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Search Results to John Alverdy

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overview John Alverdy, MD, has run a continuously funded NIH-funded laboratory that studies the molecular interactions of bacteria and the intestinal mucosa in order to understand how life-threatening infections arise after trauma and major surgery and during critical illness. He has developed several anti-infective polymer-based compounds that can attenuate the virulence of several multi-drug resistant pathogens that cause life threatening infections in surgical patients and works with the IME to synthesize, refine, and scale the compounds for pre-clinical testing. The Alverdy lab seeks to better understand the regulation of virulence expression among potential pathogens through investigating the characteristics of the microbial context, molecular machinery that senses that context, and ultimately the lethal combinations of virulence expression that leads to disease. The majority of our work has focused on the sense and response virulence mechanisms of Pseudomonas aeruginosa, a well characterized and clinically important pathogen. We have shown a remarkable potential for this organisms to respond to host environmental cues related to stress, ischemia, immune activation and nutrient depletion. With this core model of environmental regulation of virulence expression, we are pursuing applications in intestinal transplantation, anastomotic and radiation physiology, necrotizing enterocolitis and ischemia/reperfusion injury. We are also investigating similar sense and response mechanisms in other clinically important organisms, including Staphylococcus aureus and Candida albicans. Finally, we are interested in developing virulence-based therapies to prevent virulence activation through modifications in microenvironment of the stressed host such as phosphate repletion and polymer-mediated mucosal replacement therapies. The ultimate goal of understanding microbial virulence is to provide clinical tools to improve the care of patients. However the complexity of the host-pathogen interaction and the vast amounts of mechanistic information available constitutes a formidable barrier to translational research. Computational agent based modeling is a well suited to dynamically represent mechanistic detail in a modifiable context to recapitulate cellular behavior at the tissue, organ and patient levels.

One or more keywords matched the following items that are connected to Alverdy, John

Item TypeName
Concept Acute Disease
Concept Career Choice
Concept Critical Care
Concept Intensive Care Units
Concept Patient Acceptance of Health Care
Concept Patient Care Team
Concept Preoperative Care
Concept Postoperative Nausea and Vomiting
Concept Perioperative Care
Concept Postoperative Complications
Concept Acute Lung Injury
Concept Pancreatitis, Acute Necrotizing
Concept Health Care Surveys
Concept Acute Kidney Injury
Academic Article Characteristics of the intestinal epithelial barrier during dietary manipulation and glucocorticoid stress.
Academic Article Surgical stress, bacteria, and mucosal immune function.
Academic Article The impact of morbid obesity on oxygen cost of breathing (VO(2RESP)) at rest.
Academic Article Influence of the critically ill state on host-pathogen interactions within the intestine: gut-derived sepsis redefined.
Academic Article The effects of Roux-en-Y gastric bypass surgery on body image.
Academic Article The impact of stress and nutrition on bacterial-host interactions at the intestinal epithelial surface.
Academic Article Depressed mood in class III obesity predicted by weight-related stigma.
Academic Article Predictors of patient selection in bariatric surgery.
Academic Article Use of double-balloon enteroscopy to perform PEG in the excluded stomach after Roux-en-Y gastric bypass.
Academic Article The use of multidisciplinary teams to evaluate bariatric surgery patients: results from a national survey in the U.S.A.
Academic Article Duodenal switch gastric bypass surgery for morbid obesity: imaging of postsurgical anatomy and postoperative gastrointestinal complications.
Academic Article The molecular Koch's postulates and surgical infection: a view forward.
Academic Article Changes in desired body shape after bariatric surgery.
Academic Article Carotid-esophageal fistula following a penetrating neck injury: case report.
Academic Article The effect of nutrition on gastrointestinal barrier function.
Academic Article Causes and consequences of bacterial adherence to mucosal epithelia during critical illness.
Academic Article Vitamin D deficiency in preoperative bariatric surgery patients.
Academic Article Laparoscopic intracavitary debridement of peripancreatic necrosis: preliminary report and description of the technique.
Academic Article Assessment of binge eating disorder in morbidly obese patients evaluated for gastric bypass: SCID versus QEWP-R.
Academic Article Temporary loss of limb function secondary to soft tissue calcification in a patient with rhabdomyolysis-induced acute renal failure.
Academic Article Why patients seek bariatric surgery: a qualitative and quantitative analysis of patient motivation.
Academic Article Protective effects of high-molecular weight polyethylene glycol (PEG) in human lung endothelial cell barrier regulation: role of actin cytoskeletal rearrangement.
Academic Article Diagnosis and treatment of atypical presentations of hiatal hernia following bariatric surgery.
Academic Article Polymer therapeutics move into the sepsis space.
Academic Article History, goals, and technique of laparoscopic pancreatic necrosectomy.
Academic Article The intestinal environment of surgical injury transforms Pseudomonas aeruginosa into a discrete hypervirulent morphotype capable of causing lethal peritonitis.
Academic Article A catheter-based suture-free approach to bilioenteric anastomosis: a pilot study.
Academic Article Membership and behavior of ultra-low-diversity pathogen communities present in the gut of humans during prolonged critical illness.
Academic Article The opposing forces of the intestinal microbiome and the emerging pathobiome.
Academic Article Pseudomonas aeruginosa wound infection involves activation of its iron acquisition system in response to fascial contact.
Academic Article During critical illness the gut does not pass the acid test.
Academic Article The Shift of an Intestinal "Microbiome" to a "Pathobiome" Governs the Course and Outcome of Sepsis Following Surgical Injury.
Academic Article The intestinal microbiome and surgical disease.
Academic Article Prevention of Perioperative Anastomotic Healing Complications: Anastomotic Stricture and Anastomotic Leak.
Academic Article The gut microbiota and gastrointestinal surgery.
Academic Article The role of the microbiota in surgical recovery.
Academic Article Influence of nutrition therapy on the intestinal microbiome.
Academic Article Modeling Acinetobacter baumannii wound infections: The critical role of iron.
Academic Article Collapse of the Microbiome, Emergence of the Pathobiome, and the Immunopathology of Sepsis.
Academic Article Can Methicillin-resistant Staphylococcus aureus Silently Travel From the Gut to the Wound and Cause Postoperative Infection? Modeling the "Trojan Horse Hypothesis".
Academic Article Smoking and Postoperative Surgical Site Infection: Where There's Smoke, There's Fire.
Academic Article Fecal Micobiota Transplantation to Treat Sepsis of Unclear Etiology.
Academic Article Preparing the Bowel for Surgery: Learning from the Past and Planning for the Future.
Academic Article Microbiome Medicine: This Changes Everything.
Academic Article Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery.
Academic Article Hypermetabolism and Nutritional Support in Sepsis.
Academic Article The wound environment, microbial virulence and postoperative infection: Practical lessons for the surgeon.
Academic Article Surgeon as Basic Bench Scientist: A Play in Three Acts.
Academic Article Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation After Colorectal Surgery.
Academic Article Low-fat/high-fibre diet prehabilitation improves anastomotic healing via the microbiome: an experimental model.
Academic Article Bowel preparation under siege.
Academic Article Western-type diet influences mortality from necrotising pancreatitis and demonstrates a central role for butyrate.
Academic Article Patient Acceptance of Routine Serial Postoperative Endoscopy Following Low Anterior Resection (LAR) and Its Ability to Detect Biomarkers in Anastomotic Lavage Fluid.
Academic Article Bowel preparation in colorectal surgery: the day of reckoning is here.
Academic Article Case presentation and panel discussion: Critical illness.
Academic Article Autologous Posterior Rectus Sheath as a Vascularized Onlay Flap: a Novel Approach to Hiatal Hernia Repair.
Academic Article Re-examining chemically defined liquid diets through the lens of the microbiome.

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