| Item Type | Name |
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Concept
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Mice, Inbred C3H
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Concept
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Mice, Inbred Strains
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Concept
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Mice, Transgenic
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Concept
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Mice, Inbred BALB C
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Concept
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Mice, Inbred C57BL
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Concept
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Mice, Inbred ICR
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Concept
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Mice, Knockout
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Concept
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Mice
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Concept
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Mice, Mutant Strains
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Academic Article
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Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.
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Academic Article
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Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells.
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Academic Article
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Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2.
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Academic Article
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Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.
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Academic Article
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A method for measuring Rho kinase activity in tissues and cells.
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Academic Article
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Essential role of endothelial Notch1 in angiogenesis.
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Academic Article
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Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.
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Academic Article
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Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice.
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Academic Article
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Smooth muscle Notch1 mediates neointimal formation after vascular injury.
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Academic Article
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Notch1 in bone marrow-derived cells mediates cardiac repair after myocardial infarction.
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Academic Article
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ROCK inhibition prevents fetal serum-induced alteration in structure and function of organ-cultured mesenteric artery.
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Academic Article
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Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion.
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Academic Article
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Role of Rho kinase isoforms in murine allergic airway responses.
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Academic Article
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Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis.
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Academic Article
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Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice.
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Academic Article
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Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen.
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Academic Article
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Notch signaling regulates endothelial progenitor cell activity during recovery from arterial injury in hypercholesterolemic mice.
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Academic Article
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Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt.
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Academic Article
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Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells.
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Academic Article
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Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors.
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Academic Article
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Activated Rho kinase mediates diabetes-induced elevation of vascular arginase activation and contributes to impaired corpora cavernosa relaxation: possible involvement of p38 MAPK activation.
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Academic Article
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Pitavastatin-induced angiogenesis and arteriogenesis is mediated by Notch1 in a murine hindlimb ischemia model without induction of VEGF.
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Academic Article
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A mouse model of diet-induced obesity and insulin resistance.
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Academic Article
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gamma-Secretase inhibitor reduces diet-induced atherosclerosis in apolipoprotein E-deficient mice.
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Academic Article
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ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression.
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Academic Article
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FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1.
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Academic Article
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Translational therapeutics of dipyridamole.
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Academic Article
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Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation.
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Academic Article
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Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription.
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Academic Article
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Rac1 is a critical mediator of endothelium-derived neurotrophic activity.
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Academic Article
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Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase.
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Academic Article
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Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.
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Academic Article
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VEGF increases retinal vascular ICAM-1 expression in vivo.
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Academic Article
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Abrogation of airway hyperresponsiveness but not inflammation by rho kinase insufficiency.
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Academic Article
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Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR.
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Academic Article
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Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms.
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Academic Article
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Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids.
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Academic Article
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Critical role of exogenous nitric oxide in ROCK activity in vascular smooth muscle cells.
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Academic Article
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Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.
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Academic Article
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Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2.
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Academic Article
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Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment.
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Academic Article
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Neuroprotection mediated by changes in the endothelial actin cytoskeleton.
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Academic Article
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Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury.
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Academic Article
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Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.
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Academic Article
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Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice.
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Academic Article
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Regulation of myogenic terminal differentiation by the hairy-related transcription factor CHF2.
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Academic Article
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Requirement of Rac1 in the development of cardiac hypertrophy.
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Academic Article
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ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.
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Academic Article
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Linking Notch signaling to ischemic stroke.
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Academic Article
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Additive effects of statin and dipyridamole on cerebral blood flow and stroke protection.
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Academic Article
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Statin therapy: having the good without the bad.
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Academic Article
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Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway.
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Academic Article
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Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants.
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Academic Article
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RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis.
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Academic Article
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Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1.
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Academic Article
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FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2.
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Academic Article
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Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation.
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Academic Article
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Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase.
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Academic Article
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Rapid nongenomic actions of thyroid hormone.
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Academic Article
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Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy.
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Academic Article
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Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia.
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Academic Article
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Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase.
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Academic Article
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MnTBAP stimulates angiogenic functions in endothelial cells through mitofusin-1.
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Academic Article
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ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice.
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Academic Article
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Critical role of endothelial Notch1 signaling in postnatal angiogenesis.
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Academic Article
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Distribution of sphingosine kinase activity and mRNA in rodent brain.
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Academic Article
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Rho Kinases and Cardiac Remodeling.
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Academic Article
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MnTBAP increases BMPR-II expression in endothelial cells and attenuates vascular inflammation.
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Academic Article
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Fingolimod provides long-term protection in rodent models of cerebral ischemia.
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Academic Article
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RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations.
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Academic Article
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Role of ROCK2 in CD4+ cells in allergic airways responses in mice.
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Academic Article
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Simvastatin reverses cardiac hypertrophy caused by disruption of the bradykinin 2 receptor.
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Academic Article
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Notch signaling as an important mediator of cardiac repair and regeneration after myocardial infarction.
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Academic Article
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Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets.
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Academic Article
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Vascular protection by estrogen in ischemia-reperfusion injury requires endothelial nitric oxide synthase.
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Academic Article
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Impaired Cognitive Performance in Endothelial Nitric Oxide Synthase Knockout Mice After Ischemic Stroke: A Pilot Study.
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Academic Article
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Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice.
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Academic Article
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Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4.
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Academic Article
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The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis.
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Academic Article
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Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
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Academic Article
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A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.
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Academic Article
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Targeting Rho-associated coiled-coil forming protein kinase (ROCK) in cardiovascular fibrosis and stiffening.
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Academic Article
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Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis.
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Academic Article
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Regulator of G-Protein Signaling 5 Maintains Brain Endothelial Cell Function in Focal Cerebral Ischemia.
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Academic Article
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Increase in Blood-Brain Barrier (BBB) Permeability Is Regulated by MMP3 via the ERK Signaling Pathway.
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Academic Article
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Vascular Stiffening Mediated by Rho-Associated Coiled-Coil Containing Kinase Isoforms.
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Grant
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Cellular Determinants of Adipocyte Phenotype and Function
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Grant
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Novel Signaling Pathways in Ischemic Stroke
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Grant
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Endothelial Akt in Vascular Injury
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Grant
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ROCK and Obesity
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Grant
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Lipoproteins Effect on G Protein Function
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Grant
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Activation of eNOS by Steroid Hormones
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Grant
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Mechanisms Underlying Vascular Aging
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Grant
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Role of PI3-Kinase in Estrogen-induced eNOS Activation
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