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One or more keywords matched the following properties of Alegre, Maria-Luisa
keywords Immunology
keywords Immunology, Transplantation
overview My laboratory is interested in T cell responses in settings of transplantation, autoimmunity and cancer, with an emphasis on mouse models and emerging extensions onto clinical translation. A main focus of the laboratory is on T cell tolerance in transplantation and how infections and inflammatory events can affect induction or maintenance of tolerance. We have found that transplantation tolerance can exist at different levels of robustness based on the number of mechanisms of T cell tolerance that are engaged, and that infections or inflammation can erode such tolerance. The impact of bacterial infections on transplant outcomes has led us to discover that the microbiota also influences immune responses to transplanted organs and can be manipulated to prolong graft survival. Our clinical studies have focused on the immunology of transplant recipients and of patients infected with the bacteria that influence transplant outcomes and, collaboratively, we have explored the involvement of the microbiota in the responsiveness of melanoma patients to immunotherapy.
One or more keywords matched the following items that are connected to Alegre, Maria-Luisa
Item TypeName
Concept Alleles
Concept Amino Acid Sequence
Concept Base Sequence
Concept Genes, Immunoglobulin
Concept Genes, MHC Class I
Concept Molecular Sequence Data
Concept Major Histocompatibility Complex
Concept Sequence Homology, Nucleic Acid
Concept Transplantation Immunology
Concept Sequence Homology, Amino Acid
Concept Genes, Reporter
Concept Transgenes
Concept src Homology Domains
Concept Cloning, Molecular
Concept Genetic Loci
Academic Article Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression.
Academic Article Humanized OKT3 antibodies: successful transfer of immune modulating properties and idiotype expression.
Academic Article Tissue distribution, regulation and intracellular localization of murine CD1 molecules.
Academic Article Impaired negative selection in CD28-deficient mice.
Academic Article Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody.
Academic Article Costimulatory molecules as targets for the induction of transplantation tolerance.
Academic Article Secondary lymphoid organs are important but not absolutely required for allograft responses.
Academic Article Transplantation tolerance in NF-kappaB-impaired mice is not due to regulation but is prevented by transgenic expression of Bcl-xL.
Academic Article The multiple facets of toll-like receptors in transplantation biology.
Academic Article Toll-like receptors (TLRs) in transplantation.
Academic Article Bacterial infections, alloimmunity, and transplantation tolerance.
Academic Article Role of T cell-nuclear factor ?B in transplantation.
Academic Article An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity.
Academic Article Sequence and functional characterization of feline interleukin 2.
Academic Article Antagonistic effect of toll-like receptor signaling and bacterial infections on transplantation tolerance.
Academic Article IFN-?: The Dr. Jekyll and Mr. Hyde of immunology?
Academic Article Lessons and limits of mouse models.
Academic Article Antigen Presentation in Transplantation.
Academic Article The Multiple Molecular Paths of Antibody Suppression by TFR Cells.
Academic Article A molecular pathway for indirect presentation?
Academic Article Resilience of T cell-intrinsic dysfunction in transplantation tolerance.
Academic Article Introduction to this Cellular Immunology issue on new advances in solid organ transplantation immunology.
Award or Honor Receipt Section Editor
Award or Honor Receipt Board of Directors
Award or Honor Receipt Chair
Grant Mechanisms of TLR-mediated prevention of transplantation tolerance
Grant Epidemic CA-MRSA: Molecular Epidemiology and Immunology
Search Criteria
  • Molecular
  • Immunology