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Search Results to Maria-Luisa Alegre

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overview My laboratory is interested in T cell responses in settings of transplantation, autoimmunity and cancer, with an emphasis on mouse models and emerging extensions onto clinical translation. A main focus of the laboratory is on T cell tolerance in transplantation and how infections and inflammatory events can affect induction or maintenance of tolerance. We have found that transplantation tolerance can exist at different levels of robustness based on the number of mechanisms of T cell tolerance that are engaged, and that infections or inflammation can erode such tolerance. The impact of bacterial infections on transplant outcomes has led us to discover that the microbiota also influences immune responses to transplanted organs and can be manipulated to prolong graft survival. Our clinical studies have focused on the immunology of transplant recipients and of patients infected with the bacteria that influence transplant outcomes and, collaboratively, we have explored the involvement of the microbiota in the responsiveness of melanoma patients to immunotherapy.

One or more keywords matched the following items that are connected to Alegre, Maria-Luisa

Item TypeName
Concept Bacterial Infections
Concept Cross Infection
Concept Cytomegalovirus Infections
Concept Respiratory Tract Infections
Concept Staphylococcal Skin Infections
Concept Staphylococcal Infections
Concept Soft Tissue Infections
Concept Salmonella Infections, Animal
Academic Article Toll-like receptor signaling in transplantation.
Academic Article Bacterial infections, alloimmunity, and transplantation tolerance.
Academic Article IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice.
Academic Article The impact of infection and tissue damage in solid-organ transplantation.
Academic Article Literature watch implications for transplantation. The anti-infectious role of the IL-17 pathway.
Academic Article Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes.
Academic Article Role of bacterial infections in allograft rejection.
Academic Article Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model.
Academic Article Antagonistic effect of toll-like receptor signaling and bacterial infections on transplantation tolerance.
Academic Article Protective immunity against recurrent Staphylococcus aureus skin infection requires antibody and interleukin-17A.
Academic Article Transplantation tolerance and its outcome during infections and inflammation.
Academic Article Microbes and allogeneic transplantation.
Academic Article Proteomic Identification of saeRS-Dependent Targets Critical for Protective Humoral Immunity against Staphylococcus aureus Skin Infection.
Academic Article Impact of Staphylococcus aureus USA300 Colonization and Skin Infections on Systemic Immune Responses in Humans.
Academic Article Erosion of Transplantation Tolerance After Infection.
Academic Article Gut Microbiota Can Impact Chronic Murine Lung Allograft Rejection.
Academic Article B cells, CMV, and stem cell transplant.
Academic Article Retrospective Identification of a Broad IgG Repertoire Differentiating Patients With S. aureus Skin and Soft Tissue Infections From Controls.
Academic Article Mouse microbiomes: overlooked culprits of experimental variability.
Grant Impact of Microbiota on Alloimmune Responses in Transplantation
Grant Infections and the Stability of Transplantation Tolerance
Academic Article Inhibition of protective immunity against Staphylococcus aureus infection by MHC-restricted immunodominance is overcome by vaccination.

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  • Infections