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Search Results to Elizabeth Grove

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One or more keywords matched the following properties of Grove, Elizabeth

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keywords Developmental Disabilities
keywords Developmental Biology
keywords Developmental Gene Expression Regulation
overview Determining the mechanisms of cerebral cortical development is essential to understanding the functions, disorders, and evolution of the brain. My research focuses on the embryonic and early postnatal development of cerebral cortex in the mouse. Specific questions include: how part of the embryonic neuroepithelium is divided, or “patterned” into the neocortex and hippocampus; how different hippocampal neuronal cell types are specified; and how a consistent map of functionally distinct areas is laid out in neocortex. To a developmental biologist the cerebral cortex may seem too complex a system for studies of tissue patterning and cell type specification. My lab, however, has contributed to a model in which the embryonic cortex is initially patterned by secreted signaling molecules, including Fibroblast Growth Factor (FGF) 8, and the Wnt protein, Wnt3a, together with downstream transcription factors, in much the same way as in the rest of the embryo. FGF8 disperses from an anterior source to establish the anterior to posterior (A/P) axis of the neocortical area map. Wnt3a influences the medial to lateral (M/L) axis and is also required for development of the hippocampus. Together, FGF8 and Wnt3a shape expression gradients of transcription factor genes that control the size and position of neocortical areas as well as hippocampal growth. This model is still incomplete. For example, how sharp area boundaries arise from graded gene expression is unclear. Classically, for this step, a mechanism specific to the nervous system is proposed, namely the growth of axons from the thalamus into the neocortex. Yet previous findings indicate that precise guidance cues lie within nascent neocortical areas. To identify area-specific axon guidance molecules, we plan to harvest in cells from a mouse in which sensory areas are marked by green fluorescence, and compare the transcriptomes of different areas using RNA-Seq. A major outstanding task is to determine if our model of cortical patterning, based on studies of the mouse, holds for larger, multi-folded (gyrencephalic) brains of carnivores and primates. Common features of the area map, conserved across mammals, suggest the model could generalize, and early evidence from a study of the gyrencephalic ferret supports this hypothesis. Methods: Candidate genes are identified and their function altered using mouse genetics and a fine-scale method of in utero microelectroporation that we pioneered. The cortical phenotype of mice in which gene function is altered is analyzed by area-specific gene and protein expression and connectivity, and occasionally by behavior. We discovered, for instance, that part of the hippocampus is shrunken in mice deficient in BMP signaling, and that these mice were "fearless" in situations that would normally induce anxiety, supporting a new view of hippocampal function. Cell type specific transcriptomes will be identified with single cell RNA-Seq.

One or more keywords matched the following items that are connected to Grove, Elizabeth

Item TypeName
Concept Embryonic and Fetal Development
Concept Gene Expression Regulation, Developmental
Concept Embryonic Development
Academic Article The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice.
Academic Article Early specification and autonomous development of cortical fields in the mouse hippocampus.
Academic Article A local Wnt-3a signal is required for development of the mammalian hippocampus.
Academic Article Patterning events and specification signals in the developing hippocampus.
Academic Article Emx2 is required for growth of the hippocampus but not for hippocampal field specification.
Academic Article The telencephalon saved by TLC.
Academic Article LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem.
Academic Article Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor.
Academic Article The chemokine stromal cell-derived factor-1 regulates the migration of sensory neuron progenitors.
Academic Article Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia.
Academic Article Wnt genes define distinct boundaries in the developing human brain: implications for human forebrain patterning.
Academic Article Massive loss of Cajal-Retzius cells does not disrupt neocortical layer order.
Academic Article Patterning the dorsal telencephalon: a role for sonic hedgehog?
Academic Article Turning neurons into a nervous system.
Academic Article Presenilin 1 in migration and morphogenesis in the central nervous system.
Academic Article The derivatives of the Wnt3a lineage in the central nervous system.
Academic Article Embryonic signaling centers expressing BMP, WNT and FGF proteins interact to pattern the cerebral cortex.
Academic Article FGF8 acts as a classic diffusible morphogen to pattern the neocortex.
Academic Article Wnt signaling meets internal dissent.
Academic Article Shh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrain.
Academic Article The generation of cellular diversity in the cerebral cortex.
Academic Article Bone morphogenetic protein signaling in the developing telencephalon controls formation of the hippocampal dentate gyrus and modifies fear-related behavior.
Academic Article Generating the cerebral cortical area map.
Academic Article Members of the Wnt, Fz, and Frp gene families expressed in postnatal mouse cerebral cortex.
Academic Article Multiple restricted lineages in the embryonic rat cerebral cortex.
Academic Article Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections.
Academic Article The cortical hem regulates the size and patterning of neocortex.
Academic Article DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation.
Academic Article Lateral Thalamic Eminence: A Novel Origin for mGluR1/Lot Cells.
Award or Honor Receipt Krieg Cortical Kudos Discoverer Award, Contribution to Understanding Cortical Development
Academic Article DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors.
Grant Genetic Induction of the Olfactory Bulb and Regulation of Olfactory Axon Guidepost Cells
Grant Molecular Mechanisms of Cerebral Cortical Patterning
Grant Role Of The Cortical Hem In Patterning The Telencephalon
Grant Molecular Mechanisms of Cerebral Cortical Patterning
Grant Specifying the Neocortical Area Map in the Ferret
Grant Cortical control over area-specific thalamic input
Academic Article A model of neocortical area patterning in the lissencephalic mouse may hold for larger gyrencephalic brains.

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