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Search Results to William Green

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One or more keywords matched the following properties of Green, William

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keywords Trafficking, Protein
overview My research is focused on ionotropic neurotransmitter receptors, the receptors responsible for the rapid postsynaptic response in nerve and muscle. These receptors are large oligomeric membrane proteins with subunits surrounding an ion channel that opens when neurotransmitters bind to the receptor. There are two different families of ionotropic neurotransmitter receptors. One family includes nicotinic acetylcholine receptors (AChRs), GABA and glycine receptors, and the other family are glutamate receptors, both NMDA- and AMPA-type glutamate receptors. The overall goal of my research is to understand how nerve and muscle build these receptors and traffic them specifically to and from synapses. These events regulate the number, density and function of the receptors at synapses, which helps define synaptic strength. The same events underlie learning and memory formation, and when they fail, can contribute to a number of diseases including Alzheimer’s disease, Huntington’s Disease, Myasthenia Gravis and Myasthenic Syndromes. There are several projects ongoing in my lab characterizing the basic cell biology of these receptors, which include receptor assembly, trafficking and clustering. Assembly refers to the processes that transform newly synthesized subunits into functional receptors usually in the endoplasmic reticulum. Trafficking refers to the processes that transport the receptors to and from different location in cells and targets them to these locations. Clustering is the process that packs and maintains the receptors in regions of high density such as synapses. Recently, we have developed new techniques for assaying the protein post-translation modification known as palmitoylation. This work has led to several collaborations in which we are helping to characterize the palmitoylation of a number of different proteins. I also am collaborating with Dr. Paul Selvin (University of Illinois) developing fluorescent single-molecule methods to characterize neurotransmitter receptor subunit composition, stoichiometry and the diffusion/trafficking of these receptors.

One or more keywords matched the following items that are connected to Green, William

Item TypeName
Concept Membrane Proteins
Concept Nerve Tissue Proteins
Concept Heat-Shock Proteins
Concept Muscle Proteins
Concept Protein Binding
Concept Protein Conformation
Concept Protein Processing, Post-Translational
Concept Proteins
Concept Protein Biosynthesis
Concept rho GTP-Binding Proteins
Concept Protein Subunits
Concept Cysteine Proteinase Inhibitors
Concept Protein Structure, Tertiary
Concept Amyloid beta-Protein Precursor
Concept Serotonin Plasma Membrane Transport Proteins
Concept Synaptosomal-Associated Protein 25
Concept Receptor Protein-Tyrosine Kinases
Concept Protein Transport
Concept Protein Folding
Concept Green Fluorescent Proteins
Concept Protein Disulfide-Isomerases
Concept Amphibian Proteins
Concept Recombinant Proteins
Concept Adaptor Proteins, Signal Transducing
Concept GABA Plasma Membrane Transport Proteins
Concept Protein Multimerization
Concept cdc42 GTP-Binding Protein
Concept Mutant Proteins
Concept Amyloid Precursor Protein Secretases
Concept Protein Stability
Concept Carrier Proteins
Concept Luminescent Proteins
Concept Neoplasm Proteins
Concept Nuclear Proteins
Concept Recombinant Fusion Proteins
Concept Cyclic AMP-Dependent Protein Kinases
Concept Protein Isoforms
Academic Article Neuronal alpha-bungarotoxin receptors differ structurally from other nicotinic acetylcholine receptors.
Academic Article The role of the cystine loop in acetylcholine receptor assembly.
Academic Article Ion channel assembly: creating structures that function.
Academic Article Formation of the nicotinic acetylcholine receptor binding sites.
Academic Article alpha-bungarotoxin receptors contain alpha7 subunits in two different disulfide-bonded conformations.
Academic Article Transient expression of heteromeric ion channels.
Academic Article Neuronal alpha-bungarotoxin receptors are alpha7 subunit homomers.
Academic Article A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface.
Academic Article Labeling and quantifying sites of protein palmitoylation.
Academic Article Regulation of nicotinic acetylcholine receptor assembly.
Academic Article N-linked glycosylation is required for nicotinic receptor assembly but not for subunit associations with calnexin.
Academic Article Assays of protein palmitoylation.
Academic Article Regulation of nicotinic receptor expression by the ubiquitin-proteasome system.
Academic Article S-palmitoylation of gamma-secretase subunits nicastrin and APH-1.
Academic Article Ric-3 promotes alpha7 nicotinic receptor assembly and trafficking through the ER subcompartment of dendrites.
Academic Article High affinity binding of epibatidine to serotonin type 3 receptors.
Academic Article Up-regulation of nicotinic receptors by nicotine varies with receptor subtype.
Academic Article Endoplasmic reticulum chaperones stabilize nicotinic receptor subunits and regulate receptor assembly.
Academic Article Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction.
Academic Article Palmitoylation of nicotinic acetylcholine receptors.
Academic Article Nicotinic receptor assembly requires multiple regions throughout the gamma subunit.
Academic Article Rearrangement of nicotinic receptor alpha subunits during formation of the ligand binding sites.
Academic Article The role of palmitoylation in functional expression of nicotinic alpha7 receptors.
Academic Article CASK regulates SAP97 conformation and its interactions with AMPA and NMDA receptors.
Academic Article Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants.
Academic Article SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway.
Academic Article Synaptic SAP97 isoforms regulate AMPA receptor dynamics and access to presynaptic glutamate.
Academic Article Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy.
Academic Article Synaptic activity regulates AMPA receptor trafficking through different recycling pathways.
Academic Article Palmitoylation regulates glutamate receptor distributions in postsynaptic densities through control of PSD95 conformation and orientation.
Academic Article S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects.
Academic Article Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function.
Academic Article Essential roles of the acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning.
Academic Article Acetylcholine receptor assembly: subunit folding and oligomerization occur sequentially.
Academic Article Surface charges near the guanidinium neurotoxin binding site.
Academic Article Small quantum dots conjugated to nanobodies as immunofluorescence probes for nanometric microscopy.
Academic Article Altered palmitoylation and neuropathological deficits in mice lacking HIP14.
Academic Article The 56th Annual Meeting and Symposium of the Society of General Physiologists: trafficking of transporters.
Academic Article cAMP stimulation of acetylcholine receptor expression is mediated through posttranslational mechanisms.
Academic Article Fibroblasts transfected with Torpedo acetylcholine receptor beta-, gamma-, and delta-subunit cDNAs express functional receptors when infected with a retroviral alpha recombinant.
Academic Article Proteomic identification of palmitoylated proteins.
Academic Article Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.
Academic Article Cyclic AMP-regulated AChR assembly is independent of AChR subunit phosphorylation by PKA.
Academic Article Super-resolution imaging of synaptic and Extra-synaptic AMPA receptors with different-sized fluorescent probes.
Academic Article Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation.
Academic Article An alternative translational reading frame encodes an immunodominant retroviral CTL determinant expressed by an immunodeficiency-causing retrovirus.
Academic Article Use of IRF-3 and/or IRF-7 knockout mice to study viral pathogenesis: lessons from a murine retrovirus-induced AIDS model.
Academic Article Cytotoxic activities of monoclonal antibodies against the envelope proteins of murine leukemia virus.
Academic Article Alternative translational reading frames as a novel source of epitopes for an expanded CD8 T-cell repertoire: use of a retroviral system to assess the translational requirements for CTL recognition and lysis.
Academic Article Editorial: Role of Protein Palmitoylation in Synaptic Plasticity and Neuronal Differentiation.

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  • Misfolding