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One or more keywords matched the following properties of Moskowitz, Ivan
keywords Developmental Biology
keywords Developmental Gene Expression Regulation
overview The Moskowitz laboratory is devoted to the genetic, genomic and molecular study of gene regulatory networks. A single overarching theme governs work in the Moskowitz laboratory: that understanding essential gene regulatory networks will unveil the molecular logic governing biological processes, and that understanding network disruption will inform the molecular basis underlying disease. We have recently pioneered approaches to identify non-coding RNAs as markers and modulators of enhancer function (Yang and Nadadur et al, 2017). The Moskowitz laboratory has focused on two areas of cardiac biology: (1) cardiac conduction with respect to cardiac arrhythmias and (2) cardiac development with respect to Congenital Heart Disease (CHD). In cardiac development, we investigate the genetic, genomic and developmental landscape of cardiac morphogenesis. We have identified an essential role for Hedgehog signaling in the cardiac development and congenital heart disease and contributed to a paradigm shift in the understanding of cardiac septation (e.g. Hoffmann et al., 2009; Xie et al., 2012; Zhou et al., 2017). We have recently identified a surprising and novel role for Hedgehog signaling in maintaining cardiac progenitor status and preventing premature differentiation (Rowton et al., 2018). In cardiac rhythm, we investigate the molecular mechanisms underlying the genetic basis of cardiac arrhythmias. We have defined the first molecular networks and linking GWAS loci in cardiac conduction (Arnolds et al, 2012), the first molecular network in Atrial Fibrillation, the most common arrhythmia world-wide (Nadadur et al., 2016) and the functional genomic mechanisms underlying genetic associations (Van den Boogaard et al., 2014).
One or more keywords matched the following items that are connected to Moskowitz, Ivan
Item TypeName
Concept Aortic Coarctation
Concept Aortic Valve Stenosis
Concept Arrhythmias, Cardiac
Concept Abnormalities, Multiple
Concept Cardiomyopathy, Hypertrophic
Concept Cleft Lip
Concept Atrial Fibrillation
Concept Bradycardia
Concept Cardiomyopathy, Dilated
Concept Cell Transformation, Neoplastic
Concept Chromosome Deletion
Concept Cleft Palate
Concept Cardiovascular Diseases
Concept Coronary Artery Disease
Concept Down Syndrome
Concept Ductus Arteriosus, Patent
Concept Cardiomegaly
Concept Electrocardiography
Concept Glycogen Storage Disease
Concept Heart Diseases
Concept Heart Failure
Concept Heart Septal Defects, Atrial
Concept Hypertrophy
Concept Purpura, Thrombocytopenic
Concept Myocardial Contraction
Concept Mediastinal Neoplasms
Concept Fibrosis
Concept Pre-Excitation Syndromes
Concept Tetralogy of Fallot
Concept Poliomyelitis
Concept Genetic Markers
Concept Heart Defects, Congenital
Concept Heart Septal Defects, Ventricular
Concept Wolff-Parkinson-White Syndrome
Concept Trisomy
Concept Ventricular Fibrillation
Concept Lymphoma
Concept Lower Extremity Deformities, Congenital
Concept Limb Deformities, Congenital
Concept Cardiomyopathies
Concept Myocarditis
Concept Hypertrophy, Left Ventricular
Concept Common Variable Immunodeficiency
Concept Sequence Deletion
Concept Gene Expression Regulation, Developmental
Concept Ventricular Dysfunction
Concept Cardiomyopathy, Hypertrophic, Familial
Concept Fatal Outcome
Concept Progeria
Concept Postoperative Complications
Concept Brugada Syndrome
Concept Death, Sudden, Cardiac
Concept Ventricular Outflow Obstruction
Concept Stroke
Concept Ventricular Dysfunction, Left
Concept Haploinsufficiency
Concept Upper Extremity Deformities, Congenital
Concept Brain Ischemia
Concept Conversion Disorder
Concept Disease Models, Animal
Concept Heart Rate
Concept Heart Septal Defects
Concept Heart Valve Diseases
Concept Hydrocephalus
Concept Hysteria
Concept Mutagenesis, Insertional
Academic Article lin-12 and glp-1 are required zygotically for early embryonic cellular interactions and are regulated by maternal GLP-1 signaling in Caenorhabditis elegans.
Academic Article Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice.
Academic Article A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.
Academic Article Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.
Academic Article DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.
Academic Article The emerging genetic landscape underlying cardiac conduction system function.
Academic Article Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.
Academic Article Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.
Academic Article Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.
Academic Article The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.
Academic Article Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types.
Academic Article Transcriptional Patterning of the Ventricular Cardiac Conduction System.
Academic Article Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation.
Academic Article Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development.
Concept Atrial Remodeling
Grant Genetic and Molecular Analysis of Congenital Heart Disease
Grant Gene Expression Networks for Human Cardiac Differentiation in Down Syndrome
Grant Etiology of Congenital Heart Disease in Down Syndrome
Academic Article ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment.
Academic Article An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract.
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  • Developmental
  • Disorders