| Item Type | Name |
|
Concept
|
Antineoplastic Agents, Alkylating
|
|
Concept
|
Antineoplastic Agents, Phytogenic
|
|
Academic Article
|
Pharmacokinetics of O6-benzylguanine in rats and its metabolism by rat liver microsomes.
|
|
Academic Article
|
Effects of polyamine analogues on prostatic adenocarcinoma cells in vitro and in vivo.
|
|
Academic Article
|
Effects of 1,2-naphthoquinones on human tumor cell growth and lack of cross-resistance with other anticancer agents.
|
|
Academic Article
|
Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2.
|
|
Academic Article
|
Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.
|
|
Academic Article
|
O6-benzylguanine in humans: metabolic, pharmacokinetic, and pharmacodynamic findings.
|
|
Academic Article
|
Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
|
|
Academic Article
|
O6-benzylguanine and its role in chemotherapy.
|
|
Academic Article
|
In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo.
|
|
Academic Article
|
Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation.
|
|
Academic Article
|
Plasma and cerebrospinal fluid pharmacokinetics of O6-benzylguanine and analogues in nonhuman primates.
|
|
Academic Article
|
Determination of the optimal modulatory dose of O6-benzylguanine in patients with surgically resectable tumors.
|
|
Academic Article
|
Silence is golden: gene hypermethylation and survival in large-cell lymphoma.
|
|
Academic Article
|
A phase II trial of oral temozolomide in patients with metastatic renal cell cancer.
|
|
Academic Article
|
Effect of O6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells.
|
|
Academic Article
|
Temozolomide: realizing the promise and potential.
|
|
Academic Article
|
Effect of cell cycle inhibition on Cisplatin-induced cytotoxicity.
|
|
Academic Article
|
Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O6-benzylguanine.
|
|
Academic Article
|
Selective enhancement of ifosfamide-induced toxicity in Chinese hamster ovary cells.
|
|
Academic Article
|
Molecular mechanisms of resistance and toxicity associated with platinating agents.
|
|
Academic Article
|
Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities.
|
|
Academic Article
|
Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity.
|
|
Academic Article
|
Effect of population and gender on chemotherapeutic agent-induced cytotoxicity.
|
|
Academic Article
|
Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy.
|
|
Academic Article
|
Identifying genetic variants that contribute to chemotherapy-induced cytotoxicity.
|
|
Academic Article
|
Role of copper transporters in resistance to platinating agents.
|
|
Academic Article
|
Whole-genome approach implicates CD44 in cellular resistance to carboplatin.
|
|
Academic Article
|
Identification of genomic regions contributing to etoposide-induced cytotoxicity.
|
|
Academic Article
|
Use of cell lines in the investigation of pharmacogenetic loci.
|
|
Academic Article
|
Use of CEPH and non-CEPH lymphoblast cell lines in pharmacogenetic studies.
|
|
Academic Article
|
Role of GADD34 in modulation of cisplatin cytotoxicity.
|
|
Academic Article
|
Etoposide pathway.
|
|
Academic Article
|
Cancer pharmacoethnicity: ethnic differences in susceptibility to the effects of chemotherapy.
|
|
Academic Article
|
Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines.
|
|
Academic Article
|
Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci.
|
|
Academic Article
|
Identification of genetic variants contributing to cisplatin-induced cytotoxicity by use of a genomewide approach.
|
|
Academic Article
|
The emerging role of microRNAs in drug responses.
|
|
Academic Article
|
Chemotherapeutic-induced apoptosis: a phenotype for pharmacogenomics studies.
|
|
Academic Article
|
Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients.
|
|
Academic Article
|
Enhancement of cisplatin [cis-diammine dichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulum stress.
|
|
Academic Article
|
An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers.
|
|
Academic Article
|
Regulatory polymorphisms in ß-tubulin IIa are associated with paclitaxel-induced peripheral neuropathy.
|
|
Academic Article
|
Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL.
|
|
Academic Article
|
Copy number polymorphisms and anticancer pharmacogenomics.
|
|
Academic Article
|
Susceptibility loci involved in cisplatin-induced cytotoxicity and apoptosis.
|
|
Academic Article
|
Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.
|
|
Academic Article
|
Lack of evidence for a polymorphism at codon 160 of human O6-alkylguanine-DNA alkyltransferase gene in normal tissue and cancer.
|
|
Academic Article
|
Pharmacokinetics of oral O6-benzylguanine and evidence of interaction with oral ketoconazole in the rat.
|
|
Academic Article
|
Irinotecan activation by human carboxylesterases in colorectal adenocarcinoma cells.
|
|
Academic Article
|
A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity.
|
|
Academic Article
|
Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding.
|
|
Academic Article
|
Approaches to the discovery of pharmacogenomic markers in oncology: 2000-2010-2020.
|
|
Academic Article
|
Germline polymorphisms discovered via a cell-based, genome-wide approach predict platinum response in head and neck cancers.
|
|
Academic Article
|
Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans.
|
|
Academic Article
|
An analysis of 1-(2-chloroethyl)-1-nitrosourea activity at the cellular level.
|
|
Academic Article
|
Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.
|
|
Academic Article
|
Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.
|
|
Academic Article
|
Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.
|
|
Academic Article
|
O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma.
|
|
Academic Article
|
O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials.
|
|
Academic Article
|
Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study.
|
|
Academic Article
|
Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea.
|
|
Academic Article
|
Modified guanines representing O(6)-alkylation by the cyclophosphamide metabolites acrolein and chloroacetaldehyde: synthesis, stability, and ab initio studies.
|
|
Academic Article
|
Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase.
|
|
Academic Article
|
Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity.
|
|
Academic Article
|
Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft.
|
|
Academic Article
|
Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.
|
|
Academic Article
|
O6-benzylguanine-mediated enhancement of chemotherapy.
|
|
Academic Article
|
Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial.
|
|
Academic Article
|
Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
|
|
Academic Article
|
Mouse models of human AML accurately predict chemotherapy response.
|
|
Academic Article
|
The kinase inhibitor O6-cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2.
|
|
Academic Article
|
Cancer pharmacogenomics: strategies and challenges.
|
|
Academic Article
|
Testicular cancer survivorship: research strategies and recommendations.
|
|
Academic Article
|
Multicenter phase II trial of temozolomide in mycosis fungoides/sezary syndrome: correlation with O6-methylguanine-DNA methyltransferase and mismatch repair proteins.
|
|
Academic Article
|
Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine.
|
|
Academic Article
|
Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
|
|
Academic Article
|
Mechanisms of resistance to the toxicity of cyclophosphamide.
|
|
Academic Article
|
Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft.
|
|
Academic Article
|
Etoposide sensitivity does not predict MLL rearrangements or risk of therapy-related acute myeloid leukemia.
|
|
Academic Article
|
Protein quantitative trait loci identify novel candidates modulating cellular response to chemotherapy.
|
|
Academic Article
|
Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia.
|
|
Academic Article
|
Modeling chemotherapeutic neurotoxicity with human induced pluripotent stem cell-derived neuronal cells.
|
|
Academic Article
|
The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide.
|
|
Academic Article
|
Chemotherapy-induced peripheral neurotoxicity and ototoxicity: new paradigms for translational genomics.
|
|
Academic Article
|
Integrating cell-based and clinical genome-wide studies to identify genetic variants contributing to treatment failure in neuroblastoma patients.
|
|
Academic Article
|
Hydroxylation and N-dechloroethylation of Ifosfamide and deuterated Ifosfamide by the human cytochrome p450s and their commonly occurring polymorphisms.
|
|
Academic Article
|
Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy.
|
|
Academic Article
|
Evaluation of inter-batch differences in stem-cell derived neurons.
|
|
Academic Article
|
Comprehensive Audiometric Analysis of Hearing Impairment and Tinnitus After Cisplatin-Based Chemotherapy in Survivors of Adult-Onset Cancer.
|
|
Academic Article
|
Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity.
|
|
Academic Article
|
Identification of Novel Protein Expression Changes Following Cisplatin Treatment and Application to Combination Therapy.
|
|
Academic Article
|
Gene and MicroRNA Perturbations of Cellular Response to Pemetrexed Implicate Biological Networks and Enable Imputation of Response in Lung Adenocarcinoma.
|
|
Academic Article
|
Racial disparities in omission of oncotype DX but no racial disparities in chemotherapy receipt following completed oncotype DX test results.
|
|
Academic Article
|
Clinical and Genome-wide Analysis of Cisplatin-induced Tinnitus Implicates Novel Ototoxic Mechanisms.
|
|
Academic Article
|
Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy.
|
|
Academic Article
|
Genetically regulated expression underlies cellular sensitivity to chemotherapy in diverse populations.
|
|
Academic Article
|
Pharmacogenomics of cisplatin-induced neurotoxicities: Hearing loss, tinnitus, and peripheral sensory neuropathy.
|
|
Academic Article
|
Prevalence and risk factors for ototoxicity after cisplatin-based chemotherapy.
|