genome approach implicates CD44 in cellular resistance to carboplatin.
Academic Article Identification of genomic regions contributing to etoposide-induced cytotoxicity.
Academic Article Use of cell lines in the investigation of pharmacogenetic loci.
Academic Article Use of CEPH and non-CEPH lymphoblast cell lines in pharmacogenetic studies.
Academic Article Role of GADD34 in modulation of cisplatin cytotoxicity.
Academic Article Etoposide pathway.
Academic Article Cancer pharmacoethnicity: ethnic differences in susceptibility to the effects of chemotherapy.
Academic Article Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines.
Academic Article Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci.
Academic Article Identification of genetic variants contributing to cisplatin-induced cytotoxicity by use of a genomewide approach.
Academic Article The emerging role of microRNAs in drug responses.
Academic Article Chemotherapeutic-induced apoptosis: a phenotype for pharmacogenomics studies.
Academic Article Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients.
Academic Article Enhancement of cisplatin [cis-diammine dichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulum stress.
Academic Article An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers.
Academic Article Regulatory polymorphisms in ß-tubulin IIa are associated with paclitaxel-induced peripheral neuropathy.
Academic Article Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL.
Academic Article Copy number polymorphisms and anticancer pharmacogenomics.
Academic Article Susceptibility loci involved in cisplatin-induced cytotoxicity and apoptosis.
Academic Article Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.
Academic Article Lack of evidence for a polymorphism at codon 160 of human O6-alkylguanine-DNA alkyltransferase gene in normal tissue and cancer.
Academic Article Pharmacokinetics of oral O6-benzylguanine and evidence of interaction with oral ketoconazole in the rat.
Academic Article Irinotecan activation by human carboxylesterases in colorectal adenocarcinoma cells.
Academic Article A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity.
Academic Article Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding.
Academic Article Approaches to the discovery of pharmacogenomic markers in oncology: 2000-2010-2020.
Academic Article Germline polymorphisms discovered via a cell-based, genome-wide approach predict platinum response in head and neck cancers.
Academic Article Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans.
Academic Article An analysis of 1-(2-chloroethyl)-1-nitrosourea activity at the cellular level.
Academic Article Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.
Academic Article Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.
Academic Article Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.
Academic Article O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma.
Academic Article O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials.
Academic Article Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study.
Academic Article Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea.
Academic Article Modified guanines representing O(6)-alkylation by the cyclophosphamide metabolites acrolein and chloroacetaldehyde: synthesis, stability, and ab initio studies.
Academic Article Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase.
Academic Article Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity.
Academic Article Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft.
Academic Article Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.
Academic Article O6-benzylguanine-mediated enhancement of chemotherapy.
Academic Article Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial.
Academic Article Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
Academic Article Mouse models of human AML accurately predict chemotherapy response.
Academic Article The kinase inhibitor O6-cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2.
Academic Article Cancer pharmacogenomics: strategies and challenges.
Academic Article Testicular cancer survivorship: research strategies and recommendations.
Academic Article Multicenter phase II trial of temozolomide in mycosis fungoides/sezary syndrome: correlation with O6-methylguanine-DNA methyltransferase and mismatch repair proteins.
Academic Article Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine.
Academic Article Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
Academic Article Mechanisms of resistance to the toxicity of cyclophosphamide.
Academic Article Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft.
Academic Article Etoposide sensitivity does not predict MLL rearrangements or risk of therapy-related acute myeloid leukemia.
Academic Article Protein quantitative trait loci identify novel candidates modulating cellular response to chemotherapy.
Academic Article Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia.
Academic Article Modeling chemotherapeutic neurotoxicity with human induced pluripotent stem cell-derived neuronal cells.
Academic Article The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide.
Academic Article Chemotherapy-induced peripheral neurotoxicity and ototoxicity: new paradigms for translational genomics.
Academic Article Integrating cell-based and clinical genome-wide studies to identify genetic variants contributing to treatment failure in neuroblastoma patients.
Academic Article Hydroxylation and N-dechloroethylation of Ifosfamide and deuterated Ifosfamide by the human cytochrome p450s and their commonly occurring polymorphisms.
Academic Article Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy.
Academic Article Evaluation of inter-batch differences in stem-cell derived neurons.
Academic Article Comprehensive Audiometric Analysis of Hearing Impairment and Tinnitus After Cisplatin-Based Chemotherapy in Survivors of Adult-Onset Cancer.
Academic Article Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity.
Academic Article Identification of Novel Protein Expression Changes Following Cisplatin Treatment and Application to Combination Therapy.
Academic Article Gene and MicroRNA Perturbations of Cellular Response to Pemetrexed Implicate Biological Networks and Enable Imputation of Response in Lung Adenocarcinoma.
Academic Article Racial disparities in omission of oncotype DX but no racial disparities in chemotherapy receipt following completed oncotype DX test results.
Academic Article Clinical and Genome-wide Analysis of Cisplatin-induced Tinnitus Implicates Novel Ototoxic Mechanisms.
Academic Article Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy.
Academic Article Genetically regulated expression underlies cellular sensitivity to chemotherapy in diverse populations.
Academic Article Pharmacogenomics of cisplatin-induced neurotoxicities: Hearing loss, tinnitus, and peripheral sensory neuropathy.
Academic Article Prevalence and risk factors for ototoxicity after cisplatin-based chemotherapy.
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  • Antineoplastic Agents