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Search Results to David R. Kovar

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overview Cells simultaneously assemble and maintain different actin cytoskeleton networks of distinct organizations and dynamics for fundamental processes such as polarization, endocytosis, motility and division. How does a shared pool of actin monomer building blocks self-organize into distinct actin filament networks of specific densities, sizes and function within a common cellular cytoplasm? Our research group is investigating the molecular mechanisms that govern how diverse actin cytoskeleton networks self-organize through (1) competition for a limited supply of actin monomers, (2) network-specific sorting of actin binding proteins, and (3) the effects of different combinations of actin binding proteins on actin filament network organization, dynamics and function. We take advantage of complementary experiments in live cells and with purified components. These interdisciplinary techniques include genetics, time-lapse fluorescence microscopy of cells, biochemistry, biophysics, in vitro reconstitution and multi-color single molecule TIRF microscopy imaging.

One or more keywords matched the following items that are connected to Kovar, David R.

Item TypeName
Concept Bacterial Proteins
Concept Chromosomal Proteins, Non-Histone
Concept Contractile Proteins
Concept DNA-Binding Proteins
Concept Microtubule-Associated Proteins
Concept Membrane Proteins
Concept Microfilament Proteins
Concept Plant Proteins
Concept Protein Binding
Concept Protein Conformation
Concept Protein Kinases
Concept Protein Structure, Quaternary
Concept Protein Subunits
Concept Protozoan Proteins
Concept Protein Structure, Tertiary
Concept RNA-Binding Proteins
Concept Protein Transport
Concept Drosophila Proteins
Concept Protein Structure, Secondary
Concept Green Fluorescent Proteins
Concept Actin-Related Protein 2
Concept Cell Cycle Proteins
Concept Schizosaccharomyces pombe Proteins
Concept Arabidopsis Proteins
Concept Saccharomyces cerevisiae Proteins
Concept Actin Capping Proteins
Concept Recombinant Proteins
Concept Protein Interaction Domains and Motifs
Concept Protein Multimerization
Concept LIM Domain Proteins
Concept GTP-Binding Proteins
Concept Caenorhabditis elegans Proteins
Concept Molecular Motor Proteins
Concept Structural Homology, Protein
Concept CapZ Actin Capping Protein
Concept Protein Interaction Maps
Concept Actin-Related Protein 2-3 Complex
Concept Actin-Related Protein 3
Concept Protein Stability
Concept Carrier Proteins
Concept Cytoskeletal Proteins
Concept Fetal Proteins
Concept Luminescent Proteins
Concept Nuclear Proteins
Concept Recombinant Fusion Proteins
Concept Protein Isoforms
Academic Article Actin filament bundling by fimbrin is important for endocytosis, cytokinesis, and polarization in fission yeast.
Academic Article The characterization of ligand-specific maize (Zea mays) profilin mutants.
Academic Article Fluorescently-labeled fimbrin decorates a dynamic actin filament network in live plant cells.
Academic Article Actin and actin-binding proteins in higher plants.
Academic Article Characterization of Ricinus communis phloem profilin, RcPRO1.
Academic Article The fission yeast cytokinesis formin Cdc12p is a barbed end actin filament capping protein gated by profilin.
Academic Article Insertional assembly of actin filament barbed ends in association with formins produces piconewton forces.
Academic Article Pollen profilin function depends on interaction with proline-rich motifs.
Academic Article Control of the assembly of ATP- and ADP-actin by formins and profilin.
Academic Article Assembly of the cytokinetic contractile ring from a broad band of nodes in fission yeast.
Academic Article Maize profilin isoforms are functionally distinct.
Academic Article Technical advance: identification of plant actin-binding proteins by F-actin affinity chromatography.
Academic Article AtFim1 is an actin filament crosslinking protein from Arabidopsis thaliana.
Academic Article Progressing actin: Formin as a processive elongation machine.
Academic Article Twinfilin is an actin-filament-severing protein and promotes rapid turnover of actin structures in vivo.
Academic Article Cell polarity: formin on the move.
Academic Article Arabidopsis capping protein (AtCP) is a heterodimer that regulates assembly at the barbed ends of actin filaments.
Academic Article Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis.
Academic Article A plant-specific kinesin binds to actin microfilaments and interacts with cortical microtubules in cotton fibers.
Academic Article Formin differentially utilizes profilin isoforms to rapidly assemble actin filaments.
Academic Article Signal-mediated depolymerization of actin in pollen during the self-incompatibility response.
Academic Article Chlamydomonas reinhardtii produces a profilin with unusual biochemical properties.
Academic Article Role of tropomyosin in formin-mediated contractile ring assembly in fission yeast.
Academic Article Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1.
Academic Article Incompatibility with formin Cdc12p prevents human profilin from substituting for fission yeast profilin: insights from crystal structures of fission yeast profilin.
Academic Article Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem W domain nucleation.
Academic Article Structure of the actin crosslinking core of fimbrin.
Academic Article Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast.
Academic Article Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly.
Academic Article Actin assembly factors regulate the gelation kinetics and architecture of F-actin networks.
Academic Article The functionally distinct fission yeast formins have specific actin-assembly properties.
Academic Article Molecular details of formin-mediated actin assembly.
Academic Article Model of formin-associated actin filament elongation.
Academic Article The cytokinesis formins from the nematode worm and fission yeast differentially mediate actin filament assembly.
Academic Article Fimbrin and tropomyosin competition regulates endocytosis and cytokinesis kinetics in fission yeast.
Academic Article Rickettsia Sca2 is a bacterial formin-like mediator of actin-based motility.
Academic Article Three's company: the fission yeast actin cytoskeleton.
Academic Article Rickettsia Sca2 has evolved formin-like activity through a different molecular mechanism.
Academic Article Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.
Academic Article Fission yeast profilin is tailored to facilitate actin assembly by the cytokinesis formin Cdc12.
Academic Article Attachment conditions control actin filament buckling and the production of forces.
Academic Article SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis.
Academic Article Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex.
Academic Article In vitro reconstitution of an mRNA-transport complex reveals mechanisms of assembly and motor activation.
Academic Article Homeostatic actin cytoskeleton networks are regulated by assembly factor competition for monomers.
Academic Article A mechanism for actin filament severing by malaria parasite actin depolymerizing factor 1 via a low affinity binding interface.
Academic Article Enabled negatively regulates diaphanous-driven actin dynamics in vitro and in vivo.
Academic Article Ena/VASP Enabled is a highly processive actin polymerase tailored to self-assemble parallel-bundled F-actin networks with Fascin.
Academic Article HopW1 from Pseudomonas syringae disrupts the actin cytoskeleton to promote virulence in Arabidopsis.
Academic Article Arp2/3 ATP hydrolysis: to branch or to debranch?
Academic Article The formins Cdc12 and For3 cooperate during contractile ring assembly in cytokinesis.
Academic Article High-resolution temporal analysis reveals a functional timeline for the molecular regulation of cytokinesis.
Academic Article Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites.
Academic Article ACTIN-DIRECTED TOXIN. ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.
Academic Article In Vitro Biochemical Characterization of Cytokinesis Actin-Binding Proteins.
Academic Article The F-actin bundler a-actinin Ain1 is tailored for ring assembly and constriction during cytokinesis in fission yeast.
Academic Article Internetwork competition for monomers governs actin cytoskeleton organization.
Academic Article Fascin- and a-Actinin-Bundled Networks Contain Intrinsic Structural Features that Drive Protein Sorting.
Academic Article Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks.
Academic Article The bacterial virulence factors VopL and VopF nucleate actin from the pointed end.
Academic Article Partitioning and Enhanced Self-Assembly of Actin in Polypeptide Coacervates.
Academic Article Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly.
Academic Article Actin Cross-Linking Toxin Is a Universal Inhibitor of Tandem-Organized and Oligomeric G-Actin Binding Proteins.
Academic Article Ena/VASP processive elongation is modulated by avidity on actin filaments bundled by the filopodia cross-linker fascin.
Academic Article Feeling the force: formin's role in mechanotransduction.
Academic Article Cooperation between tropomyosin and a-actinin inhibits fimbrin association with actin filament networks in fission yeast.
Academic Article Mechanical and kinetic factors drive sorting of F-actin cross-linkers on bundles.
Academic Article Pseudomonas aeruginosa exoenzyme Y directly bundles actin filaments.
Academic Article Evolutionarily diverse LIM domain-containing proteins bind stressed actin filaments through a conserved mechanism.

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