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One or more keywords matched the following properties of Green, William
keywords Cell Biology of Neurons
overview My research is focused on ionotropic neurotransmitter receptors, the receptors responsible for the rapid postsynaptic response in nerve and muscle. These receptors are large oligomeric membrane proteins with subunits surrounding an ion channel that opens when neurotransmitters bind to the receptor. There are two different families of ionotropic neurotransmitter receptors. One family includes nicotinic acetylcholine receptors (AChRs), GABA and glycine receptors, and the other family are glutamate receptors, both NMDA- and AMPA-type glutamate receptors. The overall goal of my research is to understand how nerve and muscle build these receptors and traffic them specifically to and from synapses. These events regulate the number, density and function of the receptors at synapses, which helps define synaptic strength. The same events underlie learning and memory formation, and when they fail, can contribute to a number of diseases including Alzheimer’s disease, Huntington’s Disease, Myasthenia Gravis and Myasthenic Syndromes. There are several projects ongoing in my lab characterizing the basic cell biology of these receptors, which include receptor assembly, trafficking and clustering. Assembly refers to the processes that transform newly synthesized subunits into functional receptors usually in the endoplasmic reticulum. Trafficking refers to the processes that transport the receptors to and from different location in cells and targets them to these locations. Clustering is the process that packs and maintains the receptors in regions of high density such as synapses. Recently, we have developed new techniques for assaying the protein post-translation modification known as palmitoylation. This work has led to several collaborations in which we are helping to characterize the palmitoylation of a number of different proteins. I also am collaborating with Dr. Paul Selvin (University of Illinois) developing fluorescent single-molecule methods to characterize neurotransmitter receptor subunit composition, stoichiometry and the diffusion/trafficking of these receptors.
One or more keywords matched the following items that are connected to Green, William
Item TypeName
Concept Motor Neurons
Concept Neurons
Concept GABAergic Neurons
Concept Dopaminergic Neurons
Academic Article Neuronal alpha-bungarotoxin receptors are alpha7 subunit homomers.
Academic Article Up-regulation of nicotinic receptors by nicotine varies with receptor subtype.
Academic Article Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction.
Academic Article Intermittent nicotine exposure upregulates nAChRs in VTA dopamine neurons and sensitises locomotor responding to the drug.
Academic Article CASK regulates SAP97 conformation and its interactions with AMPA and NMDA receptors.
Academic Article Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants.
Academic Article Stable small quantum dots for synaptic receptor tracking on live neurons.
Academic Article SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway.
Academic Article Palmitoylation regulates glutamate receptor distributions in postsynaptic densities through control of PSD95 conformation and orientation.
Academic Article Essential roles of the acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning.
Academic Article Synaptic contact between embryonic neurons and acetylcholine receptor-fibroblast.
Academic Article Small quantum dots conjugated to nanobodies as immunofluorescence probes for nanometric microscopy.
Academic Article Altered palmitoylation and neuropathological deficits in mice lacking HIP14.
Academic Article Acetylcholine receptor assembly is stimulated by phosphorylation of its gamma subunit.
Academic Article Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.
Academic Article Super-resolution imaging of synaptic and Extra-synaptic AMPA receptors with different-sized fluorescent probes.
Academic Article Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation.
Academic Article ESCargo: a regulatable fluorescent secretory cargo for diverse model organisms.
Academic Article Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome.
Grant PET imaging of a4b2 nicotinic receptor upregulation and smoking cessation
Grant Trafficking of Transporters
Grant Proteomic Assays of Neuronal Protein Palmitoylation
Grant Different components of nicotine-induced upregulation of nicotinic receptors
Grant The Neuronal alpha-bungarotoxin Binding Site
Grant The Neuronal alpha-bungarotoxin Binding Site
Grant Quality Control of Nicotinic Receptor Assembly
Search Criteria
  • Cell Biology
  • Neurons