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Search Results to Barbara Lynne Kee

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overview Transcriptional Control of Innate and Adaptive Lymphoid Development and Transformation The execution of an effective immune response with minimal immune-mediated disease requires appropriate control of the development and function of adaptive and innate components of the immune system. B and T lymphocytes are the cells that mediate adaptive immunity; they are highly antigen specific but require substantial expansion and activation prior to promoting an effective immune response. In contrast, natural killer (NK) cells, innate-like T lymphocytes, and the recently identified innate lymphoid cells (ILCs) are lymphocytes that function in innate immunity; they acquire their effector properties during their development and are poised to rapidly confront invading pathogens. All immune system cells develop from a common hematopoietic stem cell (HSC) whose differentiation pathway is controlled in part by the activation and repression of lineage specific gene programs. Our laboratory is interested in understanding how these transcriptional programs are wired and how alterations in these pathways lead to disease such as autoimmunity, asthma and acute leukemia. The E protein class of basic helix-loop-helix (bHLH) transcription factors and their antagonists, the ID proteins, play fundamental roles in the choice between adaptive and innate lymphoid differentiation and they control the precise effector functions exhibited by these cells. Failure to properly control the activity of these proteins leads to immune deficiencies and cancer. The E protein E2A is required for development of B and T lymphocytes due to direct regulation of critical transcriptional networks that specify these lineages from HSCs and multipotent progenitors. Despite a severe T lymphocyte immune deficiency in E2A-deficient mice, the mice develop a disease similar to T lymphocyte acute lymphoblastic leukemia (T-ALL), and the human disease is characterized by recurrent mutations that affect E protein function. We identified a transcriptional cascade involving the transcription factors Notch1 and LEF1 as being critical for leukemia cell survival and we are working toward an understanding of how these transcription factors contribute to both immune deficiency and leukemogenesis. ID2 and ID3 control the development and effector fate of innate lymphoid cells including NK cells, ILCs and NKT cells. Our laboratory has focused on understanding how ID protein expression is regulated in innate lymphoid cells and how the targets of the E protein transcription factors control adaptive and innate lymphoid cell differentiation. Our recent studies led to the identification of ETS1 as a critical regulator of ID2 that promotes NK cell and ILC differentiation, and we are working toward an understanding of how ETS1 and ID2 cooperate to control NK cell maturation and effector function.

One or more keywords matched the following items that are connected to Kee, Barbara Lynne

Item TypeName
Concept Hematopoietic Stem Cells
Concept Stem Cells
Concept Stem Cell Factor
Concept Adult Stem Cells
Concept Multipotent Stem Cells
Concept Myeloid Progenitor Cells
Concept Lymphoid Progenitor Cells
Academic Article Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12.
Academic Article Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-beta.
Academic Article IL-7Ralpha and E47: independent pathways required for development of multipotent lymphoid progenitors.
Academic Article Interferon-producing killer dendritic cells (IKDCs) arise via a unique differentiation pathway from primitive c-kitHiCD62L+ lymphoid progenitors.
Academic Article A s-myly route toward lymphoid differentiation.
Academic Article Id3 induces growth arrest and caspase-2-dependent apoptosis in B lymphocyte progenitors.
Academic Article Hedgehog signaling is dispensable for adult hematopoietic stem cell function.
Academic Article E proteins and the regulation of early lymphocyte development.
Academic Article A comprehensive transcriptional landscape of human hematopoiesis.
Academic Article Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors.
Academic Article E2A proteins promote development of lymphoid-primed multipotent progenitors.
Academic Article Transcriptional regulation of lymphocyte development.
Academic Article In-vitro models of B-lineage commitment.
Academic Article Development of B lymphocytes from lymphoid committed and uncommitted progenitors.
Academic Article Stromal cell independent growth of bipotent B cell--macrophage precursors from murine fetal liver.
Academic Article Murine B cell development: commitment and progression from multipotential progenitors to mature B lymphocytes.
Academic Article In vitro tracking of IL-7 responsiveness and gene expression during commitment of bipotent B-cell/macrophage progenitors.
Academic Article Analysis of immunoglobulin gene rearrangement in fetal B-cell progenitors developing in vivo or in vitro.
Academic Article Histone 3 lysine 4 methylation during the pre-B to immature B-cell transition.
Academic Article Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas.
Academic Article E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment.
Academic Article Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.
Academic Article NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors.
Academic Article Development of innate lymphoid cells.
Academic Article Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1.
Academic Article Cryptic activation of an Irf8 enhancer governs cDC1 fate specification.

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