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Search Results to Ivan Moskowitz

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One or more keywords matched the following properties of Moskowitz, Ivan

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keywords Developmental Biology
keywords Developmental Gene Expression Regulation
keywords Heart Development
overview The Moskowitz laboratory is devoted to the genetic, genomic and molecular study of gene regulatory networks. A single overarching theme governs work in the Moskowitz laboratory: that understanding essential gene regulatory networks will unveil the molecular logic governing biological processes, and that understanding network disruption will inform the molecular basis underlying disease. We have recently pioneered approaches to identify non-coding RNAs as markers and modulators of enhancer function (Yang and Nadadur et al, 2017). The Moskowitz laboratory has focused on two areas of cardiac biology: (1) cardiac conduction with respect to cardiac arrhythmias and (2) cardiac development with respect to Congenital Heart Disease (CHD). In cardiac development, we investigate the genetic, genomic and developmental landscape of cardiac morphogenesis. We have identified an essential role for Hedgehog signaling in the cardiac development and congenital heart disease and contributed to a paradigm shift in the understanding of cardiac septation (e.g. Hoffmann et al., 2009; Xie et al., 2012; Zhou et al., 2017). We have recently identified a surprising and novel role for Hedgehog signaling in maintaining cardiac progenitor status and preventing premature differentiation (Rowton et al., 2018). In cardiac rhythm, we investigate the molecular mechanisms underlying the genetic basis of cardiac arrhythmias. We have defined the first molecular networks and linking GWAS loci in cardiac conduction (Arnolds et al, 2012), the first molecular network in Atrial Fibrillation, the most common arrhythmia world-wide (Nadadur et al., 2016) and the functional genomic mechanisms underlying genetic associations (Van den Boogaard et al., 2014).

One or more keywords matched the following items that are connected to Moskowitz, Ivan

Item TypeName
Concept Embryonic and Fetal Development
Concept Gene Expression Regulation, Developmental
Concept Embryonic Development
Academic Article lin-12 and glp-1 are required zygotically for early embryonic cellular interactions and are regulated by maternal GLP-1 signaling in Caenorhabditis elegans.
Academic Article Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice.
Academic Article The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system.
Academic Article Electrophysiologic characterization and postnatal development of ventricular pre-excitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White syndrome.
Academic Article A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.
Academic Article The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.
Academic Article A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines.
Academic Article Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.
Academic Article Combinatorial specification of blastomere identity by glp-1-dependent cellular interactions in the nematode Caenorhabditis elegans.
Academic Article E2F3 plays an essential role in cardiac development and function.
Academic Article Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected]
Academic Article sonic hedgehog is required in pulmonary endoderm for atrial septation.
Academic Article DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.
Academic Article The emerging genetic landscape underlying cardiac conduction system function.
Academic Article The potential to differentiate epidermis is unequally distributed in the AB lineage during early embryonic development in C. elegans.
Academic Article Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.
Academic Article Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis.
Academic Article Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.
Academic Article Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.
Academic Article The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.
Academic Article TBX5: A Key Regulator of Heart Development.
Academic Article Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development.
Academic Article Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development.
Academic Article Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types.
Academic Article Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation.

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  • Development