The University of Chicago Header Logo

Search Result Details

Back to Search Results
This page shows the details of why an item matched the keywords from your search.
Search Results
Gajewski, Thomas F.
One or more keywords matched the following items that are connected to Gajewski, Thomas F.
Item TypeName
Concept Mice, Inbred C3H
Concept Mice, Inbred A
Concept Mice, Inbred Strains
Concept Mice, Inbred CBA
Concept Mice, Transgenic
Concept Mice, Inbred BALB C
Concept Mice, Inbred C57BL
Concept Mice, Nude
Concept Mice, Inbred DBA
Concept Mice, Knockout
Concept Mice
Concept Mice, Mutant Strains
Academic Article Differential regulation of murine T lymphocyte subsets.
Academic Article Differential function of intestinal intraepithelial lymphocyte subsets.
Academic Article B7-1 but not B7-2 efficiently costimulates CD8+ T lymphocytes in the P815 tumor system in vitro.
Academic Article Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization.
Academic Article Liver of MRL/lpr mice contain interleukin-4-producing lymphocytes and accessory cells that support the proliferation of Th2 helper T lymphocyte clones.
Academic Article Induction of a cytolytic T-cell response in mice with a recombinant adenovirus coding for tumor antigen P815A.
Academic Article Endogenous IL-12 is necessary for rejection of P815 tumor variants in vivo.
Academic Article Antigen-specific regression of established tumors induced by active immunization with irradiated IL-12- but not B7-1-transfected tumor cells.
Academic Article Antigen recognition and allogeneic tumor rejection in CD8+ TCR transgenic/RAG(-/-) mice.
Academic Article The expression of mouse gene P1A in testis does not prevent safe induction of cytolytic T cells against a P1A-encoded tumor antigen.
Academic Article Blocked Ras activation in anergic CD4+ T cells.
Academic Article The immune system as anti-tumor sentinel: molecular requirements for an anti-tumor immune response.
Academic Article Interleukin-12-secreting human papillomavirus type 16-transformed cells provide a potent cancer vaccine that generates E7-directed immunity.
Academic Article B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28.
Academic Article Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells.
Academic Article Cutting edge: differentiation of antitumor CTL in vivo requires host expression of Stat1.
Academic Article Helper T cell differentiation is controlled by the cell cycle.
Academic Article B7.1 is a quantitatively stronger costimulus than B7.2 in the activation of naive CD8+ TCR-transgenic T cells.
Academic Article Antigen-specific blockade of T cells in vivo using dimeric MHC peptide.
Academic Article CD28 is not required for c-Jun N-terminal kinase activation in T cells.
Academic Article Improved efficacy of dendritic cell vaccines and successful immunization with tumor antigen peptide-pulsed peripheral blood mononuclear cells by coadministration of recombinant murine interleukin-12.
Academic Article Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).
Academic Article Transplantation and the CD28/CTLA4/B7 pathway.
Academic Article Cutting edge: spontaneous rejection of poorly immunogenic P1.HTR tumors by Stat6-deficient mice.
Academic Article Differential activation of murine TH1 and TH2 clones.
Academic Article B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism.
Academic Article T cell development and function in CrkL-deficient mice.
Academic Article Death of peripheral CD8+ T cells in the absence of MHC class I is Fas-dependent and not blocked by Bcl-xL.
Academic Article Integrating IL-12 into therapeutic cancer vaccines.
Academic Article Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase.
Academic Article Epitope spreading upon P815 tumor rejection triggered by vaccination with the single class I MHC-restricted peptide P1A.
Academic Article Differential Ras signaling via the antigen receptor and IL-2 receptor in primary T lymphocytes.
Academic Article Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.
Academic Article Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration.
Academic Article Gene array and protein expression profiles suggest post-transcriptional regulation during CD8+ T cell differentiation.
Academic Article CD4+ murine T cell clones that express high levels of immunoglobulin binding belong to the interleukin 4-producing T helper cell type 2 subset.
Academic Article Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.
Academic Article Absence of programmed death receptor 1 alters thymic development and enhances generation of CD4/CD8 double-negative TCR-transgenic T cells.
Academic Article On the TRAIL toward death receptor-based cancer therapeutics.
Academic Article Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones.
Academic Article Cutting edge: cytotoxic granule polarization and cytolysis can occur without central supramolecular activation cluster formation in CD8+ effector T cells.
Academic Article Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection.
Academic Article Immune suppression in the tumor microenvironment.
Academic Article The p815 mastocytoma tumor model.
Academic Article Production of TH1 and TH2 cell lines and clones.
Academic Article Homeostatic proliferation plus regulatory T-cell depletion promotes potent rejection of B16 melanoma.
Academic Article Melanoma presenting as circulating tumor cells associated with failed angiogenesis.
Academic Article Negative regulation of T-cell function by PD-1.
Academic Article Protein kinase Ctheta focusing at the cSMAC is a consequence rather than cause of TCR signaling and is dependent on the MEK/ERK pathway.
Academic Article Anti-proliferative effect of IFN-gamma in immune regulation. IV. Murine CTL clones produce IL-3 and GM-CSF, the activity of which is masked by the inhibitory action of secreted IFN-gamma.
Academic Article T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha.
Academic Article Cross-priming of T cells to intracranial tumor antigens elicits an immune response that fails in the effector phase but can be augmented with local immunotherapy.
Academic Article Phenotypic and functional analysis of murine CD3+,CD4-,CD8- TCR-gamma delta-expressing peripheral T cells.
Academic Article Homeostatic proliferation of naïve CD8+ T cells depends on CD62L/L-selectin-mediated homing to peripheral LN.
Academic Article Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells.
Academic Article Use of Cre-adenovirus and CAR transgenic mice for efficient deletion of genes in post-thymic T cells.
Academic Article Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4+ T cells.
Academic Article Innate immune sensing of cancer: clues from an identified role for type I IFNs.
Academic Article Future perspectives in melanoma research. Meeting report from the "Melanoma research: a bridge from Naples to the World. Napoli, December 5th-6th 2011".
Academic Article Workshop on immunotherapy combinations. Society for Immunotherapy of Cancer annual meeting Bethesda, November 3, 2011.
Academic Article Nakahara memorial lecture. Regulation of T lymphocyte responses: interactions among receptors.
Academic Article ICAM-1 contributes to but is not essential for tumor antigen cross-priming and CD8+ T cell-mediated tumor rejection in vivo.
Academic Article Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells.
Academic Article Evidence implicating I region-restricted antigen presentation in alloantigen and nominal antigen recognition by a dual-reactive helper T lymphocyte clone.
Academic Article Murine hepatic accessory cells support the proliferation of Th1 but not Th2 helper T lymphocyte clones.
Academic Article An adenoviral vector for probing promoter activity in primary immune cells.
Academic Article Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo.
Academic Article Costimulation with B7-1, IL-6, and IL-12 is sufficient for primary generation of murine antitumor cytolytic T lymphocytes in vitro.
Academic Article Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.
Academic Article Clinical development of mAbs to block the PD1 pathway as an immunotherapy for cancer.
Academic Article Differential activation of Th1 and Th2 CD4+ cells by murine brain microvessel endothelial cells and smooth muscle/pericytes.
Academic Article Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells.
Academic Article Induction of the increased Fyn kinase activity in anergic T helper type 1 clones requires calcium and protein synthesis and is sensitive to cyclosporin A.
Academic Article Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen-specific T lymphocyte clones through the TCR or Thy-1.
Academic Article Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways.
Academic Article Targeting the primary tumor to generate CTL for the effective eradication of spontaneous metastases.
Academic Article An adenoviral vector encoding dominant negative Cbl lowers the threshold for T cell activation in post-thymic T cells.
Academic Article "Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.
Academic Article CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells.
Academic Article Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-?1 phosphorylation.
Academic Article Cellular and molecular requirements for rejection of B16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation.
Academic Article Anti-proliferative effect of IFN-gamma in immune regulation. II. IFN-gamma inhibits the proliferation of murine bone marrow cells stimulated with IL-3, IL-4, or granulocyte-macrophage colony-stimulating factor.
Academic Article Interleukin 2 and concanavalin A stimulate interferon-gamma production in a murine cytolytic T cell clone by different pathways.
Academic Article Expression and function of CTLA-4 in Th1 and Th2 cells.
Academic Article Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells.
Academic Article PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells.
Academic Article Formation of a central supramolecular activation cluster is not required for activation of naive CD8+ T cells.
Academic Article PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model.
Academic Article Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.
Academic Article Beta-catenin does not regulate memory T cell phenotype.
Academic Article CD40 ligation reverses T cell tolerance in acute myeloid leukemia.
Academic Article Type I interferon response and innate immune sensing of cancer.
Academic Article Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy.
Academic Article Targeting the tumor microenvironment with interferon-ß bridges innate and adaptive immune responses.
Academic Article Therapeutic activity of high-dose intratumoral IFN-ß requires direct effect on the tumor vasculature.
Academic Article Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction.
Academic Article STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.
Academic Article New perspectives on type I IFNs in cancer.
Academic Article Primary murine CD4+ T cells fail to acquire the ability to produce effector cytokines when active Ras is present during Th1/Th2 differentiation.
Academic Article STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Academic Article Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells.
Academic Article Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.
Academic Article Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints.
Academic Article Melanoma-intrinsic ß-catenin signalling prevents anti-tumour immunity.
Academic Article Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
Academic Article Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy.
Academic Article Cutting Edge: Engineering Active IKKß in T Cells Drives Tumor Rejection.
Academic Article Tumor and Host Factors Controlling Antitumor Immunity and Efficacy of Cancer Immunotherapy.
Academic Article Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA.
Academic Article The composition of the microbiota modulates allograft rejection.
Academic Article The host STING pathway at the interface of cancer and immunity.
Academic Article NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming through PD-1/PD-L1 Interactions with Dendritic Cells.
Academic Article Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
Academic Article The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment.
Academic Article Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy.
Academic Article The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients.
Academic Article Improving Efficacy and Safety of Agonistic Anti-CD40 Antibody Through Extracellular Matrix Affinity.
Academic Article Intratumoral CD8+ T-cell Apoptosis Is a Major Component of T-cell Dysfunction and Impedes Antitumor Immunity.
Academic Article Distinct Graft-Specific TCR Avidity Profiles during Acute Rejection and Tolerance.
Academic Article Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-?-signaling mutant cancer cells.
Academic Article Exploring the emerging role of the microbiome in cancer immunotherapy.
Academic Article Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion.
Academic Article Cancer and the Microbiome-Influence of the Commensal Microbiota on Cancer, Immune Responses, and Immunotherapy.
Academic Article Lymphatic coagulation and neutrophil extracellular traps in lung-draining lymph nodes of COVID-19 decedents.
Academic Article Batf3+ DCs and the 4-1BB/4-1BBL axis are required at the effector phase in the tumor microenvironment for PD-1/PD-L1 blockade efficacy.
Academic Article Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy.
Search Criteria
  • Laboratory Mice