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Search Results to Maria-Luisa Alegre

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One or more keywords matched the following properties of Alegre, Maria-Luisa

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keywords Immunology
keywords Immunology, Transplantation
overview My laboratory is interested in T cell responses in settings of transplantation, autoimmunity and cancer, with an emphasis on mouse models and emerging extensions onto clinical translation. A main focus of the laboratory is on T cell tolerance in transplantation and how infections and inflammatory events can affect induction or maintenance of tolerance. We have found that transplantation tolerance can exist at different levels of robustness based on the number of mechanisms of T cell tolerance that are engaged, and that infections or inflammation can erode such tolerance. The impact of bacterial infections on transplant outcomes has led us to discover that the microbiota also influences immune responses to transplanted organs and can be manipulated to prolong graft survival. Our clinical studies have focused on the immunology of transplant recipients and of patients infected with the bacteria that influence transplant outcomes and, collaboratively, we have explored the involvement of the microbiota in the responsiveness of melanoma patients to immunotherapy.

One or more keywords matched the following items that are connected to Alegre, Maria-Luisa

Item TypeName
Concept Blood Platelets
Concept Transplantation Immunology
Academic Article Costimulatory molecules as targets for the induction of transplantation tolerance.
Academic Article Secondary lymphoid organs are important but not absolutely required for allograft responses.
Academic Article Transplantation tolerance in NF-kappaB-impaired mice is not due to regulation but is prevented by transgenic expression of Bcl-xL.
Academic Article Cellular mechanisms underlying acute graft rejection: time for reassessment.
Academic Article The multiple facets of toll-like receptors in transplantation biology.
Academic Article Toll-like receptors (TLRs) in transplantation.
Academic Article Bacterial infections, alloimmunity, and transplantation tolerance.
Academic Article Role of T cell-nuclear factor ?B in transplantation.
Academic Article Antagonistic effect of toll-like receptor signaling and bacterial infections on transplantation tolerance.
Academic Article IFN-?: The Dr. Jekyll and Mr. Hyde of immunology?
Academic Article Lessons and limits of mouse models.
Academic Article Antigen Presentation in Transplantation.
Academic Article Resilience of T cell-intrinsic dysfunction in transplantation tolerance.
Academic Article Introduction to this Cellular Immunology issue on new advances in solid organ transplantation immunology.
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Search Criteria
  • Platelet
  • immunology