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Search Results to Ivan Moskowitz

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overview The Moskowitz laboratory is devoted to the genetic, genomic and molecular study of gene regulatory networks. A single overarching theme governs work in the Moskowitz laboratory: that understanding essential gene regulatory networks will unveil the molecular logic governing biological processes, and that understanding network disruption will inform the molecular basis underlying disease. We have recently pioneered approaches to identify non-coding RNAs as markers and modulators of enhancer function (Yang and Nadadur et al, 2017). The Moskowitz laboratory has focused on two areas of cardiac biology: (1) cardiac conduction with respect to cardiac arrhythmias and (2) cardiac development with respect to Congenital Heart Disease (CHD). In cardiac development, we investigate the genetic, genomic and developmental landscape of cardiac morphogenesis. We have identified an essential role for Hedgehog signaling in the cardiac development and congenital heart disease and contributed to a paradigm shift in the understanding of cardiac septation (e.g. Hoffmann et al., 2009; Xie et al., 2012; Zhou et al., 2017). We have recently identified a surprising and novel role for Hedgehog signaling in maintaining cardiac progenitor status and preventing premature differentiation (Rowton et al., 2018). In cardiac rhythm, we investigate the molecular mechanisms underlying the genetic basis of cardiac arrhythmias. We have defined the first molecular networks and linking GWAS loci in cardiac conduction (Arnolds et al, 2012), the first molecular network in Atrial Fibrillation, the most common arrhythmia world-wide (Nadadur et al., 2016) and the functional genomic mechanisms underlying genetic associations (Van den Boogaard et al., 2014).

One or more keywords matched the following items that are connected to Moskowitz, Ivan

Item TypeName
Concept Transcription Factors
Concept Basic-Leucine Zipper Transcription Factors
Concept Gene Regulatory Networks
Concept E2F3 Transcription Factor
Concept GATA4 Transcription Factor
Concept GATA6 Transcription Factor
Concept Kruppel-Like Transcription Factors
Concept Forkhead Transcription Factors
Academic Article Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice.
Academic Article The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system.
Academic Article A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.
Academic Article Characterization of sinoatrial node in four conduction system marker mice.
Academic Article Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.
Academic Article E2F3 plays an essential role in cardiac development and function.
Academic Article Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected]
Academic Article Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.
Academic Article Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects.
Academic Article Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.
Academic Article Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.
Academic Article Many ways to break a heart.
Academic Article Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.
Academic Article TBX5: A Key Regulator of Heart Development.
Academic Article Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation.
Academic Article Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm.
Academic Article A promoter interaction map for cardiovascular disease genetics.
Academic Article Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics.
Academic Article Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development.
Academic Article Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis.
Academic Article Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types.
Academic Article Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation.

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