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One or more keywords matched the following properties of Alegre, Maria-Luisa
keywords Transplant Rejection
overview My laboratory is interested in T cell responses in settings of transplantation, autoimmunity and cancer, with an emphasis on mouse models and emerging extensions onto clinical translation. A main focus of the laboratory is on T cell tolerance in transplantation and how infections and inflammatory events can affect induction or maintenance of tolerance. We have found that transplantation tolerance can exist at different levels of robustness based on the number of mechanisms of T cell tolerance that are engaged, and that infections or inflammation can erode such tolerance. The impact of bacterial infections on transplant outcomes has led us to discover that the microbiota also influences immune responses to transplanted organs and can be manipulated to prolong graft survival. Our clinical studies have focused on the immunology of transplant recipients and of patients infected with the bacteria that influence transplant outcomes and, collaboratively, we have explored the involvement of the microbiota in the responsiveness of melanoma patients to immunotherapy.
One or more keywords matched the following items that are connected to Alegre, Maria-Luisa
Item TypeName
Concept Graft vs Host Disease
Concept Graft Survival
Concept Graft Rejection
Concept Graft Enhancement, Immunologic
Concept Heart
Concept Graft vs Host Reaction
Concept Transplants
Concept Lung Transplantation
Concept Heart Transplantation
Academic Article Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.
Academic Article Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.
Academic Article Costimulatory molecules as targets for the induction of transplantation tolerance.
Academic Article Transplantation and the CD28/CTLA4/B7 pathway.
Academic Article Role of STAT6 signaling in the induction and long-term maintenance of tolerance mediated by CTLA4-Ig.
Academic Article Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice.
Academic Article Secondary lymphoid organs are important but not absolutely required for allograft responses.
Academic Article Impaired NF-kappaB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin grafts.
Academic Article CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway.
Academic Article Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.
Academic Article Transplantation tolerance in NF-kappaB-impaired mice is not due to regulation but is prevented by transgenic expression of Bcl-xL.
Academic Article Role of natural killer cell subsets in cardiac allograft rejection.
Academic Article Costimulatory molecules as targets for the induction of transplantation tolerance.
Academic Article Cellular mechanisms underlying acute graft rejection: time for reassessment.
Academic Article Overexpression of program death-1 in T cells has mild impact on allograft survival.
Academic Article Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection.
Academic Article Toll-like receptor signaling in transplantation.
Academic Article Fas mediates cardiac allograft acceptance in mice with impaired T-cell-intrinsic NF-kappaB signaling.
Academic Article The multiple facets of toll-like receptors in transplantation biology.
Academic Article Toll-like receptors (TLRs) in transplantation.
Academic Article TLR signals promote IL-6/IL-17-dependent transplant rejection.
Academic Article Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome.
Academic Article Bacterial infections, alloimmunity, and transplantation tolerance.
Academic Article IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice.
Academic Article The inside story of dendritic cell immunotherapy.
Academic Article Commensal microbiota determine intestinal iTreg.
Academic Article Role of T cell-nuclear factor ?B in transplantation.
Academic Article The impact of infection and tissue damage in solid-organ transplantation.
Academic Article "Tip-toeing" to an assay for transplantation tolerance?
Academic Article Literature watch implications for transplantation. The anti-infectious role of the IL-17 pathway.
Academic Article TLR engagement prevents transplantation tolerance.
Academic Article Attenuation by targeting the B- and T-cell attenuator.
Academic Article An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity.
Academic Article Immunomodulation of transplant rejection using monoclonal antibodies and soluble receptors.
Academic Article Epidermal Langerhans cells promote skin allograft rejection in mice with NF-kappa B-impaired T cells.
Academic Article Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes.
Academic Article A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo.
Academic Article Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts.
Academic Article Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model.
Academic Article Role of T-cell-specific nuclear factor ?B in islet allograft rejection.
Academic Article CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo.
Academic Article Antagonistic effect of toll-like receptor signaling and bacterial infections on transplantation tolerance.
Academic Article The microbiota, the immune system and the allograft.
Academic Article IFN-?: The Dr. Jekyll and Mr. Hyde of immunology?
Academic Article Transplantation tolerance and its outcome during infections and inflammation.
Academic Article Lessons and limits of mouse models.
Academic Article Microbes and allogeneic transplantation.
Academic Article The influence of the microbiota on the immune response to transplantation.
Academic Article Spontaneous restoration of transplantation tolerance after acute rejection.
Academic Article High-Fat Diet-Induced Obesity Enhances Allograft Rejection.
Academic Article The composition of the microbiota modulates allograft rejection.
Academic Article Delayed Cytotoxic T Lymphocyte-Associated Protein 4-Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute Rejection.
Academic Article Standardizing Mouse Models to Account for Host-Microbial Interactions.
Academic Article Antigen Presentation in Transplantation.
Academic Article Adoptive Transfer of Tracer-Alloreactive CD4+ T Cell Receptor Transgenic T Cells Alters the Endogenous Immune Response to an Allograft.
Academic Article Natural killer cell subsets in allograft rejection and tolerance.
Academic Article Long-term Maintenance of Sterility Following Skin Transplantation in Germ-free Mice.
Academic Article Transplantation tolerance after allograft rejection.
Academic Article Super-MANF to the Rescue: Immunomodulation Improves Retinal Repair and Regenerative Cell Therapy.
Academic Article Erosion of Transplantation Tolerance After Infection.
Academic Article Tracking of TCR-Transgenic T Cells Reveals That Multiple Mechanisms Maintain Cardiac Transplant Tolerance in Mice.
Academic Article The Multiple Molecular Paths of Antibody Suppression by TFR Cells.
Academic Article Dendritic Cell Identification for Dummies.
Academic Article Ionic Checkpoint: Potassium-Driven T Cell Immunosuppression.
Academic Article The Tpm Subset of the CD8+ T Cell Memory Family.
Academic Article Impact of environmental factors on alloimmunity and transplant fate.
Academic Article Select Effects of IL-13 in Driving Tissue Repair and Fibrosis.
Academic Article Evolving Approaches in the Identification of Allograft-Reactive T and B Cells in Mice and Humans.
Academic Article The Bugs That Keep Us Safe.
Academic Article Creating a Niche.
Academic Article Danger, Metabolism and T Cell Memory.
Academic Article Sweet T Cell Dysfunction.
Academic Article Preventing PTLD?
Academic Article What's new in transplantation tolerance?
Academic Article Gut microbes contribute to variation in solid organ transplant outcomes in mice.
Academic Article Novel Role of Calcineurin Inhibitors in Curbing T Cells' Sweet Tooth.
Academic Article The Unbearable Lightness of Breathing.
Academic Article Timing Is Everything.
Academic Article Equal Expansion of Endogenous Transplant-Specific Regulatory T Cell and Recruitment Into the Allograft During Rejection and Tolerance.
Academic Article The outstanding questions in transplantation: It's about timeā€¦.
Academic Article Anti-Inflammatory Effects of Nonprofessional Phagocyte.
Academic Article DC Metabolism Controls Lung T Cell Polarization.
Academic Article Th17 Cells Changing Colors.
Academic Article Immune-Electrical Connection.
Academic Article Making Therapeutic Antibodies in Vitro.
Academic Article Predicting TCR specificity?
Academic Article A Cause for Leaky Guts.
Academic Article Metabolic Control of T Cell Memory.
Academic Article Distinct Graft-Specific TCR Avidity Profiles during Acute Rejection and Tolerance.
Academic Article Stealing Tregs' Identity (by Deleting NF-?B).
Academic Article Immune Regulation of Lung Fibrosis.
Academic Article Mind the GAP, for Tolerance to Gut Bacteria.
Academic Article The Adaptive NK Cell Response.
Academic Article The Importance of Inflammation-induced NETS.
Academic Article Gut Microbiota Can Impact Chronic Murine Lung Allograft Rejection.
Academic Article B cells, CMV, and stem cell transplant.
Academic Article Exercise increases skin graft resistance to rejection.
Academic Article A molecular pathway for indirect presentation?
Academic Article The pursuit of transplantation tolerance: new mechanistic insights.
Academic Article A New Ligand for LAG-3.
Academic Article Outstanding questions in transplantation: An introduction to this minireview series.
Academic Article Treg Respiration.
Academic Article Harnessing the commensal microbiota to improve immune responses.
Academic Article Fifty Shades of Tolerance: Beyond a Binary Tolerant/Non-Tolerant Paradigm.
Academic Article Neuroimmunology and the control of T cell migration.
Grant Impact of Microbiota on Alloimmune Responses in Transplantation
Grant Infections and the Stability of Transplantation Tolerance
Grant The microbiota and allograft rejection: novel investigations into the consequences of obesity
Academic Article Lymph node segregation for tolerance or inflammation.
Academic Article Skin-restricted commensal colonization accelerates skin graft rejection.
Academic Article Teamwork by IL-10+ and IL-35+ Tregs.
Academic Article Fibroblasts can have subsets too!
Academic Article Innate lymphoid cells coming of age.
Academic Article Impact of the microbiota on solid organ transplant rejection.
Academic Article Resilience of T cell-intrinsic dysfunction in transplantation tolerance.
Academic Article DeTOXifying exhausted T cells.
Academic Article Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients.
Academic Article Pathogenic Bhlhe40+ GM-CSF+ CD4+ T cells promote indirect alloantigen presentation in the GI tract during GVHD.
Academic Article The initiation of graft-versus-host disease.
Academic Article The First International Transplant Science (ITS) Meeting.
Academic Article In vivo and in vitro differences in CD8+ T cell metabolism.
Academic Article Giving effector/memory T cells a new (suppressive) purpose.
Academic Article Exploiting immunometabolism and T cell function for solid organ transplantation.
Academic Article Immune impact of commensals versus pathobionts.
Academic Article Liver Protection by ILC1s.
Academic Article The First ITS Meeting.
Academic Article The anti-inflammatory function of the apoptotic secretome.
Academic Article Metabolomic profiling reveals clinically relevant microbiota-linked metabolites.
Academic Article The COVID-19 pandemic: A community approach.
Academic Article Influence of the microbiome on solid organ transplant survival.
Academic Article Taurodeoxycholic acid and valine reverse obesity-associated augmented alloimmune responses and prolong allograft survival.
Academic Article Toward an understanding of allogeneic conflict in pregnancy and transplantation.
Academic Article Oral alloantigen exposure promotes donor-specific tolerance in a mouse model of minor-mismatched skin transplantation.
Academic Article Linked sensitization by memory CD4+ T cells prevents costimulation blockade-induced transplantation tolerance.
Academic Article Host-versus-commensal immune responses participate in the rejection of colonized solid organ transplants.
Academic Article Reduced Satb1 expression predisposes CD4+ T conventional cells to Treg suppression and promotes transplant survival.
Academic Article Oral administration of the commensal Alistipes onderdonkii prolongs allograft survival.
Concept Transplant Recipients
Grant Role of NF-kB Activation in Acute Allograft Rejection
Grant Mechanisms of TLR-mediated prevention of transplantation tolerance
Grant Role of NF-kB Activation in Acute Allograft Rejection
Grant NF-kappaBeta activation T cell function/graft rejection
Academic Article Microbiota-dependent and -independent effects of obesity on transplant rejection and hyperglycemia.
Search Criteria
  • Heart
  • Lung
  • Transplant