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Search Results to Manyuan Long

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One or more keywords matched the following properties of Long, Manyuan

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overview Since my doctoral study in California in the early 1990s, I have been focusing on the study of a new and major scientific problem: How does a gene originate and evolve? The approaches I have developed and are being used to investigate the new gene problem include theoretical, computational, and molecular experimental approaches. We are currently exploring following scientific issues: #Evolution of gene expression networks by integration of new genes; #Phenotypic effects and functions of new genes; #Evolutionary analysis of gene interactions with new genes; #Copy number variation within Drosophila populations; #Evolution of sex chromosomes and sex-related genes; #Genes and Genomes in plants: high origination rate of chimeric genes in the grass family. Our scientific works have generated scientific and societal impacts: Scientific impacts: #The American Association for the Advancement of Science (AAAS) summarized my contribution when conferring me with a fellow honor (2014 AAAS Fellow) as “You are being honored: For distinguished contributions to the fields of molecular evolution and genetics, particularly for starting and leading the area of new gene evolution using experimental and computational genomics and molecular biology”. #Our discovers have helped shape the new chapters and sections about new gene evolution in major textbooks pf evolutionary biology (e.g. Douglas Futuyma, 2009 and 2005, Evolution, Sinauer, Massachusetts; Michael Lynch, 2007, The Origins of Genome Architecture, Sinauer, Massachesetts; Wen-Hsiung Li, 1997, Molecular Evolution, Sinauer, Massachusetts; Roderic Page and Edward Holmes, 1998, Molecular Evolution. Blackwell Science London). Societal impacts: #New York Times, Washington Times, Chicago Tribune, Sacramento Bee, The Huffington Post, La Vanguardia, the New Scientist, the Scientist, Discover, La Recherche, Wen Hui Bao, and other news media in US, Europe, East Asia reported in various languages his scientific discovers and commentaries. #Our research results summarized in a Nature Rev Genet article (Manyuan Long et al, 2003) were cited as major evidence for a successful defense of Amendment I to the United States Constitution in the nationally concerned case of Kitzmiller et al. vs. Dover Area School District in Pennsylvania in 2005.

One or more keywords matched the following items that are connected to Long, Manyuan

Item TypeName
Concept Drosophila
Concept Drosophila melanogaster
Concept Drosophila Proteins
Academic Article Origin of sphinx, a young chimeric RNA gene in Drosophila melanogaster.
Academic Article Rapid divergence of gene duplicates on the Drosophila melanogaster X chromosome.
Academic Article The origin of the Jingwei gene and the complex modular structure of its parental gene, yellow emperor, in Drosophila melanogaster.
Academic Article A new function evolved from gene fusion.
Academic Article Origin of new genes: evidence from experimental and computational analyses.
Academic Article Retroposed new genes out of the X in Drosophila.
Academic Article Dntf-2r, a young Drosophila retroposed gene with specific male expression under positive Darwinian selection.
Academic Article Nucleotide variation and recombination along the fourth chromosome in Drosophila simulans.
Academic Article Intron presence-absence polymorphism in Drosophila driven by positive Darwinian selection.
Academic Article Expansion of genome coding regions by acquisition of new genes.
Academic Article Sex chromosomes and male functions: where do new genes go?
Academic Article Excess of amino acid substitutions relative to polymorphism between X-linked duplications in Drosophila melanogaster.
Academic Article Duplication-degeneration as a mechanism of gene fission and the origin of new genes in Drosophila species.
Academic Article The evolution of courtship behaviors through the origination of a new gene in Drosophila.
Academic Article Evolving protein functional diversity in new genes of Drosophila.
Academic Article Translational effects of differential codon usage among intragenic domains of new genes in Drosophila.
Academic Article Natural selection shapes genome-wide patterns of copy-number polymorphism in Drosophila melanogaster.
Academic Article Recombination yet inefficient selection along the Drosophila melanogaster subgroup's fourth chromosome.
Academic Article Detection of intergenic non-coding RNAs expressed in the main developmental stages in Drosophila melanogaster.
Academic Article Retrogene movement within- and between-chromosomes in the evolution of Drosophila genomes.
Academic Article A new retroposed gene in Drosophila heterochromatin detected by microarray-based comparative genomic hybridization.
Academic Article Age-dependent chromosomal distribution of male-biased genes in Drosophila.
Academic Article A cautionary note for retrocopy identification: DNA-based duplication of intron-containing genes significantly contributes to the origination of single exon genes.
Academic Article General gene movement off the X chromosome in the Drosophila genus.
Academic Article Evolution of genes and genomes on the Drosophila phylogeny.
Academic Article Deficiency of X-linked inverted duplicates with male-biased expression and the underlying evolutionary mechanisms in the Drosophila genome.
Academic Article Repetitive element-mediated recombination as a mechanism for new gene origination in Drosophila.
Academic Article Adaptive evolution and the birth of CTCF binding sites in the Drosophila genome.
Academic Article Stage-specific expression profiling of Drosophila spermatogenesis suggests that meiotic sex chromosome inactivation drives genomic relocation of testis-expressed genes.
Academic Article Mutational bias shaping fly copy number variation: implications for genome evolution.
Academic Article Direct evidence for postmeiotic transcription during Drosophila melanogaster spermatogenesis.
Academic Article Highly tissue specific expression of Sphinx supports its male courtship related role in Drosophila melanogaster.
Academic Article Re-analysis of the larval testis data on meiotic sex chromosome inactivation revealed evidence for tissue-specific gene expression related to the drosophila X chromosome.
Academic Article Drosophila duplication hotspots are associated with late-replicating regions of the genome.
Academic Article New genes in Drosophila quickly become essential.
Academic Article Origin of new genes and source for N-terminal domain of the chimerical gene, jingwei, in Drosophila.
Academic Article Gene duplication and evolution.
Academic Article Nucleotide variation along the Drosophila melanogaster fourth chromosome.
Academic Article Origination of an X-linked testes chimeric gene by illegitimate recombination in Drosophila.
Academic Article Recurrent tandem gene duplication gave rise to functionally divergent genes in Drosophila.
Academic Article Evolution of enzymatic activities of testis-specific short-chain dehydrogenase/reductase in Drosophila.
Academic Article Reshaping of global gene expression networks and sex-biased gene expression by integration of a young gene.
Academic Article Frequent recent origination of brain genes shaped the evolution of foraging behavior in Drosophila.
Academic Article Roles of young serine-endopeptidase genes in survival and reproduction revealed rapid evolution of phenotypic effects at adult stages.
Academic Article Segmental dataset and whole body expression data do not support the hypothesis that non-random movement is an intrinsic property of Drosophila retrogenes.
Academic Article New gene evolution: little did we know.
Academic Article New genes important for development.
Academic Article A long-term demasculinization of X-linked intergenic noncoding RNAs in Drosophila melanogaster.
Academic Article LTR-mediated retroposition as a mechanism of RNA-based duplication in metazoans.
Academic Article Genetic Architecture of Natural Variation Underlying Adult Foraging Behavior That Is Essential for Survival of Drosophila melanogaster.
Academic Article Gene duplicates resolving sexual conflict rapidly evolved essential gametogenesis functions.

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