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Search Results to Thomas F. Gajewski

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One or more keywords matched the following items that are connected to Gajewski, Thomas F.

Item TypeName
Concept Antigen-Presenting Cells
Concept Bone Marrow Cells
Concept Cell Line, Transformed
Concept Cell Differentiation
Concept Cell Movement
Concept Cell Nucleus
Concept Carcinoma, Renal Cell
Concept Carcinoma, Non-Small-Cell Lung
Concept Cell Membrane
Concept Cell Division
Concept Cell Separation
Concept Clone Cells
Concept Cell-Free System
Concept Cell Cycle
Concept Dendritic Cells
Concept Cell Compartmentation
Concept Killer Cells, Natural
Concept Neoplastic Cells, Circulating
Concept Receptors, Antigen, B-Cell
Concept CHO Cells
Concept Adenocarcinoma, Clear Cell
Concept Hematopoietic Stem Cell Transplantation
Concept Th1 Cells
Concept Cell Culture Techniques
Concept Tumor Cells, Cultured
Concept Cell Adhesion Molecules
Concept PC12 Cells
Concept Receptors, Antigen, T-Cell, gamma-delta
Concept T-Cell Antigen Receptor Specificity
Concept Receptors, Antigen, T-Cell, alpha-beta
Concept Cell Transplantation
Concept Cell Proliferation
Concept Th2 Cells
Concept Hematopoietic Stem Cell Mobilization
Concept Calcium Signaling
Concept Jurkat Cells
Concept Intercellular Signaling Peptides and Proteins
Concept Programmed Cell Death 1 Ligand 2 Protein
Concept Cell Cycle Proteins
Concept Active Transport, Cell Nucleus
Concept Red-Cell Aplasia, Pure
Concept Adaptor Proteins, Signal Transducing
Concept Lymphoma, B-Cell
Concept Cell Polarity
Concept Stromal Cells
Concept Cell Lineage
Concept MAP Kinase Signaling System
Concept Extracellular Signal-Regulated MAP Kinases
Concept Programmed Cell Death 1 Receptor
Concept Cell Line, Tumor
Concept Wnt Signaling Pathway
Concept Cell Line
Concept Cell Survival
Concept Cells, Cultured
Concept Receptors, Antigen, T-Cell
Concept Mast-Cell Sarcoma
Concept Signal Transduction
Concept Myeloid Cells
Concept CARD Signaling Adaptor Proteins
Academic Article Differential regulation of murine T lymphocyte subsets.
Academic Article Differential function of intestinal intraepithelial lymphocyte subsets.
Academic Article B7-1 but not B7-2 efficiently costimulates CD8+ T lymphocytes in the P815 tumor system in vitro.
Academic Article Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization.
Academic Article Liver of MRL/lpr mice contain interleukin-4-producing lymphocytes and accessory cells that support the proliferation of Th2 helper T lymphocyte clones.
Academic Article Induction of a cytolytic T-cell response in mice with a recombinant adenovirus coding for tumor antigen P815A.
Academic Article Endogenous IL-12 is necessary for rejection of P815 tumor variants in vivo.
Academic Article Antigen-specific regression of established tumors induced by active immunization with irradiated IL-12- but not B7-1-transfected tumor cells.
Academic Article Antigen recognition and allogeneic tumor rejection in CD8+ TCR transgenic/RAG(-/-) mice.
Academic Article Apoptosis meets signal transduction: elimination of a BAD influence.
Academic Article The expression of mouse gene P1A in testis does not prevent safe induction of cytolytic T cells against a P1A-encoded tumor antigen.
Academic Article Blocked Ras activation in anergic CD4+ T cells.
Academic Article Rational development of tumour antigen-specific immunization in melanoma.
Academic Article Interleukin-12-secreting human papillomavirus type 16-transformed cells provide a potent cancer vaccine that generates E7-directed immunity.
Academic Article B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28.
Academic Article Allogeneic peripheral blood stem cell transplantation for metastatic renal cell carcinoma.
Academic Article Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells.
Academic Article Cutting edge: differentiation of antitumor CTL in vivo requires host expression of Stat1.
Academic Article Monitoring specific T-cell responses to melanoma vaccines: ELISPOT, tetramers, and beyond.
Academic Article Biochemical analysis of activated T lymphocytes. Protein phosphorylation and Ras, ERK, and JNK activation.
Academic Article Helper T cell differentiation is controlled by the cell cycle.
Academic Article B7.1 is a quantitatively stronger costimulus than B7.2 in the activation of naive CD8+ TCR-transgenic T cells.
Academic Article Antigen-specific blockade of T cells in vivo using dimeric MHC peptide.
Academic Article CD28 is not required for c-Jun N-terminal kinase activation in T cells.
Academic Article Improved efficacy of dendritic cell vaccines and successful immunization with tumor antigen peptide-pulsed peripheral blood mononuclear cells by coadministration of recombinant murine interleukin-12.
Academic Article Allogeneic stem-cell transplantation of renal cell cancer after nonmyeloablative chemotherapy: feasibility, engraftment, and clinical results.
Academic Article Flt-3 ligand and sequential FL/interleukin-2 in patients with metastatic renal carcinoma: clinical and biologic activity.
Academic Article Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).
Academic Article Transplantation and the CD28/CTLA4/B7 pathway.
Academic Article Immunization of HLA-A2+ melanoma patients with MAGE-3 or MelanA peptide-pulsed autologous peripheral blood mononuclear cells plus recombinant human interleukin 12.
Academic Article Cutting edge: spontaneous rejection of poorly immunogenic P1.HTR tumors by Stat6-deficient mice.
Academic Article Differential activation of murine TH1 and TH2 clones.
Academic Article Immunization with Melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanoma.
Academic Article B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism.
Academic Article T cell development and function in CrkL-deficient mice.
Academic Article Death of peripheral CD8+ T cells in the absence of MHC class I is Fas-dependent and not blocked by Bcl-xL.
Academic Article Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase.
Academic Article Epitope spreading upon P815 tumor rejection triggered by vaccination with the single class I MHC-restricted peptide P1A.
Academic Article Clinical responses following nonmyeloablative allogeneic stem cell transplantation for renal cell carcinoma are associated with expansion of CD8+ IFN-gamma-producing T cells.
Academic Article Differential Ras signaling via the antigen receptor and IL-2 receptor in primary T lymphocytes.
Academic Article Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.
Academic Article Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration.
Academic Article Depletion of normal B cells with rituximab as an adjunct to IL-2 therapy for renal cell carcinoma and melanoma.
Academic Article Long-term follow-up of nonmyeloablative allogeneic stem cell transplantation for renal cell carcinoma: The University of Chicago Experience.
Academic Article Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy.
Academic Article Gene array and protein expression profiles suggest post-transcriptional regulation during CD8+ T cell differentiation.
Academic Article CD4+ murine T cell clones that express high levels of immunoglobulin binding belong to the interleukin 4-producing T helper cell type 2 subset.
Academic Article Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.
Academic Article Disparate functions of immature and mature human myeloid dendritic cells: implications for dendritic cell-based vaccines.
Academic Article Absence of programmed death receptor 1 alters thymic development and enhances generation of CD4/CD8 double-negative TCR-transgenic T cells.
Academic Article Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro.
Academic Article Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones.
Academic Article Cutting edge: cytotoxic granule polarization and cytolysis can occur without central supramolecular activation cluster formation in CD8+ effector T cells.
Academic Article Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection.
Academic Article Tumor progression despite massive influx of activated CD8(+) T cells in a patient with malignant melanoma ascites.
Academic Article Molecular regulation of T-cell anergy.
Academic Article The p815 mastocytoma tumor model.
Academic Article Production of TH1 and TH2 cell lines and clones.
Academic Article Diagnosis and treatment of mycoplasma-contaminated cell cultures.
Academic Article Diagnosis and treatment of Mycoplasma-contaminated cell cultures.
Academic Article Homeostatic proliferation plus regulatory T-cell depletion promotes potent rejection of B16 melanoma.
Academic Article Melanoma presenting as circulating tumor cells associated with failed angiogenesis.
Academic Article Failure at the effector phase: immune barriers at the level of the melanoma tumor microenvironment.
Academic Article Diagnosis and treatment of mycoplasma-contaminated cell cultures.
Academic Article Metabolic mechanisms of tumor resistance to T cell effector function.
Academic Article Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment.
Academic Article Negative regulation of T-cell function by PD-1.
Academic Article Peripheral survival of naïve CD8+ T cells.
Academic Article Protein kinase Ctheta focusing at the cSMAC is a consequence rather than cause of TCR signaling and is dependent on the MEK/ERK pathway.
Academic Article Anti-proliferative effect of IFN-gamma in immune regulation. IV. Murine CTL clones produce IL-3 and GM-CSF, the activity of which is masked by the inhibitory action of secreted IFN-gamma.
Academic Article A randomized phase II trial of interleukin-2 in combination with four different doses of bryostatin-1 in patients with renal cell carcinoma.
Academic Article Induction of cytotoxic granules in human memory CD8+ T cell subsets requires cell cycle progression.
Academic Article T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha.
Academic Article Cross-priming of T cells to intracranial tumor antigens elicits an immune response that fails in the effector phase but can be augmented with local immunotherapy.
Academic Article Phenotypic and functional analysis of murine CD3+,CD4-,CD8- TCR-gamma delta-expressing peripheral T cells.
Academic Article Homeostatic proliferation of naïve CD8+ T cells depends on CD62L/L-selectin-mediated homing to peripheral LN.
Academic Article Improved melanoma survival at last! Ipilimumab and a paradigm shift for immunotherapy.
Academic Article Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells.
Academic Article Emerging strategies in regulatory T-cell immunotherapies.
Academic Article Costimulatory and coinhibitory receptors in anti-tumor immunity.
Academic Article Use of Cre-adenovirus and CAR transgenic mice for efficient deletion of genes in post-thymic T cells.
Academic Article Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4+ T cells.
Academic Article Innate immune sensing of cancer: clues from an identified role for type I IFNs.
Academic Article A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library.
Academic Article Nakahara memorial lecture. Regulation of T lymphocyte responses: interactions among receptors.
Academic Article ICAM-1 contributes to but is not essential for tumor antigen cross-priming and CD8+ T cell-mediated tumor rejection in vivo.
Academic Article Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells.
Academic Article Evidence implicating I region-restricted antigen presentation in alloantigen and nominal antigen recognition by a dual-reactive helper T lymphocyte clone.
Academic Article Murine hepatic accessory cells support the proliferation of Th1 but not Th2 helper T lymphocyte clones.
Academic Article Regulation of T-cell activation: differences among T-cell subsets.
Academic Article An adenoviral vector for probing promoter activity in primary immune cells.
Academic Article Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo.
Academic Article Costimulation with B7-1, IL-6, and IL-12 is sufficient for primary generation of murine antitumor cytolytic T lymphocytes in vitro.
Academic Article Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.
Academic Article Clinical development of mAbs to block the PD1 pathway as an immunotherapy for cancer.
Academic Article Differential activation of Th1 and Th2 CD4+ cells by murine brain microvessel endothelial cells and smooth muscle/pericytes.
Academic Article Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells.
Academic Article Induction of the increased Fyn kinase activity in anergic T helper type 1 clones requires calcium and protein synthesis and is sensitive to cyclosporin A.
Academic Article Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen-specific T lymphocyte clones through the TCR or Thy-1.
Academic Article Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways.
Academic Article Targeting the primary tumor to generate CTL for the effective eradication of spontaneous metastases.
Academic Article The expanding universe of regulatory T cell subsets in cancer.
Academic Article An adenoviral vector encoding dominant negative Cbl lowers the threshold for T cell activation in post-thymic T cells.
Academic Article "Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.
Academic Article CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells.
Academic Article Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-?1 phosphorylation.
Academic Article Cellular and molecular requirements for rejection of B16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation.
Academic Article Anti-proliferative effect of IFN-gamma in immune regulation. II. IFN-gamma inhibits the proliferation of murine bone marrow cells stimulated with IL-3, IL-4, or granulocyte-macrophage colony-stimulating factor.
Academic Article Interleukin 2 and concanavalin A stimulate interferon-gamma production in a murine cytolytic T cell clone by different pathways.
Academic Article Control of T lymphocyte signal transduction through clonal anergy.
Academic Article A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3.
Academic Article Expression and function of CTLA-4 in Th1 and Th2 cells.
Academic Article Regulation of anti-immunoglobulin-induced B lymphoma growth arrest by transforming growth factor beta 1 and dexamethasone.
Academic Article Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells.
Academic Article A phase II study of bryostatin-1 and paclitaxel in patients with advanced non-small cell lung cancer.
Academic Article PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells.
Academic Article Formation of a central supramolecular activation cluster is not required for activation of naive CD8+ T cells.
Academic Article Overcoming immune resistance in the tumor microenvironment by blockade of indoleamine 2,3-dioxygenase and programmed death ligand 1.
Academic Article Lymphoma-infiltrating immune cells.
Academic Article Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level.
Academic Article Immune-mediated red cell aplasia after anti-CTLA-4 immunotherapy for metastatic melanoma.
Academic Article PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model.
Academic Article Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.
Academic Article Beta-catenin does not regulate memory T cell phenotype.
Academic Article Phase II study of immunomodulation with granulocyte-macrophage colony-stimulating factor, interleukin-2, and rituximab following autologous stem cell transplant in patients with relapsed or refractory lymphomas.
Academic Article Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment.
Academic Article CD40 ligation reverses T cell tolerance in acute myeloid leukemia.
Academic Article Type I interferon response and innate immune sensing of cancer.
Academic Article Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104).
Academic Article Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy.
Academic Article Targeting the tumor microenvironment with interferon-ß bridges innate and adaptive immune responses.
Academic Article Therapeutic activity of high-dose intratumoral IFN-ß requires direct effect on the tumor vasculature.
Academic Article Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction.
Academic Article STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.
Academic Article New perspectives on type I IFNs in cancer.
Academic Article Primary murine CD4+ T cells fail to acquire the ability to produce effector cytokines when active Ras is present during Th1/Th2 differentiation.
Academic Article STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Academic Article Innate immune recognition of cancer.
Academic Article Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells.
Academic Article T cell-NF-?B activation is required for tumor control in vivo.
Academic Article Innate and adaptive immune cells in the tumor microenvironment.
Academic Article Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment.
Academic Article Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.
Academic Article The STING pathway and the T cell-inflamed tumor microenvironment.
Academic Article Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints.
Academic Article Melanoma-intrinsic ß-catenin signalling prevents anti-tumour immunity.
Academic Article The Next Hurdle in Cancer Immunotherapy: Overcoming the Non-T-Cell-Inflamed Tumor Microenvironment.
Academic Article Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer.
Academic Article Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
Academic Article Endogenous and pharmacologic targeting of the STING pathway in cancer immunotherapy.
Academic Article Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy.
Academic Article Cutting Edge: Engineering Active IKKß in T Cells Drives Tumor Rejection.
Academic Article Tumor and Host Factors Controlling Antitumor Immunity and Efficacy of Cancer Immunotherapy.
Academic Article Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA.
Academic Article MYC - a thorn in the side of cancer immunity.
Academic Article Single dose denileukin diftitox does not enhance vaccine-induced T cell responses or effectively deplete Tregs in advanced melanoma: immune monitoring and clinical results of a randomized phase II trial.
Academic Article Molecular Drivers of the Non-T-cell-Inflamed Tumor Microenvironment in Urothelial Bladder Cancer.
Academic Article The composition of the microbiota modulates allograft rejection.
Academic Article The host STING pathway at the interface of cancer and immunity.
Academic Article NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming through PD-1/PD-L1 Interactions with Dendritic Cells.
Academic Article Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanoma.
Academic Article Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.
Academic Article Innate immune signaling and regulation in cancer immunotherapy.
Academic Article The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment.
Academic Article Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy.
Academic Article Impact of oncogenic pathways on evasion of antitumour immune responses.
Academic Article The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients.
Academic Article Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab.
Academic Article Improving Efficacy and Safety of Agonistic Anti-CD40 Antibody Through Extracellular Matrix Affinity.
Academic Article Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy.
Academic Article Intratumoral CD8+ T-cell Apoptosis Is a Major Component of T-cell Dysfunction and Impedes Antitumor Immunity.
Academic Article Pseudoprogression manifesting as recurrent ascites with anti-PD-1 immunotherapy in urothelial bladder cancer.
Academic Article Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy.
Academic Article Distinct Graft-Specific TCR Avidity Profiles during Acute Rejection and Tolerance.
Academic Article Cancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment.
Academic Article WNT/ß-catenin Pathway Activation Correlates with Immune Exclusion across Human Cancers.
Academic Article Major pathologic response on biopsy (MPRbx) in patients with advanced melanoma treated with anti-PD-1: evidence for an early, on-therapy biomarker of response.
Academic Article STING pathway agonism as a cancer therapeutic.
Academic Article Secondary resistance to immunotherapy associated with ß-catenin pathway activation or PTEN loss in metastatic melanoma.
Academic Article Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-?-signaling mutant cancer cells.
Academic Article Strategies to overcome resistance to PD-1 inhibitors.
Academic Article cDC1 dysregulation in cancer: An opportunity for intervention.
Academic Article Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion.

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