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One or more keywords matched the following properties of Liao, James
overview Dr. Liao is the Harold H. Hines Jr. Professor of Medicine and Chief of Cardiology Section at the University of Chicago. He is also the Director of the Physician Scientist Development Program and Principal Investigator of the NIH T32 Cardiovascular Sciences Training Grant. His laboratory has made many important discoveries, which has helped elucidate signaling mechanisms in the vascular wall. Specifically, his laboratory explored molecular pathways which revealed how HMG-CoA reductase inhibitors (or statins) could exert cholesterol-independent or "pleiotropic" effects. This translational work provided a mechanistic basis for the benefit of statin therapy in stroke patients for which he received and was awarded the Cardiovascular Research Prize from the American Heart Association. His laboratory also identified, cloned, and characterized a novel cytochrome P450 epoxygenase, CYP2J2, and its products, epoxyeicosatrienoic acids (EETs), as endothelium-derived hyporpolarizing factors with anti-inflammatory and anti-ischemic properties. In addition, his work also led to the discovery of a novel, rapid, nongenomic effect of steroid hormone receptors. For his research accomplishments, Dr. Liao received the Jeffrey M. Hoeg Arteriosclerosis, Thrombosis, and Vascular Biology Award from the American Heart Association and the Outstanding Investigator Award from the American Federation for Medical Research. He has served on numerous NIH study sections, advisory committees, and special emphasis panels.
One or more keywords matched the following items that are connected to Liao, James
Item TypeName
Concept Ischemic Attack, Transient
Concept Stroke Volume
Concept Stroke
Academic Article Secondary prevention of stroke and transient ischemic attack: is more platelet inhibition the answer?
Academic Article Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy.
Academic Article Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.
Academic Article Increased Rho kinase activity in congestive heart failure.
Academic Article Rapid effects of statins: from prophylaxis to therapy for ischemic stroke.
Academic Article Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors.
Academic Article Translational therapeutics of dipyridamole.
Academic Article Statins and ischemic stroke.
Academic Article Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR.
Academic Article Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids.
Academic Article NF-?B and innate immunity in ischemic stroke.
Academic Article Acute myocardial infarction after ergonovine administration for uterine bleeding.
Academic Article ROCKs as immunomodulators of stroke.
Academic Article Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice.
Academic Article Potential serum biomarkers in the pathophysiological processes of stroke.
Academic Article Linking Notch signaling to ischemic stroke.
Academic Article Additive effects of statin and dipyridamole on cerebral blood flow and stroke protection.
Academic Article Novel aspects of the roles of Rac1 GTPase in the cardiovascular system.
Academic Article Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase.
Academic Article Targeting eNOS and beyond: emerging heterogeneity of the role of endothelial Rho proteins in stroke protection.
Academic Article Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia.
Academic Article Rho-associated kinase activity is an independent predictor of cardiovascular events in acute coronary syndrome.
Academic Article Gene variations of ROCKs and risk of ischaemic stroke: the Women's Genome Health Study.
Academic Article Increased leukocyte ROCK activity in patients after acute ischemic stroke.
Academic Article Drug Insight: statins and stroke.
Academic Article Elevated homocysteine and C-reactive protein levels independently predict worsening prognosis after stroke in Chinese patients.
Academic Article Relative Lack of Culprit and Obstructive Coronary Lesions in Patients With Acute Ischemic Stroke and Elevated Cardiac Troponin.
Academic Article Role of statin pleiotropism in acute coronary syndromes and stroke.
Academic Article Genetically elevated C-reactive protein and ischemic vascular disease.
Academic Article Fingolimod provides long-term protection in rodent models of cerebral ischemia.
Academic Article RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations.
Academic Article Targeting eNOS for stroke protection.
Academic Article Direct vascular effects of HMG-CoA reductase inhibitors.
Academic Article Simvastatin reverses cardiac hypertrophy caused by disruption of the bradykinin 2 receptor.
Academic Article Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets.
Academic Article Beyond lipid lowering: the role of statins in vascular protection.
Academic Article Impaired Cognitive Performance in Endothelial Nitric Oxide Synthase Knockout Mice After Ischemic Stroke: A Pilot Study.
Academic Article ROCK as a therapeutic target for ischemic stroke.
Academic Article The Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia.
Academic Article Is statin discontinuation an option in patients who have had a stroke?
Academic Article Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
Academic Article A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.
Grant Novel Signaling Pathways in Ischemic Stroke
Grant Activation of eNOS by Steroid Hormones
Grant Role of PI3-Kinase in Estrogen-induced eNOS Activation
Search Criteria
  • Ischemic
  • Stroke