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Search Results to Ivan Moskowitz

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One or more keywords matched the following properties of Moskowitz, Ivan

PropertyValue
keywords Cardiac Rhythm
keywords Cardiac Arrhythmias
overview The Moskowitz laboratory is devoted to the genetic, genomic and molecular study of gene regulatory networks. A single overarching theme governs work in the Moskowitz laboratory: that understanding essential gene regulatory networks will unveil the molecular logic governing biological processes, and that understanding network disruption will inform the molecular basis underlying disease. We have recently pioneered approaches to identify non-coding RNAs as markers and modulators of enhancer function (Yang and Nadadur et al, 2017). The Moskowitz laboratory has focused on two areas of cardiac biology: (1) cardiac conduction with respect to cardiac arrhythmias and (2) cardiac development with respect to Congenital Heart Disease (CHD). In cardiac development, we investigate the genetic, genomic and developmental landscape of cardiac morphogenesis. We have identified an essential role for Hedgehog signaling in the cardiac development and congenital heart disease and contributed to a paradigm shift in the understanding of cardiac septation (e.g. Hoffmann et al., 2009; Xie et al., 2012; Zhou et al., 2017). We have recently identified a surprising and novel role for Hedgehog signaling in maintaining cardiac progenitor status and preventing premature differentiation (Rowton et al., 2018). In cardiac rhythm, we investigate the molecular mechanisms underlying the genetic basis of cardiac arrhythmias. We have defined the first molecular networks and linking GWAS loci in cardiac conduction (Arnolds et al, 2012), the first molecular network in Atrial Fibrillation, the most common arrhythmia world-wide (Nadadur et al., 2016) and the functional genomic mechanisms underlying genetic associations (Van den Boogaard et al., 2014).

One or more keywords matched the following items that are connected to Moskowitz, Ivan

Item TypeName
Concept Arrhythmias, Cardiac
Concept Myocytes, Cardiac
Concept Death, Sudden, Cardiac
Concept Cardiac Myosins
Concept Electrophysiologic Techniques, Cardiac
Academic Article Ventricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene.
Academic Article Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice.
Academic Article The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system.
Academic Article Electrophysiologic characterization and postnatal development of ventricular pre-excitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White syndrome.
Academic Article A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.
Academic Article Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia.
Academic Article The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.
Academic Article Sarcomere mutations in cardiomyopathy with left ventricular hypertrabeculation.
Academic Article TBX5 drives Scn5a expression to regulate cardiac conduction system function.
Academic Article E2F3 plays an essential role in cardiac development and function.
Academic Article Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected]
Academic Article Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy.
Academic Article Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy.
Academic Article Inducible recombination in the cardiac conduction system of minK: CreERT² BAC transgenic mice.
Academic Article The emerging genetic landscape underlying cardiac conduction system function.
Academic Article Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.
Academic Article Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis.
Academic Article Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects.
Academic Article Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.
Academic Article Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.
Academic Article A common genetic variant within SCN10A modulates cardiac SCN5A expression.
Academic Article The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.
Academic Article Correction: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation.
Academic Article Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation.
Academic Article Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm.
Academic Article A promoter interaction map for cardiovascular disease genetics.
Academic Article A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human.
Academic Article A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice.
Academic Article Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development.
Academic Article Transcriptional Patterning of the Ventricular Cardiac Conduction System.
Academic Article ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction.
Academic Article Chamber-specific transcriptional responses in atrial fibrillation.

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