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One or more keywords matched the following properties of Dolan, Mary Eileen
keywords Genome Wide Association Studies
overview The Dolan lab is focused on improving the quality of life of cancer patients through the identification of genetic variants associated with risk for severe and persistent toxicities following chemotherapy (i.e. peripheral neuropathy, ototoxicity, tinnitus), particularly in children and young adults whose adverse sequelae could persist throughout their lifetimes. To this end, they perform clinical genome wide association studies to identify genetic variants associated with toxicity in patients following chemotherapy and determine whether there is shared genetic architecture with idiopathic forms of these traits. They develop preclinical models to elucidate the biochemical and cellular impact of genes identified in clinical studies of chemotherapeutic toxicity. Their approach integrates multiple large datasets including: genetic variation, gene expression, miRNA, modified cytosine, transcription factor levels and chemotherapeutic induced pharmacologic traits. Her laboratory made the seminal observation that chemotherapeutic-induced cytotoxicity is a heritable trait and that pharmacologic SNPs, identified through GWAS, are enriched in expression quantitative trait loci. More recently, her laboratory has developed an induced pluripotent stem cell derived neuronal cell model to evaluate genes contributing to chemotherapeutic-induced neuropathy, a common adverse event of multiple chemotherapeutic agents. They are creating a resource of human induced pluripotent stem cell derived neurons from well-phenotyped cancer survivors following treatment with paclitaxel, vincristine or cisplatin to be used to identify an in vitro toxicity readout that parallels the clinical phenotype. The models they are developing will have broad applicability for gaining insight on druggable targets to treat or prevent this devastating side effect of chemotherapy and providing an understanding of the genetic components and genes contributing to severe toxicity.
One or more keywords matched the following items that are connected to Dolan, Mary Eileen
Item TypeName
Concept Genome-Wide Association Study
Academic Article Population-specific GSTM1 copy number variation.
Academic Article Use of cell lines in the investigation of pharmacogenetic loci.
Academic Article Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines.
Academic Article SCAN: SNP and copy number annotation.
Academic Article Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS.
Academic Article Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci.
Academic Article Chemotherapeutic-induced apoptosis: a phenotype for pharmacogenomics studies.
Academic Article Population differences in microRNA expression and biological implications.
Academic Article Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients.
Academic Article Functional consequences of PRPF39 on distant genes and cisplatin sensitivity.
Academic Article Lymphoblastoid cell lines in pharmacogenomic discovery and clinical translation.
Academic Article Comprehensive evaluation of the contribution of X chromosome genes to platinum sensitivity.
Academic Article An integrated genomic approach to the assessment and treatment of acute myeloid leukemia.
Academic Article An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers.
Academic Article Copy number polymorphisms and anticancer pharmacogenomics.
Academic Article The use of genomic information to optimize cancer chemotherapy.
Academic Article Identification of novel germline polymorphisms governing capecitabine sensitivity.
Academic Article Germline polymorphisms discovered via a cell-based, genome-wide approach predict platinum response in head and neck cancers.
Academic Article Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans.
Academic Article Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.
Academic Article Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations.
Academic Article Cancer pharmacogenomics: strategies and challenges.
Academic Article Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients.
Academic Article Testicular cancer survivorship: research strategies and recommendations.
Academic Article Identification and validation of genetic variants that influence transcription factor and cell signaling protein levels.
Academic Article Protein quantitative trait loci identify novel candidates modulating cellular response to chemotherapy.
Academic Article Pharmacokinetics and pharmacogenomics of daunorubicin in children: a report from the Children's Oncology Group.
Academic Article Genetic and epigenetic variants contributing to clofarabine cytotoxicity.
Academic Article Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia.
Academic Article EPS8 inhibition increases cisplatin sensitivity in lung cancer cells.
Academic Article Chemotherapy-induced peripheral neurotoxicity and ototoxicity: new paradigms for translational genomics.
Academic Article Identification of genetic variants associated with capecitabine-induced hand-foot syndrome through integration of patient and cell line genomic analyses.
Academic Article Integrating cell-based and clinical genome-wide studies to identify genetic variants contributing to treatment failure in neuroblastoma patients.
Academic Article Linking the genetic architecture of cytosine modifications with human complex traits.
Academic Article Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy.
Academic Article Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy.
Academic Article Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity.
Academic Article Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach.
Academic Article Clinical and Genome-Wide Analysis of Cisplatin-Induced Peripheral Neuropathy in Survivors of Adult-Onset Cancer.
Academic Article Genome-Wide Association Studies of Chemotherapeutic Toxicities: Genomics of Inequality.
Academic Article Integration of genetic and functional genomics data to uncover chemotherapeutic induced cytotoxicity.
Academic Article Genetic and Modifiable Risk Factors Contributing to Cisplatin-induced Toxicities.
Academic Article Clinical and Genome-wide Analysis of Cisplatin-induced Tinnitus Implicates Novel Ototoxic Mechanisms.
Academic Article Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy.
Academic Article Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors.
Academic Article Genetically regulated expression underlies cellular sensitivity to chemotherapy in diverse populations.
Academic Article Clinical and genetic risk factors for radiation-associated ototoxicity: A report from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort.
Academic Article Pharmacogenomics of cisplatin-induced neurotoxicities: Hearing loss, tinnitus, and peripheral sensory neuropathy.
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  • Genome Wide Association Studies