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One or more keywords matched the following properties of Alegre, Maria-Luisa
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overview My laboratory is interested in T cell responses in settings of transplantation, autoimmunity and cancer, with an emphasis on mouse models and emerging extensions onto clinical translation. A main focus of the laboratory is on T cell tolerance in transplantation and how infections and inflammatory events can affect induction or maintenance of tolerance. We have found that transplantation tolerance can exist at different levels of robustness based on the number of mechanisms of T cell tolerance that are engaged, and that infections or inflammation can erode such tolerance. The impact of bacterial infections on transplant outcomes has led us to discover that the microbiota also influences immune responses to transplanted organs and can be manipulated to prolong graft survival. Our clinical studies have focused on the immunology of transplant recipients and of patients infected with the bacteria that influence transplant outcomes and, collaboratively, we have explored the involvement of the microbiota in the responsiveness of melanoma patients to immunotherapy.
One or more keywords matched the following items that are connected to Alegre, Maria-Luisa
Item TypeName
Concept Mice, Inbred C3H
Concept Mice, Inbred Strains
Concept Mice, Transgenic
Concept Mice, Inbred BALB C
Concept Mice, Inbred C57BL
Concept Mice, Nude
Concept Mice, Inbred DBA
Concept Mice, Obese
Concept Mice, Knockout
Concept Mice, Congenic
Concept Mice
Concept Mice, SCID
Academic Article Tissue distribution, regulation and intracellular localization of murine CD1 molecules.
Academic Article Regulation of surface and intracellular expression of CTLA4 on mouse T cells.
Academic Article Impaired negative selection in CD28-deficient mice.
Academic Article Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody.
Academic Article Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.
Academic Article Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.
Academic Article Transplantation and the CD28/CTLA4/B7 pathway.
Academic Article Role of STAT6 signaling in the induction and long-term maintenance of tolerance mediated by CTLA4-Ig.
Academic Article Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice.
Academic Article Secondary lymphoid organs are important but not absolutely required for allograft responses.
Academic Article Impaired NF-kappaB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin grafts.
Academic Article TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism.
Academic Article GATA-3: an unexpected regulator of cell lineage determination in skin.
Academic Article Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase.
Academic Article Modulation of tryptophan catabolism by regulatory T cells.
Academic Article CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway.
Academic Article Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.
Academic Article CTLA-4 engagement regulates NF-kappaB activation in vivo.
Academic Article Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration.
Academic Article Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice.
Academic Article Transplantation tolerance in NF-kappaB-impaired mice is not due to regulation but is prevented by transgenic expression of Bcl-xL.
Academic Article Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation.
Academic Article Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.
Academic Article Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues.
Academic Article Role of natural killer cell subsets in cardiac allograft rejection.
Academic Article Costimulatory molecules as targets for the induction of transplantation tolerance.
Academic Article Overexpression of program death-1 in T cells has mild impact on allograft survival.
Academic Article Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection.
Academic Article Fas mediates cardiac allograft acceptance in mice with impaired T-cell-intrinsic NF-kappaB signaling.
Academic Article Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells.
Academic Article TLR signals promote IL-6/IL-17-dependent transplant rejection.
Academic Article T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b.
Academic Article IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice.
Academic Article High TCR stimuli prevent induced regulatory T cell differentiation in a NF-?B-dependent manner.
Academic Article TLR engagement prevents transplantation tolerance.
Academic Article An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity.
Academic Article Epidermal Langerhans cells promote skin allograft rejection in mice with NF-kappa B-impaired T cells.
Academic Article Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes.
Academic Article A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo.
Academic Article Prevention of the humoral response induced by an anti-CD3 monoclonal antibody by deoxyspergualin in a murine model.
Academic Article Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts.
Academic Article Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells.
Academic Article CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells.
Academic Article Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model.
Academic Article Role of T-cell-specific nuclear factor ?B in islet allograft rejection.
Academic Article T cell receptor/CARMA1/NF-?B signaling controls T-helper (Th) 17 differentiation.
Academic Article Expression and function of CTLA-4 in Th1 and Th2 cells.
Academic Article CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo.
Academic Article Formation of a central supramolecular activation cluster is not required for activation of naive CD8+ T cells.
Academic Article Protective immunity against recurrent Staphylococcus aureus skin infection requires antibody and interleukin-17A.
Academic Article Lessons and limits of mouse models.
Academic Article Basal NF-?B controls IL-7 responsiveness of quiescent naïve T cells.
Academic Article STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Academic Article Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage.
Academic Article T-cell regulation by CD28 and CTLA-4.
Academic Article Spontaneous restoration of transplantation tolerance after acute rejection.
Academic Article Proteomic Identification of saeRS-Dependent Targets Critical for Protective Humoral Immunity against Staphylococcus aureus Skin Infection.
Academic Article Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
Academic Article Cutting Edge: Engineering Active IKKß in T Cells Drives Tumor Rejection.
Academic Article High-Fat Diet-Induced Obesity Enhances Allograft Rejection.
Academic Article Tumor-associated fibroblasts predominantly come from local and not circulating precursors.
Academic Article The composition of the microbiota modulates allograft rejection.
Academic Article Delayed Cytotoxic T Lymphocyte-Associated Protein 4-Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute Rejection.
Academic Article Standardizing Mouse Models to Account for Host-Microbial Interactions.
Academic Article Adoptive Transfer of Tracer-Alloreactive CD4+ T Cell Receptor Transgenic T Cells Alters the Endogenous Immune Response to an Allograft.
Academic Article Long-term Maintenance of Sterility Following Skin Transplantation in Germ-free Mice.
Academic Article Erosion of Transplantation Tolerance After Infection.
Academic Article Tracking of TCR-Transgenic T Cells Reveals That Multiple Mechanisms Maintain Cardiac Transplant Tolerance in Mice.
Academic Article Evolving Approaches in the Identification of Allograft-Reactive T and B Cells in Mice and Humans.
Academic Article Successful Treatment of T Cell-Mediated Acute Rejection with Delayed CTLA4-Ig in Mice.
Academic Article The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients.
Academic Article Gut microbes contribute to variation in solid organ transplant outcomes in mice.
Academic Article T Cell Receptor-Regulated TGF-ß Type I Receptor Expression Determines T Cell Quiescence and Activation.
Academic Article Distinct Graft-Specific TCR Avidity Profiles during Acute Rejection and Tolerance.
Academic Article Gut Microbiota Can Impact Chronic Murine Lung Allograft Rejection.
Academic Article Thymic regulatory T cells arise via two distinct developmental programs.
Academic Article Exercise increases skin graft resistance to rejection.
Academic Article Mouse microbiomes: overlooked culprits of experimental variability.
Grant Impact of Microbiota on Alloimmune Responses in Transplantation
Grant Infections and the Stability of Transplantation Tolerance
Grant The microbiota and allograft rejection: novel investigations into the consequences of obesity
Academic Article Skin-restricted commensal colonization accelerates skin graft rejection.
Academic Article Resilience of T cell-intrinsic dysfunction in transplantation tolerance.
Academic Article Pathogenic Bhlhe40+ GM-CSF+ CD4+ T cells promote indirect alloantigen presentation in the GI tract during GVHD.
Academic Article Inhibition of protective immunity against Staphylococcus aureus infection by MHC-restricted immunodominance is overcome by vaccination.
Academic Article Liver Protection by ILC1s.
Academic Article Transplantation tolerance modifies donor-specific B cell fate to suppress de novo alloreactive B cells.
Academic Article Pregnancy-induced humoral sensitization overrides T cell tolerance to fetus-matched allografts in mice.
Academic Article Restored TDCA and valine levels imitate the effects of bariatric surgery.
Academic Article Taurodeoxycholic acid and valine reverse obesity-associated augmented alloimmune responses and prolong allograft survival.
Academic Article Oral alloantigen exposure promotes donor-specific tolerance in a mouse model of minor-mismatched skin transplantation.
Academic Article Linked sensitization by memory CD4+ T cells prevents costimulation blockade-induced transplantation tolerance.
Academic Article Host-versus-commensal immune responses participate in the rejection of colonized solid organ transplants.
Academic Article Reduced Satb1 expression predisposes CD4+ T conventional cells to Treg suppression and promotes transplant survival.
Academic Article Oral administration of the commensal Alistipes onderdonkii prolongs allograft survival.
Grant Role of NF-kB Activation in Acute Allograft Rejection
Grant Mechanisms of TLR-mediated prevention of transplantation tolerance
Grant Role of NF-kB Activation in Acute Allograft Rejection
Grant NF-kappaBeta activation T cell function/graft rejection
Academic Article Microbiota-dependent and -independent effects of obesity on transplant rejection and hyperglycemia.
Academic Article Sex, T Cells, and the Microbiome in Natural ABO Antibody Production in Mice.
Academic Article Heterogeneity in allospecific T cell function in transplant-tolerant hosts determines susceptibility to rejection following infection.
Academic Article Sex, T Cells, and the Microbiome in Natural ABO Antibody Production in Mice.
Academic Article Advancing mouse models for transplantation research.
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