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One or more keywords matched the following properties of Kee, Barbara Lynne
keywords Natural Killer Cells
keywords Natural Killer T Cells
keywords T Lymphocytes
keywords B Lymphocytes
overview Transcriptional Control of Innate and Adaptive Lymphoid Development and Transformation The execution of an effective immune response with minimal immune-mediated disease requires appropriate control of the development and function of adaptive and innate components of the immune system. B and T lymphocytes are the cells that mediate adaptive immunity; they are highly antigen specific but require substantial expansion and activation prior to promoting an effective immune response. In contrast, natural killer (NK) cells, innate-like T lymphocytes, and the recently identified innate lymphoid cells (ILCs) are lymphocytes that function in innate immunity; they acquire their effector properties during their development and are poised to rapidly confront invading pathogens. All immune system cells develop from a common hematopoietic stem cell (HSC) whose differentiation pathway is controlled in part by the activation and repression of lineage specific gene programs. Our laboratory is interested in understanding how these transcriptional programs are wired and how alterations in these pathways lead to disease such as autoimmunity, asthma and acute leukemia. The E protein class of basic helix-loop-helix (bHLH) transcription factors and their antagonists, the ID proteins, play fundamental roles in the choice between adaptive and innate lymphoid differentiation and they control the precise effector functions exhibited by these cells. Failure to properly control the activity of these proteins leads to immune deficiencies and cancer. The E protein E2A is required for development of B and T lymphocytes due to direct regulation of critical transcriptional networks that specify these lineages from HSCs and multipotent progenitors. Despite a severe T lymphocyte immune deficiency in E2A-deficient mice, the mice develop a disease similar to T lymphocyte acute lymphoblastic leukemia (T-ALL), and the human disease is characterized by recurrent mutations that affect E protein function. We identified a transcriptional cascade involving the transcription factors Notch1 and LEF1 as being critical for leukemia cell survival and we are working toward an understanding of how these transcription factors contribute to both immune deficiency and leukemogenesis. ID2 and ID3 control the development and effector fate of innate lymphoid cells including NK cells, ILCs and NKT cells. Our laboratory has focused on understanding how ID protein expression is regulated in innate lymphoid cells and how the targets of the E protein transcription factors control adaptive and innate lymphoid cell differentiation. Our recent studies led to the identification of ETS1 as a critical regulator of ID2 that promotes NK cell and ILC differentiation, and we are working toward an understanding of how ETS1 and ID2 cooperate to control NK cell maturation and effector function.
One or more keywords matched the following items that are connected to Kee, Barbara Lynne
Item TypeName
Concept Bone Marrow Cells
Concept Antigens, Differentiation, T-Lymphocyte
Concept B-Lymphocytes
Concept Dendritic Cells
Concept Killer Cells, Natural
Concept T-Lymphocytes, Helper-Inducer
Concept Hematopoietic Stem Cells
Concept HeLa Cells
Concept Stem Cells
Concept Langerhans Cells
Concept Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
Concept Tumor Cells, Cultured
Concept Receptors, Antigen, T-Cell, gamma-delta
Concept CD4-Positive T-Lymphocytes
Concept T-Lymphocyte Subsets
Concept CD8-Positive T-Lymphocytes
Concept Th2 Cells
Concept NIH 3T3 Cells
Concept COS Cells
Concept Adult Stem Cells
Concept Multipotent Stem Cells
Concept Natural Killer T-Cells
Concept Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Concept Precursor Cells, B-Lymphoid
Concept Lymphoma, T-Cell
Concept Stromal Cells
Concept Myeloid Progenitor Cells
Concept Lymphoid Progenitor Cells
Concept Th17 Cells
Concept Cells, Cultured
Concept Lymphocytes
Concept Receptors, Antigen, T-Cell
Concept T-Lymphocytes
Concept Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Concept Leukemia, T-Cell
Concept Myeloid Cells
Academic Article Characterization of murine CD10, an endopeptidase expressed on bone marrow adherent cells.
Academic Article Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12.
Academic Article E2A proteins: essential regulators at multiple stages of B-cell development.
Academic Article Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-beta.
Academic Article Transcription factor regulation of B lineage commitment.
Academic Article IL-7Ralpha and E47: independent pathways required for development of multipotent lymphoid progenitors.
Academic Article Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A.
Academic Article Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.
Academic Article Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas.
Academic Article A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining.
Academic Article DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection.
Academic Article Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms.
Academic Article Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity.
Academic Article Extrinsic and intrinsic regulation of early natural killer cell development.
Academic Article Interferon-producing killer dendritic cells (IKDCs) arise via a unique differentiation pathway from primitive c-kitHiCD62L+ lymphoid progenitors.
Academic Article Lymphoid development: it's not 'all Greek to us' any more.
Academic Article A s-myly route toward lymphoid differentiation.
Academic Article Id3 induces growth arrest and caspase-2-dependent apoptosis in B lymphocyte progenitors.
Academic Article Hedgehog signaling is dispensable for adult hematopoietic stem cell function.
Academic Article Helix-loop-helix proteins in lymphocyte lineage determination.
Academic Article Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells.
Academic Article E proteins and the regulation of early lymphocyte development.
Academic Article Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis.
Academic Article differential roles for the E2A activation domains in B lymphocytes and macrophages.
Academic Article Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors.
Academic Article Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2.
Academic Article E2A proteins promote development of lymphoid-primed multipotent progenitors.
Academic Article Transcriptional regulation of lymphocyte development.
Academic Article E and ID proteins branch out.
Academic Article SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics.
Academic Article In-vitro models of B-lineage commitment.
Academic Article Development of B lymphocytes from lymphoid committed and uncommitted progenitors.
Academic Article Stromal cell independent growth of bipotent B cell--macrophage precursors from murine fetal liver.
Academic Article The transcriptional regulation of B cell lineage commitment.
Academic Article Murine B cell development: commitment and progression from multipotential progenitors to mature B lymphocytes.
Academic Article Epidermal Langerhans cells promote skin allograft rejection in mice with NF-kappa B-impaired T cells.
Academic Article Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.
Academic Article The TLX1 oncogene drives aneuploidy in T cell transformation.
Academic Article Gene deregulation and chronic activation in natural killer cells deficient in the transcription factor ETS1.
Academic Article In vitro tracking of IL-7 responsiveness and gene expression during commitment of bipotent B-cell/macrophage progenitors.
Academic Article Analysis of immunoglobulin gene rearrangement in fetal B-cell progenitors developing in vivo or in vitro.
Academic Article Histone 3 lysine 4 methylation during the pre-B to immature B-cell transition.
Academic Article Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas.
Academic Article Multiple hats for natural killers.
Academic Article Early B-cell factor regulates the expression of Hemokinin-1 in the olfactory epithelium and differentiating B lymphocytes.
Academic Article CD10 and CD44 genes of leukemic cells and malignant cell lines show no evidence of transformation-related alterations.
Academic Article Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator.
Academic Article E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment.
Academic Article ID'ing innate and innate-like lymphoid cells.
Academic Article The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation.
Academic Article Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota.
Academic Article Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.
Academic Article Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage.
Academic Article Essential functions for ID proteins at multiple checkpoints in invariant NKT cell development.
Academic Article Sox4 B-lymphocyte progenitors.
Academic Article NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors.
Academic Article Gut Microbiota Regulates K/BxN Autoimmune Arthritis through Follicular Helper T but Not Th17 Cells.
Academic Article The ETS1 transcription factor is required for the development and cytokine-induced expansion of ILC2.
Academic Article Development of innate lymphoid cells.
Academic Article Murine thymic NK cells are distinct from ILC1s and have unique transcription factor requirements.
Academic Article Applying the TOR(C)QUE in iNKT cells: A new twist in an old tale.
Academic Article EZH2 Regulates the Developmental Timing of Effectors of the Pre-Antigen Receptor Checkpoints.
Academic Article Lnc'ing Id2 to ILC1.
Academic Article Transcriptional and epigenetic regulation of innate-like T lymphocyte development.
Academic Article Transcription factor ID2 prevents E proteins from enforcing a naïve T lymphocyte gene program during NK cell development.
Academic Article Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1.
Academic Article Cryptic activation of an Irf8 enhancer governs cDC1 fate specification.
Academic Article Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf.
Academic Article Ezh2 Represses Transcription of Innate Lymphoid Genes in B Lymphocyte Progenitors and Maintains the B-2 Cell Fate.
Academic Article Transcriptional regulation of natural killer cell development and maturation.
Academic Article The transcription factor BCL-6 controls early development of innate-like T cells.
Academic Article Combinatorial ETS1-dependent control of oncogenic NOTCH1 enhancers in T-cell leukemia.
Academic Article It's a Phase That EBF1 Is Going Through.
Academic Article The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.
Academic Article Oncogenic and Tumor Suppressor Functions for Lymphoid Enhancer Factor 1 in E2a-/- T Acute Lymphoblastic Leukemia.
Academic Article E Protein Transcription Factors as Suppressors of T Lymphocyte Acute Lymphoblastic Leukemia.
Academic Article Genomic and Transcriptional Mechanisms Governing Innate-like T Lymphocyte Development.
Concept T-Cell Acute Lymphocytic Leukemia Protein 1
Concept Mucosal-Associated Invariant T Cells
Academic Article Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia.
Academic Article Quantitative control of Ets1 dosage by a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation.
Academic Article TGF-ß Promotes the Postselection Thymic Development and Peripheral Function of IFN-?-Producing Invariant NKT cells.
Academic Article Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T-ALL.
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  • T Cells